RASSF6-TRIM16 axis promotes cell proliferation, migration and invasion in esophageal squamous cell carcinoma

Zheng, Leilei; Zhao, Zitong; Rong, Lulu; Xue, Liyan; Song, Yongmei

doi:10.1016/j.jgg.2019.10.004

Cited by 14 publications

(9 citation statements)

References 34 publications

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“…Previous studies have con rmed that the Ras signaling pathway plays a vital role in the metabolism, growth, and differentiation of somatic cells [29,30]. As a major component of the cell membrane, the Ras family function may be realized by mediating crosstalk with other pathways, and nally regulate cell proliferation, differentiation, migration, and apoptosis [29,31]. During the development of crustaceans, they undergo a series of moltings, with every molting, the body gets longer and heavier [32].…”

Section: Discussionmentioning

confidence: 99%

Screening and analyzing of Genes and Signaling Pathways Associated with Size differentiation of Adult Male Prawn Macrobrachium nipponense

Zhu

Xue

et al. 2022

Preprint

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Adult male prawn Macrobrachium nipponense exhibits heterogeneous individual growth (HIG), they could polarize into large size males and small size males which have sizes smaller than females. Therefore, obtaining the large size prawns will increase the profit of farming. To better understand this size differentiation mechanism, we performed transcriptome sequencing from the second pereiopod, hepatopancreas, and muscle of adult male prawn M. nipponense with significant differences in size (large: 1.47±0.12g; small: 0.28±0.04g). We identified 46,557 unigenes with an average length of 1312 bp. A total of 805, 473, and 1037 significantly up-regulated DEGs were identified based on LP versus SP, LM versus SM, and LH versus SH, respectively. These data indicated that hepatopancreas played stronger regulatory roles than other two tissues on size differentiation in male M. nipponense. The KEGG pathway analysis indicated that pathways PI3K-Akt pathway, cAMP pathway, Hippo pathway, and Ras signaling pathway were enriched in all three comparisons, which may be key size regulators in adult male prawn M. nipponense. Furthermore, twenty-eight DEGs involved in these pathways and their expression was verified by quantitative Real-Time PCR (qPCR). These four pathways and twenty-eight predicted potential size-related genes may be strong candidates for size differentiation in adult male M. nipponense. Finding of the study have potential applications for improving the commercial size of cultured male prawn M. nipponense.

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Section: Discussionmentioning

confidence: 99%

Screening and analyzing of Genes and Signaling Pathways Associated with Size differentiation of Adult Male Prawn Macrobrachium nipponense

Zhu

Xue

et al. 2022

Preprint

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“…The poor prognosis of esophageal cancer is due to the strong proliferation, invasion and metastasis abilities of esophageal cancer cells [22][23] . It is signi cantly important to identify the genes involved in proliferation, migration and invasion for the accurate diagnosis and development of the therapeutic strategies for esophageal cancer [24][25] . It was discovered that the copy number of IGF2BP2 in tumor tissues was higher than that in adjacent normal tissues.…”

Section: Discussionmentioning

confidence: 99%

IGF2BP2 Promotes the Proliferation, Invasion and Migration of Esophageal Carcinoma Cells via Activation of the PI3K/AKT/EMT Signaling Pathway

Shu

Lin

Yan

et al. 2021

Preprint

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BackgroundInsulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IGF2BP2), as a m6A “reader”, is known to be an oncogene, and its expression is elevated in multiple tumors. However, the role of IGF2PB2 in esophageal squamous cell carcinoma (ESCC) is still unclear. MethodsThis study aims to investigate the role of IGF2PB2 expression in ESCC proliferation, invasion and migration as well as the possible mechanism. IGF2BP2 expression was found to be elevated in ESCC tissues by qRT-PCR, western blotting, and immunohistochemical (IHC) staining. ResultsKnocking down IGF2BP2 expression prevented the proliferation, invasion, migration and epithelial-mesenchymal transition (EMT) of KYSE450 and TE1 cells. Knocking out IGF2BP2 reduced tumorigenesis in vivo. Overexpression of IGF2BP2 was performed, and it was proven that IGF2BP2 had an oncogenic effect in KYSE450 and TE1 cells. Moreover, LY294002, a highly selective inhibitor of PI3K, reversed the effect of IGF2BP2 overexpression on EMT processes. All these results show that the effects of IGF2BP2 on oncogenesis and EMT were clearly exerted via the PI3K/AKT signaling pathway. ConclusionsIn conclusion, this study demonstrates that the oncogenic function of IGF2BP2 is mediated by the PI3K/AKT signaling pathway and is related to EMT in ESCC. In addition, IGF2BP2 can serve as a diagnostic and oncotherapeutic marker in further studies.

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“…Similarly, the proliferation, invasion, and migration are promoted by TRIM16 via TGF β and Snail pathway, which regulates epithelial-mesenchymal transition in esophageal cancer cell lines [ 80 ]. Smurf2 acts as a ubiquitin ligase for Smad, and its expression is higher in tumor cells, mainly at the tumor front, where the proliferation in esophageal squamous cell carcinoma is higher [ 146 ].…”

Section: Role Of Ubiquitin-proteasome Pathway In Cancermentioning

confidence: 99%

Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling

Sharma

Khan

Singh

et al. 2021

IJMS

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The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is widely known for its role in degrading abnormal protein substrates and maintaining physiological body functions via ubiquitinating enzymes (E1, E2, E3) and the proteasome. Therefore, aberrant expression in these enzymes results in an altered biological process, including transduction signaling for cell death and survival, resulting in cancer. In this review, an overview of profuse enzymes involved as a pro-oncogenic or progressive growth factor in tumors with their downstream signaling pathways has been discussed. A systematic literature review of PubMed, Medline, Bentham, Scopus, and EMBASE (Elsevier) databases was carried out to understand the nature of the extensive work done on modulation of ubiquitin-proteasome pathways in oncogenic signaling. Various in vitro, in vivo studies demonstrating the involvement of ubiquitin-proteasome systems in varied types of cancers and the downstream signaling pathways involved are also discussed in the current review. Several inhibitors of E1, E2, E3, deubiquitinase enzymes and proteasome have been applied for treating cancer. Some of these drugs have exhibited successful outcomes in in vivo studies on different cancer types, so clinical trials are going on for these inhibitors. This review mainly focuses on certain ubiquitin-proteasome enzymes involved in developing cancers and certain enzymes that can be targeted to treat cancer.

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RASSF6-TRIM16 axis promotes cell proliferation, migration and invasion in esophageal squamous cell carcinoma

Cited by 14 publications

References 34 publications

Screening and analyzing of Genes and Signaling Pathways Associated with Size differentiation of Adult Male Prawn Macrobrachium nipponense

Screening and analyzing of Genes and Signaling Pathways Associated with Size differentiation of Adult Male Prawn Macrobrachium nipponense

IGF2BP2 Promotes the Proliferation, Invasion and Migration of Esophageal Carcinoma Cells via Activation of the PI3K/AKT/EMT Signaling Pathway

Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling

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