Rapidly separating microneedles for transdermal drug delivery

Zhu, Dan; Wang, Qi Lei; Liu, Xubo; Guo, Xin Dong

doi:10.1016/j.actbio.2016.06.005

Cited by 103 publications

(49 citation statements)

References 39 publications

(37 reference statements)

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“…Differing from the above biodegradable MNs that permit sustained drug release, dissolving MNs offer a burst release profile. The representative polymers are hyaluronic acid (HA),8a,40 carboxymethlycellulose (CMC),8b,41 polyacrylic acid (PAA),8d PVA, PVP, sucrose, starch, trehalose,41a DNA, and their mixtures 41a,46. McCrudden and co‐workers designed a dissolving MN patch for the transdermal delivery of painkiller, ibuprofen by screening a range of food and drug administration (FDA) regulated polymers and their combinations to maximize the drug loading and mechanical properties.…”

Section: Polymeric Microneedlesmentioning

confidence: 99%

“…McCrudden and co‐workers designed a dissolving MN patch for the transdermal delivery of painkiller, ibuprofen by screening a range of food and drug administration (FDA) regulated polymers and their combinations to maximize the drug loading and mechanical properties. Poly(methyl vinyl ether/maleic acid) (PMVE/MA) was identified as the most suitable candidate 46d. Dissolution of the needles was evident in 30 s and was completed in 5 min.…”

Section: Polymeric Microneedlesmentioning

confidence: 99%

“…The problem for molding method is the poor replicability. Drawing lithography technologies including DAB and CL are thus invented to improve the replicability 46c,88. The only issue of this technology is it requires polymers that can form highly viscous solution.…”

Section: Perspectives and Future Directionsmentioning

confidence: 99%

See 2 more Smart Citations

Advances in the Formulations of Microneedles for Manifold Biomedical Applications

Chang

Zheng

Chew

et al. 2020

Adv Materials Technologies

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These MN platforms have been intensively explored for transdermal drug delivery in the treatment of both local and systemic diseases. [1c,12] They function as carriers for small molecular drugs, [13] peptides and proteins (e.g., insulin, vaccines, and antibodies), [8a,14] oligonucleotides, [11d] and nanomedicines [10a,b] and deliver them into peripheral tissues like skin, eyes, mouth, vascular wall, vagina etc. [15] Recently, MNs also receive attention from medical diagnosis and health monitoring, as they can easily access skin interstitial fluid (ISF) that is formed by blood transcapillary filtration and contains numerous biomarkers of clinical interest. [16] They can either directly sample ISF for postanalysis, [9e,11b,17] or integrate with sensing components for in situ real-time monitoring. [18] This article summarizes the recent advances in the MN field including the design, fabrication, and biomedical applications (Figure 1). The challenges and future perspectives are also discussed.

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Section: Polymeric Microneedlesmentioning

confidence: 99%

Section: Polymeric Microneedlesmentioning

confidence: 99%

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Advances in the Formulations of Microneedles for Manifold Biomedical Applications

Chang

Zheng

Chew

et al. 2020

Adv Materials Technologies

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“…Meanwhile, the mechanical strength of the bubble DMN is compromised as the stress concentration may be induced around the bubble and then initiate cracks, leading to needle fracture during application . As for the pedestal DMNs with insoluble supporting shaft, the rigid shaft serves as mechanically strong spacer to counteract skin indentation . Whereas, this approach typically involves complicated alignment and hand assembly of individual needles with millimeter dimensions, which is a poorly controlled and nonscalable process.…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Rapidly Separating Dissolving Microneedles for Precise Drug Delivery by Balancing the Mechanical Performance and Disintegration Rate

Hou

Quan

Yang

et al. 2019

Adv Healthcare Materials

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The precise delivery of traditional dissolving microneedles (TDMNs) is often limited by the incomplete insertion due to the skin deformation, and the topical irritation is inevitable after long application, which ultimately results in compromised therapeutic efficacy. The aim of this study is to develop a rapidly separating dissolving microneedles (RSDMNs) system to achieve precise drug delivery. Therapeutic molecules are concentrated in the needle tip, while the blank separating part allows it to counteract skin indentation and rapidly separate from the base part. For rational design of an ideal separating part, and the molecular interactions between polymer and sugar are explored to make a good balance between mechanical performance and disintegration rate. The optimal RSDMNs can rapidly disintegrate in the mimic skin within 30 s, and the generated micropores in the skin reseal quickly. The ex vivo drug permeation of RSDMNs is significantly higher than that of TDMNs due to the complete needle imbed aided by the separating part. Furthermore, RSDMNs exhibit excellent in vivo anti‐inflammation effect by remarkably down regulating the expression of TNF‐α, IL‐1β, and IL‐6. In conclusion, the RSDMNs can reach precise drug delivery in a short time, which are more reliable for the self‐administration strategy in the future.

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“…Several techniques are available for enhancing drug absorption through the skin. These include iontophoresis [12], sonophoresis [13], chemical penetration enhancers [14] and microneedles [15]. …”

Section: Introductionmentioning

confidence: 99%

The Influence of Solid Microneedles on the Transdermal Delivery of Selected Antiepileptic Drugs

et al. 2016

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The aim of this project was to examine the effect of microneedle rollers on the percutaneous penetration of tiagabine hydrochloride and carbamazepine across porcine skin in vitro. Liquid chromatography-mass spectrometric analysis was carried out using an Agilent 1200 Series HPLC system coupled to an Agilent G1969A TOF-MS system. Transdermal flux values of the drugs were determined from the steady-state portion of the cumulative amount versus time curves. Following twelve hours of microneedle roller application, there was a 6.74-fold increase in the percutaneous penetration of tiagabine hydrochloride (86.42 ± 25.66 µg/cm2/h) compared to passive delivery (12.83 ± 6.30 µg/cm2/h). For carbamazepine in 20% ethanol, passive transdermal flux of 7.85 ± 0.60 µg/cm2/h was observed compared to 10.85 ± 0.11 µg/cm2/h after microneedle treatment. Carbamazepine reconstituted in 30% ethanol resulted in only a 1.19-fold increase in drug permeation across porcine skin (36.73 ± 1.83 µg/cm2/h versus 30.74 ± 1.32 µg/cm2/h). Differences in flux values of untreated and microneedle-treated porcine skin using solid microneedles for the transdermal delivery of tiagabine were statistically significant. Although there were 1.38- and 1.19-fold increases in transdermal flux values of carbamazepine when applied as 20% and 30% ethanol solutions across microneedle-treated porcine skin, respectively, the increases were not statistically significant.

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Rapidly separating microneedles for transdermal drug delivery

Cited by 103 publications

References 39 publications

Advances in the Formulations of Microneedles for Manifold Biomedical Applications

Advances in the Formulations of Microneedles for Manifold Biomedical Applications

Rational Design of Rapidly Separating Dissolving Microneedles for Precise Drug Delivery by Balancing the Mechanical Performance and Disintegration Rate

The Influence of Solid Microneedles on the Transdermal Delivery of Selected Antiepileptic Drugs

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