Rat neural stem cell proliferation and differentiation are durably altered by the in utero polyunsaturated fatty acid supply

Goustard-Langelier, Bénédicte; Koch, Mélanie; Lavialle, Monique; Heberden, Christine

doi:10.1016/j.jnutbio.2012.08.001

Cited by 18 publications

(15 citation statements)

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“…Emerging evidence consistently demonstrates that exosomal miRNAs can be reprogrammed by environmental factors ( Goustard-Langelier et al, 2013 ; Shah et al, 2016 ). Exosome are cell-derived small sized vesicles (40–150 nm), present in many biological fluids ( Pan et al, 1985 ; Simons and Raposo, 2009 ).…”

Section: Cell-derived Exosomes: Roles In Tumor Development and Progrementioning

confidence: 99%

“…The importance of stem cell-derived miRNAs in response to environmental factors has recently been identified ( Goustard-Langelier et al, 2013 ; Shah et al, 2016 ). Shah et al (2016) determined the effects of the chemoprotective fish oil/pectin diet on miRNAs in colonic stem cells obtained from Lgr5-EGFP-IRES-creER knock-in mice.…”

Section: Cell-derived Exosomes: Roles In Tumor Development and Progrementioning

confidence: 99%

“…They further demonstrated that only miR-19b and its indirect target PTK2B were modulated by the fish oil/pectin diet in Lgr5 (negative) cells. In addition, rat neural stem cells/neural progenitors (NSC) proliferation and differentiation were dually altered by the in utero polyunsaturated fatty acid supply, along with marked alterations in miRNA expression ( Goustard-Langelier et al, 2013 ). Although the role of exosomes in the pathogenesis of UFs is unknown, we recently isolated myometrium stem cells from adult uteri early life exposed to DES.…”

Section: Cell-derived Exosomes: Roles In Tumor Development and Progrementioning

confidence: 99%

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Early Life Adverse Environmental Exposures Increase the Risk of Uterine Fibroid Development: Role of Epigenetic Regulation

2016

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Uterine Fibroids [UF(s), AKA: leiomyoma] are the most important benign neoplastic threat to women’s health. They are the most common cause of hysterectomy imposing untold personal consequences and 100s of billions of healthcare dollars, worldwide. Currently, there is no long term effective FDA-approved medical treatment available, and surgery is the mainstay. The etiology of UFs is not fully understood. In this regard, we and others have recently reported that somatic mutations in the gene encoding the transcriptional mediator subunit Med12 are found to occur at a high frequency (∼85%) in UFs. UFs likely originate when a Med12 mutation occurs in a myometrial stem cell converting it into a tumor-forming stem cell leading to a clonal fibroid lesion. Although the molecular attributes underlying the mechanistic formation of UFs is largely unknown, a growing body of literature implicates unfavorable early life environmental exposures as potentially important contributors. Early life exposure to EDCs during sensitive windows of development can reprogram normal physiological responses and alter disease susceptibility later in life. Neonatal exposure to the EDCs such as diethylstilbestrol (DES) and genistein during reproductive tract development has been shown to increase the incidence, multiplicity and overall size of UFs in the Eker rat model, concomitantly reprogramming estrogen-responsive gene expression. Importantly, EDC exposure represses enhancer of zeste 2 (EZH2) and reduces levels of histone 3 lysine 27 trimethylation (H3K27me3) repressive mark through Estrogen receptor/Phosphatidylinositide 3-kinases/Protein kinase B non-genomic signaling in the developing uterus. Considering the fact that distinct Mediator Complex Subunit 12 (Med12) mutations are detected in different fibroid lesions in the same uterus, the emergence of each Med12 mutation is likely an independent event in an altered myometrial stem cell. It is therefore possible that a chronic reduction in DNA repair capacity eventually causes the emergence of mutations such as Med12 in myometrial stem cells converting them into fibroid tumor-forming stem cells, and thereby leads to the development of UFs. Advancing our understanding of the mechanistic role epigenetic regulation of stem cells plays in mediating risk and tumorigenesis will help in pointing the way toward the development of novel therapeutic options.

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Section: Cell-derived Exosomes: Roles In Tumor Development and Progrementioning

confidence: 99%

Section: Cell-derived Exosomes: Roles In Tumor Development and Progrementioning

confidence: 99%

Section: Cell-derived Exosomes: Roles In Tumor Development and Progrementioning

confidence: 99%

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Early Life Adverse Environmental Exposures Increase the Risk of Uterine Fibroid Development: Role of Epigenetic Regulation

2016

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“…Epidemiological studies have revealed that low n-3 PUFA is correlated with cognitive or behavioural defects during early development (75) , adulthood and ageing (76) . They also affect deeply the physiology of rat NSC, by enhancing their proliferation and differentiation, and modifying their trancriptome (82) . In 19-month-old mice, 8 weeks of n-3 supplementation led to an increase in hippocampal neurogenesis and in arborisation of newborn neurons (81) .…”

Section: Dietary Interventionsmentioning

confidence: 99%

Modulating adult neurogenesis through dietary interventions

Heberden

2016

Nutr. Res. Rev.

