“…Lastly, improper prioritisation of RRS-activation barriers such as calling the doctor, consulting a colleague, or continuing observation, over timely RRS-activation causes prolongation of afferent limb (Wood et al, 2019), and thus, a delay in RRS-activation. Of note, any delay in RRS-activation is associated with adverse outcomes (Reardon et al, 2018), such as in-hospital cardiac arrest and cardiovascular dysfunction, unplanned ICU admissions, mortality, and hospital length of stay (Kollef et al, 2017;Lee et al, 2018;Moreira et al, 2018;Reardon et al, 2018;Tirkkonen et al, 2013;Xu et al, 2018).…”