Rapid-test sensitivity for novel swine-origin pandemic influenza A

Tai, Chun-Fu; Lu, Chi-Jen; Shao, Pei-Lan; Lee, Ping–Ing; Chang, Luan‐Yin; Huang, Li‐Min

doi:10.1016/j.jfma.2011.06.018

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…[12] Some investigators have reported a higher sensitivity of RIDT when compared to viral culture. Cheng et al ., [24] reported an overall sensitivity of 68% and specificity of 96% compared with viral culture, whereas Tai et al ., [25] reported a overall sensitivity of 82% and specificity of 99%. Gordon reported an agreement of 86% between the two tests.…”

Section: Discussionmentioning

confidence: 99%

Performance of rapid influenza diagnostic tests (QuickVue) for Influenza A and B Infection in India

Koul

Mir

Bhat

et al. 2015

Indian Journal of Medical Microbiology

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Background Rapid point-of-care (POC) tests provide an economical alternative for rapid diagnosis and treatment of influenza, especially in public health emergency situations. Objectives To test the performance of a rapid influenza diagnostic test, QuickVue (Quidel) as a POC test against a real-time polymerase chain reaction (RT-PCR) assay for detection of influenza A and B in a developing country setting. Study Design In a prospective observational design, 600 patients with influenza-like illness (ILI) or with severe acute respiratory illness (SARI) who were referred to the Influenza Clinic of a tertiary care hospital in Srinagar, India from September 2012 to April 2013, were enrolled for diagnostic testing for influenza using QuickVue or RT-PCR. All influenza A-positive patients by RT-PCR were further subtyped using primers and probes for A/H1pdm09 and A/H3. Results Of the 600 patients, 186 tested positive for influenza A or B by RT-PCR (90 A/H1N1pdm09, 7 A/H3 and 89 influenza B), whereas only 43 tested positive for influenza (influenza A = 22 and influenza B = 21) by QuickVue. Thus, the sensitivity of the QuickVue was only 23% (95% confidence interval, CI: 17.3-29.8) and specificity was 100% (95% CI: 99.1-100) with a positive predictive value (PPV) of 100% (95% CI 91.8-100) and a negative predictive value (NPV) of 74.3% (95% CI: 70.5-77.9) as compared to RT-PCR. Conclusions The high specificity of QuickVue suggest that this POC test can be a useful tool for patient management or triaging during a public health crisis but a low sensitivity suggests that a negative test result need to be further tested using RT-PCR.

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Section: Discussionmentioning

confidence: 99%

Performance of rapid influenza diagnostic tests (QuickVue) for Influenza A and B Infection in India

Koul

Mir

Bhat

et al. 2015

Indian Journal of Medical Microbiology

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“…14 Çocuk hastalarda yapılan bir çalışmada da 970 influenza benzeri semptomları olan hastadan influenza hızlı antijen testi ve PCR ile eşzamanlı alınmış ve semptomların ilk 48 saatinde influenza hızlı antijen testinin sensitivitesi yüksek bulunmuştur. 15 Bu çalışmanın kısıtlılıkları tüm influenza antijen testi bakılan hastalarda solunum yolu viral panel PCR ile doğrulanma olmamasıdır. Ancak, PCR geç çıkması ve nispeten pahalı olması nedeniyle her hastaya uygulanamamıştır.…”

Section: Discussionunclassified

Clinical Usage of Influenza Rapid Test During Influenza Season

Arıkan¹

2021

FORBES

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Objective: Influenza A and B are important viral pathogens causing respiratory infection epidemics potentially with high morbidity and mortality.Herein we aimed to investigate clinical usage of influenza rapid test in clinical practice. Method: Children tested for nasopharyngeal influenza rapid test between September 2018- February 2019 were included in this study.Influenza rapid test was applied to pediatric patients patients admitted to paediatric infectious disease policlinic regardless of their vaccination status, and results were achieved in 10 minutes. Results: Of 265 (56.5%) male, totally 469 children, with a median age of 51 months ( 23 days-202 months) were included in this study. From 469 samples tested from patients with symptoms of repiratory tract infections, 107 (22.8%) was positive for influenza A, 20 (4.3%) was positive for influenza B, 342 was negative. Totally 127 patients, 64 (50.4%) male with a median age of 53 months ( 23 days-202 months) were tested positive for influenza. Underlying chronic disease was detected in 21 (16.5%) of patients. Fever lasting for more than 5 days was statistically significantly more common in influenza B (63.2%) positive patients compared to influenza A (15.2%) positive patients (p<0.001). Conclusions: Influenza rapid test is recommended to be used in clinical practice during influenza season, in COVID pandemic also, due to shorter duration of results,being pratical, and cost –effective.

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