“…An increasing body of evidence indicates a potential effect of immunosuppressive therapy in RE, including high-dose corticosteroids, intravenous immunoglobulin (IVIG), and plasmapheresis, but also immunomodulatory agents like tacrolimus, and azathioprine, rituximab, and natalizumab [4] , [7] , [8] , [9] . However, it is unclear if immunotherapy can modify the long-term outcome like cognitive decline and neurological deterioration [5] , [10] . Generally, knowledge is sparse regarding the most appropriate choice and timing of anti-inflammatory therapy.…”