Rat islets are not rejected by anti‐islet antibodies in mice treated with costimulation blockade

Abstract

The presence at Tx of DSA does not appear to negatively influence early and late islet xenograft survival in mice receiving costimulation blockade.

Immunotoxicological effects of streptozotocin and alloxan: In vitro and in vivo studies

“…We also experienced that STZ-diabetic mouse recipients accepted porcine xenograft for as long as 180 days when treated with costimulation blockade reagents, i.e. anti CD154, CTLA4Ig with/without anti LFA-1 [22], while, with the same treatment, some of ALX-diabetic mouse rejected rat xenografts at around 100 days [23].…”

Xenotransplantation literature update, July–August 2014

“…Diab et al. used the alloxan‐induced diabetes model in mice to test the importance of DSA to islet rejection in the presence of costimulatory blockade including anti‐CD154, CTLA4Ig, and/or anti‐LFA‐1. Mice that received costimulation blockade had almost no cellular infiltration and surprisingly showed no difference in graft survival when injected with naïve serum or xeno‐educated serum.…”