Rapid, Stability-Indicating, High-Pressure Liquid Chromatographic Determination of Theophylline, Guaifenesin, and Benzoic Acid in Liquid and Solid Pharmaceutical Dosage Forms

Heidemann, D.R.

doi:10.1002/jps.2600680443

Journal of Pharmaceutical Sciences

1979

DOI: 10.1002/jps.2600680443

|View full text |Cite

Rapid, Stability-Indicating, High-Pressure Liquid Chromatographic Determination of Theophylline, Guaifenesin, and Benzoic Acid in Liquid and Solid Pharmaceutical Dosage Forms

D.R. Heidemann¹

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1988

2014

Publication Types

Select...

Article6

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 20 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some stability-indicating assay methods (SIAM) of GFN and TBN along with other active ingredients, excipients and impurities in liquid and solid dosage forms are reported[12–15]. Different HPLC methods for individual assay and related substances are available for TBN, GFN and BHN in official pharmacopoeia[16–18].…”

mentioning

confidence: 99%

Stability-indicating HPLC method for simultaneous determination of terbutaline sulphate, bromhexine hydrochloride and guaifenesin

Porel¹,

Haty²,

Kundu³

2011

Indian J Pharm Sci

View full text Add to dashboard Cite

The aim of the present study was the development and subsequent validation of a simple, precise and stability-indicating reversed phase HPLC method for the simultaneous determination of guaifenesin, terbutaline sulphate and bromhexine hydrochloride in the presence of their potential impurities in a single run. The photolytic as well as hydrolytic impurities were detected as 3,5-dihydroxybenzoic acid, 3,5-dihydroxybenzaldehyde, 1-(3,5-dihydroxyphenyl)-2-[(1,1-dimethylethyl) amino]-ethanone from terbutaline, 2-methoxyphenol and an unknown impurity identified as (2RS)-3-(2-hydroxyphenoxy)-propane-1,2-diol from guaifenesin. The chromatographic separation of all the three active components and their impurities was achieved on Wakosil II column, using phosphate buffer (pH 3.0) and acetonitrile as mobile phase which was delivered initially in the ratio of 80:20 (v/v) for 18 min, then changed to 60:40 (v/v) for next 12 min, and finally equilibrated back to 80:20 (v/v) for 10 min. Other HPLC parameters were: Flow rate at 1.0 ml/min, detection wavelengths 248 and 280 nm, injection volume 10 μl. The calibration graphs plotted with five concentrations of each component were linear with a regression coefficient R2 >0.9999. The limit of detection and limit of quantitation were estimated for all the five impurities. The established method was then validated for linearity, precision, accuracy, and specificity and demonstrated to be applicable to the determination of the active ingredients in commercial and model cough syrup. No interference from the formulation excipients was observed. These results suggest that this LC method can be used for the determination of multiple active ingredients and their impurities in a cough and cold syrup.

show abstract

mentioning

confidence: 99%

Stability-indicating HPLC method for simultaneous determination of terbutaline sulphate, bromhexine hydrochloride and guaifenesin

Porel¹,

Haty²,

Kundu³

2011

Indian J Pharm Sci

View full text Add to dashboard Cite

show abstract

Simultaneous Voltammetric Determination of Theophylline and Guaifenesin Using a Multiwalled Carbon Nanotube‐Ionic Liquid Modified Glassy Carbon Electrode

Gholivand

Khodadadian

2014

Electroanalysis

View full text Add to dashboard Cite

show abstract

A Rapid Sample Clean-Up For Determining 5-Hydroxymethylfurfural in Dextrose: Theophylline Injection

Hryncewicz

Byrne

1988

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Rapid, Stability-Indicating, High-Pressure Liquid Chromatographic Determination of Theophylline, Guaifenesin, and Benzoic Acid in Liquid and Solid Pharmaceutical Dosage Forms

Cited by 20 publications

References 19 publications

Stability-indicating HPLC method for simultaneous determination of terbutaline sulphate, bromhexine hydrochloride and guaifenesin

Stability-indicating HPLC method for simultaneous determination of terbutaline sulphate, bromhexine hydrochloride and guaifenesin

Simultaneous Voltammetric Determination of Theophylline and Guaifenesin Using a Multiwalled Carbon Nanotube‐Ionic Liquid Modified Glassy Carbon Electrode

A Rapid Sample Clean-Up For Determining 5-Hydroxymethylfurfural in Dextrose: Theophylline Injection

Contact Info

Product

Resources

About