Rare earth-doped nanocrystals for bioimaging in the near-infrared region

Meng, Jiajia; Cui, Yanyan; Wang, Yaling

doi:10.1039/d2tb01731h

Cited by 12 publications

(11 citation statements)

References 158 publications

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“…Mounting evidences have proved that gold nanoparticles with a high X-ray attenuation coefficient could be employed as a CT contrast agent for tumor imaging. − In view of this, we speculated that T-CDs@Au/ALA with Au doping also had the potential for CT imaging. PBS solution was used as a control for CT imaging.…”

Section: Resultsmentioning

confidence: 97%

Mitochondrial-Targeted Gold-Doped Porous Carbon Nanodots for Combined Photothermal and Photodynamic Therapy of Breast Cancer

Zhang

Yang

et al. 2023

ACS Appl. Nano Mater.

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Mitochondrial homeostasis has been proved to be a potential oncology therapeutic target, but there is still a huge technical challenge in developing an effective therapeutic regimen in clinic. Here, we developed triphenylphosphonium conjugated gold-doped porous carbon dots with 5-aminolevulinic acid (ALA) loading (T-CDs@Au/ALA nanodots) for mitochondrial-targeting combined therapy of breast cancer. Gold doping not only significantly enhanced the photothermal effect of T-CDs@Au/ ALA nanodots but also enabled ALA (photosensitizer prodrug) loading via coordination interaction. Upon cellular internalization, the resultant T-CDs@Au/ALA nanodots were selectively enriched in the mitochondria and depleted glutathione, thus amplifying the reactive oxygen species damage caused by the accumulation of ALA-derived PpIX. Moreover, T-CDs@Au/ALA nanodots caused hyperthermia to further disrupt mitochondrial homeostasis for inducing the necrosis and apoptosis of tumor cells. Our study revealed that T-CDs@Au/ALA nanodots could use as an innovative mitochondrial homeostasis destroyer for synergistic phototherapy of breast cancer.

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Section: Resultsmentioning

confidence: 97%

Mitochondrial-Targeted Gold-Doped Porous Carbon Nanodots for Combined Photothermal and Photodynamic Therapy of Breast Cancer

Zhang

Yang

et al. 2023

ACS Appl. Nano Mater.

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“…41 Rare earth nanoprobes generally exhibit anti-Stokes properties and exhibit relatively hypochromatic-shift fluorescence under suitable light irradiation, thus being called up-conversion nanoparticles (UCNPs). 42 UCNPs are less disturbed by light scattering and background signals of biological tissues, and are ideal imageological materials for deep-tissue imaging. 43 In 2014, Ni et al constructed Gd-doped and Angiopep-2 (ANG, TFFYGGSRGKRNNFKTEEY) decorated UCNPs (ANG/PEG-UCNPs) for MR/NIR dual-modal diagnosis of GBM.…”

Section: Rare Earth Nanoprobesmentioning

confidence: 99%

“…Rare earth nanomaterials are typical multichannel luminescent materials, which emit narrow fluorescence under NIR excitation 41 . Rare earth nanoprobes generally exhibit anti‐Stokes properties and exhibit relatively hypochromatic‐shift fluorescence under suitable light irradiation, thus being called up‐conversion nanoparticles (UCNPs) 42 . UCNPs are less disturbed by light scattering and background signals of biological tissues, and are ideal imageological materials for deep‐tissue imaging 43 …”

Section: Image‐guided Diagnosis Of Gbmmentioning

confidence: 99%

Image‐guided diagnosis and treatment of glioblastoma

Bian

Wang

Chen

et al. 2023

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Self Cite

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Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis and high recurrence rate. The presence of the blood–brain barrier (BBB) prevents diagnostic and therapeutic drugs from penetrating and working in GBM. In traditional surgical treatment, it is difficult to completely distinguish the boundary between tumor and surrounding normal tissue, resulting in incomplete resection of tumor. Therefore, the diagnosis and treatment of GBM are very challenging. Several molecular probes and nanoprobes have been reported to successfully penetrate the BBB, selectively target and accumulate in GBM to achieve in situ imaging of brain tumors, thus achieving accurate diagnosis and treatment of orthotopic or non‐orthotopic GBM. This paper reviews the advances of molecular probes and nanoprobes in image‐guided diagnosis and treatment of GBM. The design principle, application, and advantages of each probe are enumerated in detail. Finally, the prospects and potential challenges of probes in the diagnosis and treatment of GBM are discussed with a view to further promote the study and application of novel imaging probes in GBM.

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“…Inflammation, being an innate response of the human immune system, assumes a pivotal role in tissue damage, bacterial infections, trauma, and various physiological processes. − However, when inflammation persists or escalates beyond normal levels, it can contribute to the onset of chronic ailments and other pathological manifestations, such as tumor, hepatitis, nephritis, cardiovascular disease, and delayed wound healing. ,− Fluorescence imaging technology assumes a critical position in the evaluation and localization of inflammation, furnishing invaluable insights for the diagnosis and management of inflammation-related disorders. The main categories of inflammation include chronic inflammation and acute inflammation.…”

Section: Fluorescence Imagingmentioning

confidence: 99%

Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region

Yang,

Jiang,

Zhang

2023

Chem. Rev.

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In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. In particular, luminescence imaging in the tissuetransparent near-infrared (NIR, 700−1700 nm) region offers tremendous potential for visualizing biological architectures and pathophysiological events in living subjects with deep tissue penetration and high imaging contrast owing to the reduced light−tissue interactions of absorption, scattering, and autofluorescence. The distinctive quantum effects of nanocrystals have been harnessed to achieve exceptional photophysical properties, establishing them as a promising category of luminescent probes. In this comprehensive review, the interactions between light and biological tissues, as well as the advantages of NIR light for in vivo luminescence imaging, are initially elaborated. Subsequently, we focus on achieving deep tissue penetration and improved imaging contrast by optimizing the performance of nanocrystal fluorophores. The ingenious design strategies of NIR nanocrystal probes are discussed, along with their respective biomedical applications in versatile in vivo luminescence imaging modalities. Finally, thought-provoking reflections on the challenges and prospects for future clinical translation of nanocrystal-based in vivo luminescence imaging in the NIR region are wisely provided.

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Rare earth-doped nanocrystals for bioimaging in the near-infrared region

Abstract: Rare earth-doped nanocrystals are widely used in medical diagnostics and bioimaging due to their narrow luminescence emission spectra (10-20 nm), long lifetime, and no photobleaching properties. Especially in the near-infrared...

Cited by 12 publications

References 158 publications

Mitochondrial-Targeted Gold-Doped Porous Carbon Nanodots for Combined Photothermal and Photodynamic Therapy of Breast Cancer

Mitochondrial-Targeted Gold-Doped Porous Carbon Nanodots for Combined Photothermal and Photodynamic Therapy of Breast Cancer

Image‐guided diagnosis and treatment of glioblastoma

Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region

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