2007
DOI: 10.4049/jimmunol.178.5.3252
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Rate of Increase in Circulating IL-7 and Loss of IL-7Rα Expression Differ in HIV-1 and HIV-2 Infections: Two Lymphopenic Diseases with Similar Hyperimmune Activation but Distinct Outcomes

Abstract: IL-7 is a nonredundant cytokine for T cell homeostasis. Circulating IL-7 levels increase in lymphopenic clinical settings, including HIV-1 infection. HIV-2 infection is considered a “natural” model of attenuated HIV disease given its much slower rate of CD4 decline than HIV-1 and limited impact on the survival of the majority of infected adults. We compared untreated HIV-1- and HIV-2-infected patients and found that the HIV-2 cohort demonstrated a delayed increase in IL-7 levels during the progressive depletio… Show more

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Cited by 31 publications
(27 citation statements)
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“…Its production is regulated by an IL-7R-mediated feedback loop, which together with the utilization by T cells determines the serum and tissue levels of the cytokine. In human lymphopenic settings, IL-7 plasma levels are increased and are thought to increase low-affinity TCR-induced proliferation and enhance survival of naive T cells (38)(39)(40). We investigated whether IL-7 influenced peripheral naive T cell numbers in DS.…”
Section: No Indication For Reduced Peripheral Generation Of Naive T Cmentioning
confidence: 99%
“…Its production is regulated by an IL-7R-mediated feedback loop, which together with the utilization by T cells determines the serum and tissue levels of the cytokine. In human lymphopenic settings, IL-7 plasma levels are increased and are thought to increase low-affinity TCR-induced proliferation and enhance survival of naive T cells (38)(39)(40). We investigated whether IL-7 influenced peripheral naive T cell numbers in DS.…”
Section: No Indication For Reduced Peripheral Generation Of Naive T Cmentioning
confidence: 99%
“…The IL-7/CD4 regulatory loop is activated in human immunodeficiency virus (HIV) infection, as indicated by increased plasma IL-7 levels that inversely correlate with CD4 ϩ T-cell counts of patients (1,13,14,28,29,39,50,51,56,68,70). Increased IL-7 secretion by bone marrow stromal cells from infected patients suggests a regulation at the level of cytokine production (34,35).…”
Section: Interleukin 7 (Il-7) Plays a Central Role In Controlling Cd4mentioning
confidence: 99%
“…2C, right graph), demonstrating that the sustained thymic function in older HIV-2-infected patients does not lead to the expected enlargement of the TREC-rich T-cell population, likely being concomitantly expanded by increased cell death and/or accelerated maturation. This is further emphasized by the absence of correlation between circulating interleukin 7 levels and sjTREC quantification in HIV-2-infected patients (1).…”
Section: Fig 1 Hiv-2-infected Patients Demonstrate High Thymic Funcmentioning
confidence: 99%
“…The factors determining the delayed disease progression in HIV-2 infection remain largely unknown (14). Although plasma viral load is much lower in HIV-2 infection than in HIV-1 infection (2), the proviral loads of HIV-2-infected patients are similar to those of HIV-1-infected patients at the same disease stage (10,11), suggesting that the two viruses do not differ significantly in their ability to establish infection and replicate in human cells (1,17).…”
mentioning
confidence: 99%