Rare breast neoplasms: is there any peculiar feature on magnetic resonance mammography?

Linda, Anna; Londero, Viviana; Mazzarella, F.; Zuiani, Chiara; Bazzocchi, Massimo

doi:10.1007/s11547-007-0184-y

Cited by 10 publications

(4 citation statements)

References 42 publications

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“…Meanwhile, persistent or washout type of TIC appeared in delayed contrast phases of all four cases. All SPCs features observed from DCE-MRI are in line with findings in other papillary tumors [ 4 – 7 , 12 , 13 ].…”

Section: Discussionsupporting

confidence: 86%

A pilot evaluation of magnetic resonance imaging characteristics seen with solid papillary carcinomas of the breast in 4 patients

et al. 2017

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BackgroundSolid papillary carcinoma (SPC) is a rare variant of breast papillary carcinoma with unique pathological morphology and biological behavior. There is only one case report on T1-MRI of SPC. In this study, we report our findings on this new category of papillary carcinoma to fill the gap in MRI characterization of SPC.MethodsThis retrospective study included four pathology-confirmed in situ SPC patients. Conventional MRI, diffusion weighted imaging (DWI), and magnetic resonance spectroscopy (MRS) were performed with a 1.5 T whole-body MR scanner before surgical operation. The following characteristics of each lesion were recorded: signal intensity on T2WI/STIR and T1FSPGR, morphology, maximum lesion size, and time intensity curve (TIC) on dynamic contrast enhancement MRI (DCE-MRI), apparent diffusion coefficient (ADC) value from DWI, and Cho peak from MRS.ResultsSignal intensities of all lesions were heterogenous on T2WI/STIR and T1FSPGR. Mass enhancements were observed for all lesions with either oval or irregular shapes on DCE-MRI. The maximum lesion size ranged from 0.8 cm to 3.2 cm. All lesion margins were circumscribed, and internal enhancements were homogeneous or heterogeneous from DCE-MRI. TIC appeared with a rapid increase in initial contrast phases of all lesions. All lesions on DWI (b = 1000s/mm2) were slightly hyperintense with an ADC value range of 1.3 × 10−3 mm2/s to 1.9 × 10−3 mm2/s. Cho peak was absent at 3.2 ppm for all lesions.ConclusionsMRI characteristics of SPC include heterogeneous signal intensity within the lesion on T2WI/STIR and T1FSPGR, mass enhancement with circumscribed margins, either oval or irregular shapes, and a rapid initial enhancement of TIC on DCE-MRI. ADC values and the absence of Cho peak may provide valuable information to distinguish SPC from other invasive breast carcinomas.

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Section: Discussionsupporting

confidence: 86%

A pilot evaluation of magnetic resonance imaging characteristics seen with solid papillary carcinomas of the breast in 4 patients

et al. 2017

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“…A study of magnetic resonance mammography data from 468 patients included 27 (5.7%) cases of rare breast neoplasms, with 5 (1.0%) cases of invasive papillary neoplasms. [30] In general, distinguishing morphologic and kinetic features of rare breast neoplasms were infrequently elicited on magnetic resonance mammography. Rare breast lesions were largely characterized as benign.…”

Section: Diagnosismentioning

confidence: 99%

Papillary carcinoma of the breast: an overview

Pal

Lau

Kruper

et al. 2010

Breast Cancer Res Treat

116

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Papillary carcinoma of the breast represents approximately 0.5% of all newly diagnosed cases of breast cancer. The prevalence of both invasive and in situ papillary carcinoma seems to be greater older postmenopausal women, and -in relative terms-in males. Histologic features of the tumor include cellular proliferations surrounding fibrovascular cores, with or without invasion. In this review, characteristics of both in situ and invasive disease are outlined. Immunohistochemical analyses of papillary carcinoma suggest the utility of markers such as smooth muscle myosin heavy chain, calponin, p63 and high molecular weight keratins, which can characterize the myoepithelial cell layer. With respect to radiographic evaluation of papillary carcinoma, ultrasonography is the most extensively studied imaging modality, though magnetic resonance mammography has potential utility. Available data suggest improved outcome for papillary carcinoma as compared to invasive ductal carcinoma. Treatment-related information for patients with papillary carcinoma is limited, and patterns noted in available series suggest a variable approach to this disease. The scarcity of information underscores the need for further treatment- and outcome-related studies in papillary carcinoma of the breast.

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“…MC commonly manifests as wellcircumscribed masses. Magnetic resonance mammography appearance is nonspecific and often indicative of a benign lesion [35,36].…”

Section: Good Prognosis Er Negativementioning

confidence: 99%

Breast carcinoma—rare types: review of the literature

Yerushalmi¹,

Hayes

Gelmon³

2009

Annals of Oncology

125

100

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Invasive breast cancer is a heterogeneous disease in its presentation, pathological classification and clinical course. However, there are more than a dozen variants which are less common but still very well defined by the World Health Organization (WHO) classification. The rarity of many of these neoplasms does not allow large or randomized studies to define the optimal treatment. Many of the descriptions of these cancers are from case reports and small series. Our review brings updated information on 16 epithelial subtypes as classified by the WHO system with a very concise histopathology description and parameters helpful in the clinic. The aim of our review is to provide a tool for breast cancer caregivers which will enable a better understanding of the disease and its optimal approach to therapy. This may also stand as a clinical framework for a future understanding of these rarer breast cancers when gene analysis work is reported.

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Rare breast neoplasms: is there any peculiar feature on magnetic resonance mammography?

Abstract: Frequently, rare breast neoplasms show low suspicious morphologic and kinetic patterns at MRM, and they are often classified as indeterminate lesions. This is probably due to their high grade of differentiation and their histological features.

Cited by 10 publications

References 42 publications

A pilot evaluation of magnetic resonance imaging characteristics seen with solid papillary carcinomas of the breast in 4 patients

A pilot evaluation of magnetic resonance imaging characteristics seen with solid papillary carcinomas of the breast in 4 patients

Papillary carcinoma of the breast: an overview

Breast carcinoma—rare types: review of the literature

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