Rapid spread of an ongoing outbreak of Zika virus disease in pregnant women in a Mexican hospital

Garza‐González, Elvira; Mendoza-Olazarán, Soraya; Roman-Campos, Raúl; Téllez-Marroquín, Ricardo; Saldívar-Rodríguez, Donato; Soria-López, Juan A; Guzmán, A Rubén Darío; Flores-Treviño, Samantha; Camacho-Ortíz, Adrián

doi:10.1016/j.bjid.2017.04.008

Cited by 9 publications

(5 citation statements)

References 8 publications

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“…Taste disturbances, pharyngitis, and other symptoms were rarely described. For ZIKV, fever, headache, chills, arthralgia, conjunctivitis, nausea, myalgia, pruritus, rash, retro-orbital pain, and abdominal pain have been previously reported by other working groups [5,6,39,40].…”

Section: Discussionmentioning

confidence: 70%

“…Arbovirus is manifested as a wide variety of clinical symptoms in the host that can range from asymptomatic or oligosymptomatic infection to even death [1,2]. During the acute phases of arboviruses such as dengue fever (DENV), chikungunya (CHIKV), and zika (ZIKV), the clinical manifestations are similar [3][4][5][6][7]. This fact complicates correct identification.…”

Section: Introductionmentioning

confidence: 99%

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Molecular Characterization of Associated Pathogens in Febrile Patients during Inter-Epidemic Periods of Urban Arboviral Diseases in Tapachula Southern Mexico

et al. 2021

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Emerging and re-emerging vector-borne infections are a global public health threat. In endemic regions, fever is the main reason for medical attention, and the etiological agent of such fever is not usually identified. In this study, non-specific febrile pathogens were molecularly characterized in serum samples from 253 patients suspected of arbovirus infection. The samples were collected in the southern border region of Mexico from April to June 2015, and February to March 2016. ZIKV, CHIKV, DENV, leptospirosis, and rickettsiosis were detected by qPCR and nested PCR to identify flavivirus and alphavirus genera. The results indicated that 71.93% of the samples were positive for CHIKV, 0.79% for ZIKV, and 0.39% for DENV, with the number positive for CHIKV increasing to 76.67% and those positive for ZIKV increasing to 15.41% under the nested PCR technique. Leptospira Kmetyi was identified for the first time in Mexico, with a prevalence of 3.16%. This is the first report of ZIKV in Mexico, as well the first detection of the virus in early 2015. In conclusion, the etiological agent of fever was determined in 94% of the analyzed samples.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Molecular Characterization of Associated Pathogens in Febrile Patients during Inter-Epidemic Periods of Urban Arboviral Diseases in Tapachula Southern Mexico

et al. 2021

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“…Nosocomial Aedes and Culex-borne arbovirus transmission is widely ignored by surveillance and vector control programs, even though healthcare-associated infections (HAI) are considered a serious threat to patient safety worldwide [35,36]. This is particularly troublesome, as pointed out by Garza-González et al (2017) [37], who reported a rapid ZIKV infection in pregnant women in a teaching hospital in Mexico. According to the WHO [38], the precise burden of HAI in low and middle-income countries remains undetermined.…”

Section: Discussionmentioning

confidence: 99%

Potential Nosocomial Infections by the Zika and Chikungunya Viruses in Public Health Facilities in the Metropolitan Area of Recife, Brazil

