Rapid synthesis for monodispersed gold nanoparticles in kaempferol and anti-leishmanial efficacy against wild and drug resistant strains

Halder, Asim; Das, Suvadra; Bera, Tanmoy; Mukherjee, Arup

doi:10.1039/c6ra28632a

Cited by 44 publications

(34 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…have been successfully used in the green synthesis of NPs. Highly monodispersed (18.24 nm) spherical Au NPs could be synthesized using kaempferol as the in situ reductant and stabilizer [ 141 ]. The ability of terpenoid fractions isolated from Andrographis paniculata leaves for the green synthesis of ZnO NPs has also been demonstrated and confirmed by the presence of C=O functional group in the NPs [ 142 ].…”

Section: Secondary Metabolites In Plant Extract-mediated Green Synmentioning

confidence: 99%

Secondary Metabolites in the Green Synthesis of Metallic Nanoparticles

Marslin¹,

et al. 2018

View full text Add to dashboard Cite

The ability of organisms and organic compounds to reduce metal ions and stabilize them into nanoparticles (NPs) forms the basis of green synthesis. To date, synthesis of NPs from various metal ions using a diverse array of plant extracts has been reported. However, a clear understanding of the mechanism of green synthesis of NPs is lacking. Although most studies have neglected to analyze the green-synthesized NPs (GNPs) for the presence of compounds derived from the extract, several studies have demonstrated the conjugation of sugars, secondary metabolites, and proteins in these biogenic NPs. Despite several reports on the bioactivities (antimicrobial, antioxidant, cytotoxic, catalytic, etc.) of GNPs, only a handful of studies have compared these activities with their chemically synthesized counterparts. These comparisons have demonstrated that GNPs possess better bioactivities than NPs synthesized by other methods, which might be attributed to the presence of plant-derived compounds in these NPs. The ability of NPs to bind with organic compounds to form a stable complex has huge potential in the harvesting of precious molecules and for drug discovery, if harnessed meticulously. A thorough understanding of the mechanisms of green synthesis and high-throughput screening of stabilizing/capping agents on the physico-chemical properties of GNPs is warranted to realize the full potential of green nanotechnology.

show abstract

Section: Secondary Metabolites In Plant Extract-mediated Green Synmentioning

confidence: 99%

Secondary Metabolites in the Green Synthesis of Metallic Nanoparticles

Marslin¹,

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Gallic acid possessing three hydroxyl groups on phenyl rings can cleavage the hydrogen ion and give one electron to silver (I) to become an oxidized gallic acid, and silver (I) ions become AgNPs [34]. In the case of quercetin, kaempferol and rutin, they also have the hydroxyl groups of phenyl ring, and can act as an oxidant with a similar mechanism of gallic acid [35][36][37][38]. S. dulcis was found to contain flavonoid, alkaloid and tannin [24] which also possess the hydroxyl groups performing the role of the reductant.…”

Section: The Formation Of Biosynthesized Agnps Including Aaagnps Andmentioning

confidence: 99%

Silver Nanoparticles Ecofriendly Synthesized by Achyranthes aspera and Scoparia dulcis Leaf Broth as an Effective Fungicide

Nguyen

Ching

et al. 2020

Applied Sciences

View full text Add to dashboard Cite

This study describes an inexpensive, simple and green method to form silver nanoparticles from different leaf extracts of Achyranthes aspera and Scoparia dulcis plants. The silver nitrate is reduced by Achyranthes aspera and Scoparia dulcis leaf extracts respectively to generate two silver nanoparticle types symbolized as AA.AgNPs and SD.AgNPs. The optical absorption, size and morphology of silver nanoparticles are significantly impacted by extract types. The ultraviolet visible spectrum of AA.AgNPs shows a 433-nm peak being more broadened than that of SD.AgNPs. The Fourier infrared transform spectra of two of these silver nanoparticles revealed that their surface is modified by organic constituents from extracts, and thus they are stabilized in solution without any additional reaction. Images from transmission electron microscopy and scanning electron microscope indicate that AA.AgNPs are in clusters with the size of 8–52 nm almost possessing oval shape, while SD.AgNPs are smaller size of 5-45 nm separated well in diversified shapes (spherical, triangle, quadrilateral and hexagonal). Moreover, both AA.AgNPs and SD.AgNPs exhibit the highly antifungal effect against Aspergillus niger, Aspergillus flavus and the most strong impact on Fusarium oxysporum. For these obtained results, two new silver nanoparticles are promising fungicides for various applications of medical and agricultural fields.

show abstract

“…Halder et al, prepared monodispersed kaempferol-stabilized gold nanoparticles with particle size of 18.24 nm. The nanoparticles were effective against drug resistant organisms [ 230 ]. The resistance index for the nanoparticles was higher in resistant strains suggesting specific efficacy when compared to kaempferol.…”

Section: Parasitic Infectionsmentioning

confidence: 99%

“…The nanoparticles were effective against both wild-type and drug-resistant strains. The selectivity index for the nanoparticles was lower than for amphotericin B [ 230 ]. Ahmad reported gold nanoparticles with good anti-leishmanial activity influenced by their surface macromolecules [ 229 ].…”

Section: Parasitic Infectionsmentioning

confidence: 99%

Metal-Based Nanoparticles for the Treatment of Infectious Diseases

2017

View full text Add to dashboard Cite

Infectious diseases can be transmitted and they cause a significant burden on public health globally. They are the greatest world killers and it is estimated that they are responsible for the demise of over 17 million people annually. The impact of these diseases is greater in the developing countries. People with compromised immune systems and children are the most affected. Infectious diseases may be caused by bacteria, viruses, and protozoa. The treatment of infectious diseases is hampered by simultaneous resistance to multiple drugs, indicating that there is a serious and pressing need to develop new therapeutics that can overcome drug resistance. This review will focus on the recent reports of metal-based nanoparticles that are potential therapeutics for the treatment of infectious diseases and their biological efficacy (in vitro and in vivo).

show abstract

Rapid synthesis for monodispersed gold nanoparticles in kaempferol and anti-leishmanial efficacy against wild and drug resistant strains

Abstract: Synthesis of monodispersed gold nanoparticles using kaempferol and antileishmanial activity with high macrophage uptake capacity.

Cited by 44 publications

References 43 publications

Secondary Metabolites in the Green Synthesis of Metallic Nanoparticles

Secondary Metabolites in the Green Synthesis of Metallic Nanoparticles

Silver Nanoparticles Ecofriendly Synthesized by Achyranthes aspera and Scoparia dulcis Leaf Broth as an Effective Fungicide

Metal-Based Nanoparticles for the Treatment of Infectious Diseases

Contact Info

Product

Resources

About