2021
DOI: 10.3389/fphys.2021.624675
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Rarely Recognized Antibody Diversification in Covid-19 Evolution to Counteract Advanced SARS-CoV-2 Evasion Strategies, and Implications for Prophylactic Treatment

Abstract: The ongoing Covid-19 pandemic underscores the importance of finding effective and safe ways to combat the virus, and to optimally understand the immune response elicited upon natural infection. This likely involves all components of the immune system, both innate and adaptive. The impetus for the rapid development of prophylactic treatment options has led to an intense focus on neutralizing antibodies (Abs), and many novel and specialized platforms have been designed to achieve that goal. B-cell immunity relie… Show more

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Cited by 4 publications
(1 citation statement)
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References 80 publications
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“…Interestingly, even a peptide derived from the Tyr-sulfated CDRH3 of E51 antibody is sufficient to engage with virus spike protein and neutralize virus isolates ( 94 , 95 ). Recently Siguna Mueller wrote an article on rarely-recognized antibody diversification against SARS-CoV and SAR-CoV-2 with a potential role of sulfated antibodies ( 96 ), as the basic residue stretches on the surface of the viral spike protein ( 97 ) can be targeted by the negatively-charged Tyr-sulfate. More novel examples in protein engineering with sTyr are expected to appear in the literatures.…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, even a peptide derived from the Tyr-sulfated CDRH3 of E51 antibody is sufficient to engage with virus spike protein and neutralize virus isolates ( 94 , 95 ). Recently Siguna Mueller wrote an article on rarely-recognized antibody diversification against SARS-CoV and SAR-CoV-2 with a potential role of sulfated antibodies ( 96 ), as the basic residue stretches on the surface of the viral spike protein ( 97 ) can be targeted by the negatively-charged Tyr-sulfate. More novel examples in protein engineering with sTyr are expected to appear in the literatures.…”
Section: Introductionmentioning
confidence: 99%