Rapid, simple and accurate liquid chromatography–diode array detection validated method for the determination of dipyrone in solid and liquid dosage forms

Şenyuva, Hamide Z.; Akşahın, İnci; Özcan, Süreyya; Kabasakal, B.V.

doi:10.1016/j.aca.2004.12.053

Cited by 29 publications

(16 citation statements)

References 9 publications

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“…The results obtained with the proposed method were compared to those obtained by reverse‐phase liquid chromatography (HPLC) (reference method), involving an Agilent Technologies 1200 Liquid Chromatograph equipped with a diode array detector (DAD), a thermostatic column module, a quaternary pump and an Agilent Eclipse XDB‐C 18 LC column (5 µm particle size, 4.6 mm × 150 mm i.d.). The injection volume was 100 μL and the DAD wavelength 254.4 nm.…”

Section: Methodsmentioning

confidence: 99%

“…Most of the methods used for the determination of this drug are based on titrimetry , amperometry , spectrophotometry , polarography , HPLC and chemiluminescence . The spectrophotometric and chemiluminescent methods, especially when combined with flow‐injection analysis (FIA), provide economic, simple, sensitive and rapid assessment procedures, e.g.…”

Section: Introductionmentioning

confidence: 99%

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Determination of dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide–H₂O₂–vanadium(IV) system and flow‐injection analysis

et al. 2011

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A rapid, economic and sensitive chemiluminescent method involving flow-injection analysis was developed for the determination of dipyrone in pharmaceutical preparations. The method is based on the chemiluminescent reaction between quinolinic hydrazide and hydrogen peroxide in a strongly alkaline médium, in which vanadium(IV) acts as a catalyst. Principal chemical and physical variables involved in the flow-injection system were optimized using a modified simplex method. The variations in the quantum yield observed when dipyrone was present in the reaction médium were used to determine the concentration of this compound. The proposed method requires no preconcentration steps and reliably quantifies dipyrone over the linear range 1-50ug/mL. In addition, a sample throughput of 85 samples/h is possible.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide–H₂O₂–vanadium(IV) system and flow‐injection analysis

et al. 2011

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“…The drug can cause occasional or rare reactions as transitory disturbances and inflammation of the renal tissue, mainly in patients with renal disease history or in cases of overdose [27]. Flow injection amperometric, biamperometric, liquid chromatography-diode array, reflectometric and liquid chromatography/mass spectrometry methods described for the determination of dipyrone (DP) [28][29][30][31][32]. Determination of dipyrone and acetaminophen in pharmaceutical preparations by cyclic voltammetry at a copper(II) hexacyanoferrate(III)-modified carbon paste electrode were also studied by Teixeira et al [33].…”

Section: Introductionmentioning

confidence: 99%

Determination of three analgesics in pharmaceutical and urine sample on nano poly (3, 4-ethylenedioxythiophene) modified electrode

Gopalakrishnan

Muralidharan

Vedhi³

et al. 2011

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Three analgesics, acetaminophen, acetylsalicylic acid, and dipyrone were determined by stripping voltammetry using nanosized poly(3,4-ethylenedioxythiophene)-modified glassy carbon electrode . The cyclic voltammetric behavior of the three analgesics was studied in aqueous acid, neutral, and alkaline conditions. One well-defined oxidation peak each for acetaminophen and acetylsalicylic acid and three oxidation peaks for dipyrone were observed in the cyclic voltammograms. The influence of pH, scan rate, and concentration revealed irreversible diffusion controlled reaction. A systematic study of the experimental parameters that affect the differential pulse stripping voltammetric response was carried out. Calibration was made under maximum peak current conditions. The scanning electron microscope analysis confirmed good accumulation of the drugs on the electrode surface. The range of study for both acetaminophen, acetylsalicylic acid were 0.015-0.4 and dipyrone was 0.025-0.4 μg/ml. The lower limit of determination for both acetaminophen, acetylsalicylic acid was 0.01 μg/mL and for dipyrone was 0.02 μg/mL. The suitability of the method for the determination of the three analgesics in pharmaceutical preparations and urine samples was also ascertained.