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Three areas in the brain continuously generate new neurons throughout life: the subventricular zone lining the lateral ventricles, the dentate gyrus in the hippocampus and the median eminence in the hypothalamus. These areas harbour neural stem cells, which contribute to neural repair by generating daughter cells that then become functional neurons or glia. Impaired neurogenesis leads to detrimental consequences, such as depression, decline of cognitive abilities and obesity. Adult neurogenesis is a versatile process that can be modulated either positively or negatively by many effectors, external or endogenous. Diet can modify neurogenesis both ways, either directly by ways of food-borne molecules, or possibly by the modifications induced on gut microbiota composition. It is therefore critical to define dietary strategies optimal for the maintenance of the stem cell pools.

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“…En el caso de la proliferación en hipocampo adulto, se sabe que las células progenitoras que son originadas en la zona subgranular del giro dentado tienen características morfológicas de células gliales (Seri et al, 2006), es decir, aún no son neuronas propiamente dichas (Cameron & McKay, 1999;Christie & Cameron, 2006;Gould, Tanapat, McEwen, Flugge & Fuchs, 1998;Jankovski, Garcia, Soriano & Sotelo, 1998;Kang et al, 2013;Pham, McEwen, LeDoux & Nader, 2005;Schoenfeld & Gould, 2013;Toriumi et al, 2012;Yau et al, 2011). El mecanismo de proliferación puede ser modificado por varios factores entre los cuales se pueden contar determinados fármacos y compuestos (Bachstetter et al, 2010;Fujita et al, 2008;Huang et al, 2012;Kauffman, 1969;Kippin, Kapur & van der Kooy, 2005;Kudo et al, 2003;Rice, Bullock & Shelton, 2004;Tung, Herrera, Fornal & Jacobs, 2008;Zusso et al, 2008), el ejercicio (Crews, Nixon & Wilkie, 2004;Itoh et al, 2011;Nam et al, 2013;Wu et al, 2008), la nutrición (Goustard-Langelier, Koch, Lavialle & Heberden, 2013;Liu & Mori, 2005), la privación de sueño y en general las alteraciones del ritmo sueño-vigilia (Guzman-Marin et al, 2003;Junek, Rusak & Semba, 2010;McEwen, 2006;Roman, van der Borght, Leemburg, Van der Zee & Meerlo, 2005;Tung, Takase, Fornal & Jacobs, 2005). Existen evidencias de que la proliferación neuronal hipocampal está relacionada con aprendizaje de tareas de cond...…”

Section: Efectos Del Estrés Sobre La Plasticidad Neuronal Y La Neurogunclassified

Efectos del estrés sobre los procesos de plasticidad y neurogénesis: una revisión

Zarate¹,

Parra²,

Acevedo-Triana

et al. 2014

Univ Psychol

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r e S u M e n Grandes esfuerzos han sido llevados a cabo para entender los componentes psicobiológicos del estrés y de algunas de las psicopatologías relacionadas con él, tales como los trastornos de ansiedad (ansiedad generalizada o crisis de pánico) e incluso la depresión. Existen evidencias de que procesos como la neurogénesis y la plasticidad se ven enormemente afectados por muchos factores, entre ellos el estrés. En esta revisión se presentan algunos de los principales conceptos sobre la relación entre estrés, plasticidad y neurogé-nesis, a los que se ha llegado a partir de investigaciones realizadas -principalmente en modelos animales-, desde hace algunas décadas. Se realizará una diferenciación entre los efectos ocasionados por estrés crónico y agudo, tratando de establecer las interacciones que sobre estos efectos ejercen algunas variables tales como el género o el rango de edad, se enfatizarán los efectos comportamentales para finalmente revisar algunas de las formas de intervención actualmente más usadas para el tratamiento del estrés. Palabras clave estrés; plasticidad; neurogénesis a B S t r a C tThere is a growing interest in the comprehension of psychobiological mechanisms underlying stress and its relationships with many psychopathologies such as anxiety (i.e. generalized anxiety and panic attacks) or depression. There are several reports on the effects of stress on neurogenesis and plasticity. This review will discuss some of the core concepts on the relation between stress, plasticity and neurogenesis obtained during the last decades from research -mainly based in the use of animal models. The distinguishable effects between acute and chronic stress will also be discussed in relation to other factors as genre and age with an emphasis on behavioral effects. Some current therapeutic approaches will be reviewed as well.

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Rat neural stem cell proliferation and differentiation are durably altered by the in utero polyunsaturated fatty acid supply

Cited by 18 publications

References 49 publications

Early Life Adverse Environmental Exposures Increase the Risk of Uterine Fibroid Development: Role of Epigenetic Regulation

Early Life Adverse Environmental Exposures Increase the Risk of Uterine Fibroid Development: Role of Epigenetic Regulation

Modulating adult neurogenesis through dietary interventions

Efectos del estrés sobre los procesos de plasticidad y neurogénesis: una revisión

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