et al. 2022

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Since 2015, the Dengue, Zika, and Chikungunya viruses gained notoriety for their impact in public health in many parts of the globe, including Brazil. In Recife, the capital of Pernambuco State, the introduction of ZIKV impacted human population tremendously, owing to the increase in the number of neurological cases, such as the Guillain–Barré and congenital Zika disorders. Later, Recife was considered to be the epicenter for ZIKV epidemics in Brazil. For arboviral diseases, there are some risk factors, such as climate changes, low socioeconomic conditions, and the high densities of vectors populations, that favor the broad and rapid dispersion of these three viruses in the city. Therefore, continuous arbovirus surveillance provides an important tool for detecting these arboviruses and predicting new outbreaks. The purpose of the present study was to evaluate the circulation of DENV, ZIKV, and CHIKV by RT-qPCR in mosquitoes collected in health care units from the metropolitan area of Recife (MAR), during 2018. A total of 2321 female mosquitoes (357 pools) belonging to two species, Aedes aegypti and Culex quinquefasciatus, were collected from 18 different healthcare units, distributed in five cities from the MAR. Twenty-three pools were positive for ZIKV, out of which, seventeen were of C. quinquefasciatus and six were of A. aegypti. Positive pools were collected in 11/18 health care units screened, with Cq values ranging from 30.0 to 37.4 and viral loads varying from 1.88 × 107 to 2.14 × 109 RNA copies/mL. Nosocomial Aedes- and Culex-borne transmission of arbovirus are widely ignored by surveillance and vector control programs, even though healthcare-associated infections (HAI) are considered a serious threat to patient safety worldwide. Although the results presented here concern only the epidemiological scenario from 2018 in MAR, the potential of hospital-acquired transmission through mosquito bites is being overlooked by public health authorities. It is, therefore, of the ultimate importance to establish specific control programs for these locations.

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“…Symptomatic Zika infection is characterized by rash, fever, conjunctivitis, malaise, myalgia, arthralgia, edema, headache, and retro-ocular pain ( Brooks et al, 2017 ; Garza-González et al, 2017 ), which makes it difficult to differentiate clinically from dengue and chikungunya virus infections, which are both regionally endemic ( Braga et al, 2017 ; Colombo et al, 2017 ). Moreover, concurrent outbreaks and even co-infections may occur ( Braga et al, 2017 ; Mercado-Reyes et al, 2019 ), and the clinical presentation may vary geographically ( Braga et al, 2017 ; Brenciaglia et al, 2018 ; Silva et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Patterns of signs, symptoms, and laboratory values associated with Zika, dengue, and undefined acute illnesses in a dengue endemic region: Secondary analysis of a prospective cohort study in southern Mexico

Hunsberger

Ortega-Villa

Powers

et al. 2020

International Journal of Infectious Diseases

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Dengue and Zika infections cause illnesses with overlapping clinical manifestations. The aim of this study was to explore the association of each of these infections with single or grouped clinical and laboratory parameters. Methods: Clinical and laboratory data were collected prospectively from a cohort of patients seeking care for symptoms meeting the Pan American Health Organization's modified case-definition criteria for probable Zika virus infection. Zika and dengue were diagnosed with RT-PCR. The relationship of clinical characteristics and laboratory data with Zika, dengue, and undefined acute illness (UAI) was examined. Results: In the univariate models, localized rash and maculopapular exanthema were associated with Zika infection. Generalized rash, petechiae, and petechial purpuric rash were associated with dengue. Cough and confusion/disorientation were associated with UAI. Platelets were significantly lower in the dengue group. A conditional inference tree model showed poor sensitivity and positive predictive value for individual viral diagnoses. Conclusions: Clusters of signs, symptoms, and laboratory values evaluated in this study could not consistently differentiate Zika or dengue cases from UAI in the clinical setting at the individual patient level. We identified symptoms that are important to Zika and dengue in the univariate analyses, but predictive models were unreliable. Low platelet count was a distinctive feature of dengue.

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Rapid spread of an ongoing outbreak of Zika virus disease in pregnant women in a Mexican hospital

Cited by 9 publications

References 8 publications

Molecular Characterization of Associated Pathogens in Febrile Patients during Inter-Epidemic Periods of Urban Arboviral Diseases in Tapachula Southern Mexico

Molecular Characterization of Associated Pathogens in Febrile Patients during Inter-Epidemic Periods of Urban Arboviral Diseases in Tapachula Southern Mexico

Potential Nosocomial Infections by the Zika and Chikungunya Viruses in Public Health Facilities in the Metropolitan Area of Recife, Brazil

Patterns of signs, symptoms, and laboratory values associated with Zika, dengue, and undefined acute illnesses in a dengue endemic region: Secondary analysis of a prospective cohort study in southern Mexico

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