Rare primary bladder mucosa-associated lymphoid tissue lymphoma: A case report and review of literature

Abstract

Primary bladder mucosa-associated lymphoid tissue (MALT) lymphoma is an extremely rare bladder tumor. Only scarce reports have been reported. We hereby report a case of an 81-year-old female patient with bladder tumor presenting with frequent urination and dysuria, whose pelvic magnetic resonance imaging (MRI) considered bladder cancer. She underwent transurethral resection of the bladder tumor (TURBT), and histopathology confirmed the mass to be bladder MALT lymphoma. The patient refused further treatment, and no disease recurrence one year after surgery. The current data are insufficient to draw conclusions about the long-term efficacy of treatment for this tumor, regular follow-up is necessary. To further understand the clinical features, pathology, treatment and prognosis of this tumor, we have searched the literature from 1990 to the present, analyzing a total of 64 cases of primary MALT lymphoma.

Papillary renal neoplasm with reverse polarity is biologically and clinically distinct from eosinophilic papillary renal cell carcinoma

“…Al‐Obaidy et al further characterized examples of this entity in multiple studies and labeled it as PRNRP, 2 which is the currently adopted nomenclature for this entity. To date, more than 100 PRNRP cases have been reported, and to the best of our knowledge, there are no known cases with documented disease progression or metastasis 2–4,13–18 . Similar to the previous reports, we have also found that PRNRPs had significantly smaller tumor size, lower WHO/ISUP grade, and lower stage than ePRCCs.…”

“…The evidence gathered to date indicates that PRNRP has an indolent clinical course. Most of the reported cases are pT1a stage and often they are smaller in size, below the papillary adenoma size cutoff of 1.5 cm 3,4 . To our knowledge, there are no reported cases of disease progression, documented as recurrence or metastasis 2,3 .…”

“…In the recent WHO 2022 classification, papillary renal neoplasm with reverse polarity (PRNRP) has been recognized as one of the histological patterns of papillary renal cell carcinoma (PRCC) 1 . It comprises about 4% of PRCC, it has a specific low‐grade oncocytic morphology with a linear reverse arrangement of the nuclei, and it has a characteristic immunohistochemical (IHC) profile with GATA3 positivity and weak vimentin and racemase staining 1–3 . PRNRP also commonly harbors specific KRAS mutations in exon 2, codon 12 4 …”

“…Most of the reported cases are pT1a stage and often they are smaller in size, below the papillary adenoma size cutoff of 1.5 cm 3,4 . To our knowledge, there are no reported cases of disease progression, documented as recurrence or metastasis 2,3 . On the other hand, PRCCs with eosinophilic morphology were historically grouped within the high‐grade PRCC category, as part of the traditional PRCC type 2 1 .…”

Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma of the Urinary Bladder: A Case Report of a Rare Presentation

“…The International Lymphoma Radiation Oncology Group (ILROG) suggests for indolent extranodal lymphomas a dose range of 20-30 Gy [15]. In the literature, the dose received by primary bladder MALT lymphoma ranged from 24 to 36 Gy [4,[10][11][12][13].…”