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“…For dipyrone, procedures employing titration, 7,8 chromatography, 9,10 voltammetry, 11 polarography, 12 spectrophotometry, 13,14 and flow methods using many detectors [14][15][16][17][18][19][20] are described. For paracetamol, in the same manner, a considerable number of analytical methods are mentioned, as highlighted in a review recently published and other related works.…”

Section: Introductionmentioning

confidence: 99%

Simple flow injection amperometric system for simultaneous determination of dipyrone and paracetamol in pharmaceutical formulations

Santos¹,

Gimenes²,

Almeida³

et al. 2009

J. Braz. Chem. Soc.

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Este trabalho descreve uma metodologia simples empregando análise por injeção em fluxo com detecção amperométrica pulsada para determinação simultânea de dipirona (DI) e paracetamol (PCT) em formulações farmacêuticas. Os compostos são detectados através da aplicação de quatro pulsos de potencial (seqüenciais) em função do tempo. Dipirona é diretamente detectada em +0,40 V e paracetamol indiretamente em 0,00 V através da redução do produto de oxidação (N-acetil-pbenzoquinonaimina) gerada eletroquimicamente em +0,65 V. O quarto pulso de potencial (-0,05 V) é aplicado para a regeneração ou limpeza do eletrodo de trabalho (carbono vítreo). A faixa linear de resposta foi otimizada em 9 a 45 mg L -1 para dipirona e em 6 a 30 mg L -1 para paracetamol. As regressões lineares para as duas curvas analíticas apresentaram excelentes coeficientes de correlação (R = 0,999), assim como os resultados obtidos nos estudos de adição-recuperação (ca. 100%). A freqüência analítica para a metodologia proposta foi calculada em 45 injeções hora com o consumo de 1,5 mL de solução por minuto. O desvio padrão relativo do sinal para 24 injeções sucessivas foi calculado em 0,4 % para dipirona e 0,2 % para paracetamol. O método proposto foi usado com sucesso para a determinação destes compostos em formulações farmacêuticas.In this work a simple flow injection methodology with pulsed amperometric detection for simultaneous determination of dipyrone (DI) and paracetamol (PCT) in pharmaceutical formulations is described. The compounds are detected by applying four sequential potential pulses as function of the time. Dipyrone is directly detected at +0.40 V and paracetamol indirectly at 0.00 V through the reduction of the oxidation product (N-acetyl-p-benzoquinoneimine) electrochemically generated at +0.65 V. The fourth potential pulse (-0.05 V) is applied for the cleaning of the electrode surface (glassy carbon). The linear response range was optimized between 9 and 45 mg L -1 for dipyrone and 6 and 30 mg L -1 for paracetamol. Linear regression of these two series of experiments leads to excellent correlation coefficients (R = 0.999) for both analytes and recoveries of around 100%. The proposed methodology allows an analytical frequency of 45 injections h -1 with a consumption of 1.5 mL of solution per minute. The relative standard deviation for 24 successive injections of solutions containing DI and PCT was calculated as 0.4% and 0.2%, respectively. The developed methodology was successfully used for the determination of dipyrone and paracetamol in pharmaceutical samples.Keywords: simultaneous determination, dipyrone, paracetamol, flow injection analysis (FIA), multiple pulse amperometric detection IntroductionDipyrone (DI), also known as metamizol, is a widely used analgesic and antipyretic with proven efficiency in pharmaceutical formulations.1 Despite being restricted in some countries, like the United States, DI is commercially available in Brazil, mainly due to its strong analgesic effect and a relative low cost.2 In some drugs, DI is pre...

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Rapid, simple and accurate liquid chromatography–diode array detection validated method for the determination of dipyrone in solid and liquid dosage forms

Cited by 29 publications

References 9 publications

Determination of dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide–H₂O₂–vanadium(IV) system and flow‐injection analysis

Determination of dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide–H₂O₂–vanadium(IV) system and flow‐injection analysis

Determination of three analgesics in pharmaceutical and urine sample on nano poly (3, 4-ethylenedioxythiophene) modified electrode

Simple flow injection amperometric system for simultaneous determination of dipyrone and paracetamol in pharmaceutical formulations

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Rapid, simple and accurate liquid chromatography–diode array detection validated method for the determination of dipyrone in solid and liquid dosage forms

Cited by 29 publications

References 9 publications

Determination of dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide–H2O2–vanadium(IV) system and flow‐injection analysis

Determination of dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide–H2O2–vanadium(IV) system and flow‐injection analysis

Determination of three analgesics in pharmaceutical and urine sample on nano poly (3, 4-ethylenedioxythiophene) modified electrode

Simple flow injection amperometric system for simultaneous determination of dipyrone and paracetamol in pharmaceutical formulations

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Product

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Determination of dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide–H₂O₂–vanadium(IV) system and flow‐injection analysis

Determination of dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide–H₂O₂–vanadium(IV) system and flow‐injection analysis