Rat estrous cycle influences the sexual diergism of HPA axis stimulation by nicotine

Rhodes, Michael E.; Kennell, Jamilyn S.; Belz, Emily E.; Czambel, R. Kenneth; Rubín, Robert T.

doi:10.1016/j.brainresbull.2004.06.011

Cited by 32 publications

(26 citation statements)

References 45 publications

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“…In male rats, the AVP response was higher, while female rats secreted more ACTH and corticosterone (Rhodes et al, 2001). Furthermore, ACTH and corticosterone responses to medium nicotine doses vary with estrous cycle of female rats, showing highest increases in the proestrus and estrus phase (Rhodes et al, 2004).…”

Section: Dose-dependency and Threshold Level Of Nicotinementioning

confidence: 96%

The hypothalamic–pituitary–adrenal (HPA) axis in habitual smokers

Rohleder

Kirschbaum

2006

International Journal of Psychophysiology

240

167

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Section: Dose-dependency and Threshold Level Of Nicotinementioning

confidence: 96%

The hypothalamic–pituitary–adrenal (HPA) axis in habitual smokers

Rohleder

Kirschbaum

2006

International Journal of Psychophysiology

240

167

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“…A number of studies have shown that intraperitoneal (IP) injection of saline acts as a mild stressor, resulting in modest elevations in plasma corticosterone [6,41]. In the present study, we evaluated whether daily introduction of this mild aversive stimulus prior to training would alter the effect of septal cholinergic lesions on acquisition of a DMP task.…”

Section: Introductionmentioning

confidence: 97%

Aversive stimulus attenuates impairment of acquisition in a delayed match to position T-maze task caused by a selective lesion of septo-hippocampal cholinergic projections

Fitz¹,

Gibbs²,

Johnson³

2006

Brain Research Bulletin

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Infusion of 192 IgG-saporin (SAP) into the medial septum (MS) of rats selectively destroys cholinergic neurons projecting to the hippocampus and impairs acquisition of a delayed matching to position (DMP) T-maze task. The present study evaluated whether introduction of a mild aversive stimulus 30 min prior to training would attenuate the deficit in DMP acquisition caused by the SAP lesions. Male Sprague-Dawley rats received medial septal infusions of either artificial cerebrospinal fluid or SAP (0.22 μg in 1.0 μl). Fourteen days later, all animals were trained to perform the DMP task. Half of the SAP-treated animals and controls received an intraperitoneal injection of saline each day, 30 min prior to training. Results show that intraperitoneal saline attenuated the impairment in DMP acquisition in SAP lesioned rats. These results suggest that a mild aversive stimulus can attenuate cognitive deficits caused by medial septal cholinergic lesions.

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“…The gender and estrous differences could result from higher estradiol levels and associated stressrelated HPA axis activity in females, most dramatic at proestrous and estrous stages (Miller et al, 2004;Rhodes et al, 2004). The difference in HPA activity has been tracked to circulating estrogen (Burgess and Handa, 1992).…”

Section: Sun and Alkonmentioning

confidence: 99%

Differential Gender-Related Vulnerability to Depression Induction and Converging Antidepressant Responses in Rats

Sun¹,

Alkon²

2005

J Pharmacol Exp Ther

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Vulnerability of females to depression among humans has not previously been reflected in animal models. Here, we show, by using a novel animal model of depression, that young female Wistar rats are clearly more vulnerable to depression induction than the males. This differential female vulnerability follows estrous cycle stages, is associated with cognitive impairment, and can be markedly transformed with sex hormones. Male hormone reduces vulnerability in females, whereas female hormone increases vulnerability in males. The induced depressive behavior in both sexes, however, is sensitive to imipramine and to the antagonism of the glucocorticoid receptors within a hormonal pathway previously implicated in human depression. Anisomycin, a protein synthesis inhibitor, eliminates the antidepressive effects of both antidepressants and male hormone but does not affect depression induction and estradiol-induced higher vulnerability. Moreover, direct cerebroventricular administration of brain-derived neurotrophic factor (BDNF), whose mRNA levels in the hippocampus and frontal cortex reach its lowest levels when estrogen levels are highest, is sufficient to rescue the antidepressive effects in the presence of the protein synthesis inhibitor. A selective enhancement of BDNF expression and/or BDNF signal cascades in the neural circuits controlling mood may represent an effective strategy for the development of novel antidepressants for both sexes, whereas blocking the gender-related higher vulnerability to potentially depressogenic events may lead to the development of specific antidepressants for the females.

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Rat estrous cycle influences the sexual diergism of HPA axis stimulation by nicotine

Cited by 32 publications

References 45 publications

The hypothalamic–pituitary–adrenal (HPA) axis in habitual smokers

The hypothalamic–pituitary–adrenal (HPA) axis in habitual smokers

Aversive stimulus attenuates impairment of acquisition in a delayed match to position T-maze task caused by a selective lesion of septo-hippocampal cholinergic projections

Differential Gender-Related Vulnerability to Depression Induction and Converging Antidepressant Responses in Rats

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