RAR-Beta Expression Is Associated with Early Volumetric Changes to Radiation Therapy in Cervical Cancer

Kim, Woo Young; Lee, Jeong‐Won; Park, Young-Ae; Choi, Jung-Joo; Sung, Chang Ohk; Song, Sang Yong; Choi, Chel Hun; Kim, Tae-Joong; Huh, Seung Jae; Kim, Byoung-Gie; Bae, Duk-Soo

doi:10.1159/000320719

Cited by 3 publications

(2 citation statements)

References 47 publications

(32 reference statements)

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“…16 Decrease of both gene and protein expression are correlated with late response to radiotherapy in cervical cancer. 36 Checkpoint with forkhead and ring finger domains (CHFR) has recently been identified as a checkpoint protein, which safeguards mitotic entry and, therefore, affects cell cycle progression. 37 CHFR silencing leads to upregulation of PARP1, a DNA repair enzyme associated with resistance to radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Promoter hypermethylation using 24-gene array in early head and neck cancer

et al. 2014

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Silencing of tumor suppressor genes (TSGs) by DNA promoter hypermethylation is an early event in carcinogenesis and a potential target for personalized cancer treatment. In head and neck cancer, little is known about the role of promoter hypermethylation in survival. Using methylation specific multiplex ligation-dependent probe amplification (MS-MLPA) we investigated the role of promoter hypermethylation of 24 well-described genes (some of which are classic TSGs), which are frequently methylated in different cancer types, in 166 HPV-negative early oral squamous cell carcinomas (OSCC), and 51 HPV-negative early oropharyngeal squamous cell carcinomas (OPSCC) in relation to clinicopathological features and survival. Early OSCC showed frequent promoter hypermethylation in RARB (31% of cases), CHFR (20%), CDH13 (13%), DAPK1 (12%), and APC (10%). More hypermethylation (≥ 2 genes) independently correlated with improved disease specific survival (hazard ratio 0.17, P = 0.014) in early OSCC and could therefore be used as prognostic biomarker. Early OPSCCs showed more hypermethylation of CDH13 (58%), TP73 (14%), and total hypermethylated genes. Hypermethylation of two or more genes has a significantly different effect on survival in OPSCC compared with OSCC, with a trend toward worse instead of better survival. This could have a biological explanation, which deserves further investigation and could possibly lead to more stratified treatment in the future.

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Section: Discussionmentioning

confidence: 99%

Promoter hypermethylation using 24-gene array in early head and neck cancer

et al. 2014

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“…The arachidonic acid metabolism was the key pathway, which was correlated with 15 reporter metabolites [67]. Kim et al performed microarray analysis of mRNA expression and found that 53 genes were differentially expressed in an early response to radiotherapy group compared with a late response group [68]. Among 53 deregulated genes, RAR-β expression is correlated to early volumetric changes to radiation therapy in cervical cancer [68].…”

Section: Systems Biology Approaches In Cervical Cancermentioning

confidence: 99%

Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies

Lin

Zhou

et al. 2019

Computational and Structural Biotechnology Journal

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Cervical cancer is one of the common malignancies in women worldwide. Exploration of pathogenesis and molecular mechanism of cervical cancer is pivotal for development of effective treatment for this disease. Recently, systems biology approaches based on high-throughput technologies have been carried out to investigate the expression of some genes and proteins in genomics, transcriptomics, proteomics, and metabonomics of cervical cancer. Compared with traditional methods，systems biology technology has been shown to provide large of information regarding prognostic biomarkers and therapeutic targets for cervical cancer. These molecular signatures from system biology technology could be useful to understand the molecular mechanisms of cervical cancer development and progression, and help physicians to design targeted therapeutic strategies for patients with cervical cancer.

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Overexpression of the immediate early response 5 gene increases the radiosensitivity of HeLa cells

et al. 2019

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The effects of the immediate early response 5 ( IER5 ) gene on the sensitivity of HeLa cells to radiation remain unclear. In the present study, stably transfected HeLa cells resulting in the knockdown or overexpression of IER5 were investigated. In addition, xenografts of normal, IER5 -silenced and -overexpressed HeLa cells were injected into nude mice and examined. The results demonstrated that the radiosensitivity of the IER5 -overexpressed HeLa cells was significantly increased compared with that of the normal and IER5 -silenced cells. The upregulation of IER5 effectively decreased cell proliferation and IER5 silencing promoted cell proliferation compared with that in the normal HeLa cells. Following irradiation of the cells with IER5 knockdown, cell cycle was arrested at the G 2 /M phase and an increase in the proportion of S phase cells was observed. By contrast, the overexpression of IER 5 led to an increase in the proportion of G 1 phase cells. Furthermore, the upregulation of IER5 inhibited tumor growth in vivo . The present findings demonstrate that the IER5 gene affects the radiosensitivity of HeLa cells and serves an important role in cell proliferation, suggesting that this gene may be a potential radiotherapeutic target in cervical cancer.

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RAR-Beta Expression Is Associated with Early Volumetric Changes to Radiation Therapy in Cervical Cancer

Cited by 3 publications

References 47 publications

Promoter hypermethylation using 24-gene array in early head and neck cancer

Promoter hypermethylation using 24-gene array in early head and neck cancer

Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies

Overexpression of the immediate early response 5 gene increases the radiosensitivity of HeLa cells

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