Rate of Para-Aortic Lymph Node Micrometastasis in Patients with Locally Advanced Cervical Cancer

Zand, Behrouz; Euscher, Elizabeth D.; Soliman, Pamela T.; Schmeler, Kathleen M.; Coleman, Robert L.; Jhingran, Anuja; Frumovitz, Michael; Ramondetta, Lois M.; Ramírez, Pedro T.

doi:10.1016/j.jmig.2010.08.100

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Those with stage IB2 or IIA2 often underwent neoadjuvant chemotherapy or straightforward concurrent chemoradiotherapy, and were excluded from the study. This group of women has been reported to have a higher incidence of advanced lesions such as parametrial infiltration or distant metastasis . Women who were found to have advanced lesions by radiologic examination were also excluded from the study.…”

Section: Discussionmentioning

confidence: 99%

Discrepancies between clinical staging and surgicopathologic findings in early‐stage cervical cancer and prognostic significance

Chen

Zhang

Liu

et al. 2019

Intl J Gynecology & Obste

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Objective To investigate discrepancies between clinical staging and surgicopathologic findings in early‐stage cervical cancer and explore the prognostic significance of these discrepancies. Methods A retrospective review of the clinical records of individuals with early‐stage cervical cancer who underwent primary radical surgery in Nanfang Hospital of Southern Medical University, Guangzhou, China, between 2007 and 2013. Discrepancies in clinical staging were investigated by using surgicopathologic findings as the reference. Individuals were classified according to the type of discrepancy. Kaplan‐Meier plots were generated to explore the prognostic significance of stage discrepancies. Results Among 266 individuals included in the study, 182 (68.4%) were accurately staged, 58 (21.8%) were clinically over‐staged, and 26 (9.8%) were clinically under‐staged. More relapses (19.2% vs 4.9% vs 6.8%, P=0.027) and deaths (11.5% vs 2.2% vs 3.4%, P=0.048) were observed among those who were clinically under‐staged than among those who were accurately or clinically over‐staged. Clinical under‐staging was associated with poorer disease‐free survival (P=0.003) and poorer overall survival (P=0.020) over a median follow‐up of 43.9 months. Conclusion Significant discrepancies were found between clinical staging and surgicopathologic findings in early‐stage cervical cancer. Stage discrepancies were found to have prognostic significance, with clinical under‐staging identified as a potential adverse prognostic factor.

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Section: Discussionmentioning

confidence: 99%

Discrepancies between clinical staging and surgicopathologic findings in early‐stage cervical cancer and prognostic significance

Chen

Zhang

Liu

et al. 2019

Intl J Gynecology & Obste

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“…Univariate analysis and Cox proportional hazards model analysis showed that lymph node metastasis, HSP70 protein expression and ADC mean were the independent risk factors for the recurrence of advanced cervical cancer. The presence of lymph node micro‐metastasis is an important risk factor for tumor recurrence and it is related to worse overall prognosis of cervical cancer . Moreover, several studies have revealed that over‐expression of HSP70 is associated with poor prognosis in different cancers, such as esophageal squamous cell carcinoma .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of short‐ and long‐term efficacy of chemoradiotherapy for advanced cervical cancer using HSP70 protein combined with multimodal MRI

Liu

Yin

et al. 2017

J of Cellular Biochemistry

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This study aims to evaluate the efficacy of chemoradiotherapy for advanced cervical cancer using heat shock protein 70 (HSP70) combined with multimodal MRI. The protein expressions of HSP70 in biopsy specimens obtained from 101 patients with cervical cancer were detected by immunohistochemistry. Plain MRI scan, DWI, DCE-MR, and MRS were performed before and after a period of 6 months of chemoradiotherapy. All patients were assigned into the complete response (CR) and partial response (PR) groups. HSP70 protein expression, tumor diameter, and tumor volume were lower in the CR group than in the PR group. The rate of tumor shrinkage, relative positive enhancement integral (rPEI), relative maximum slope of decrease (rMSD), relative signal enhancement ratio at 60 s (rSER ) and maximum SER (rSER ), mean apparent diffusion coefficient (ADC ) and minimum ADC value (ADC ) values in the CR group were higher than those in the PR group. Tumor diameter and volume, rSER and rSER were reduced after chemoradiotherapy, while rMSD, rSER , time to peak (TTP), ADC and ADC were higher after the treatment. The receiver operating characteristic (ROC) curves indicated that HSP70 expression, tumor diameter, rPEI, ADC and Cho peak showed the better chemoradiotherapy efficacy. Our data demonstrates that HSP70 protein combined with multimodal MRI may accurately evaluate the chemoradiotherapy efficacy of patients with advanced cervical cancer. The recurrence of cervical cancer significantly decreased in patients with negative expression of HSP70 and HSP70 protein detection provides potential therapy for the prevention, diagnosis, and prognosis of cervical cancer.

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“…La valeur prédictive négative ganglionnaire lombo-aortique de la TEP/TDM varie de 94 à 83 % dans la littérature avec toutefois des performances diminuées pour les métastases ganglionnaires de petite taille 5 mm (Tableau 4) [10,11,[33][34][35][36][37]. Selon les études, l'incidence des micrométastases est évaluée entre 2 à 8 % [38,39].…”

Section: Discussionunclassified

Valeur pronostique de la TEP/TDM dans le bilan initial du cancer du col utérin : SUVmax de la tumeur primitive et stadification ganglionnaire

et al. 2014

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Objectif.-L'objectif principal était d'évaluer la valeur pronostique de la fixation de 18 F-fluorodéoxyglucose de la tumeur primitive mesurée par la Standardized Uptake Value (SUV max) définie par la tomographie par émission de positons (TEP) dans le cancer du col utérin. L'objectif secondaire était de déterminer les performances diagnostiques de la TEP pour la stadification ganglionnaire pelvienne et lombo-aortique. Méthode.-Nous avons inclus, rétrospectivement, 49 patientes présentant un cancer cervical utérin de stade FIGO IB1-IVB. La valeur pronostique de la SUV max a été recherchée par une analyse univariée. La survie a été analysée par la méthode de Kaplan-Meier. L'analyse histologique des ganglions était le gold standard. Résultats.-Une différence significative des SUV max tumorales était observée entre le stade I et II, le stade I et IVet la taille de la tumeur 4 cm et > 4 cm (p = 0,0001). Il existait une corrélation entre la SUV max et le grand axe de la tumeur (r = 0,597) (p < 0,0001). L'envahissement ganglionnaire pelvien était prédictif de la survie sans progression (p = 0,0007). La valeur prédictive négative (VPN) de la TEP pour les ganglions lombo-aortiques (n = 24) était de 100 % dans les stades IB2-IVA. La spécificité et la VPN pour les ganglions pelviens (n = 8) étaient de 100 % et 87,5 % (7/8), respectivement, dans les stades précoces. Le ganglion faussement négatif mesurait moins de 2 mm. Conclusion.-Nos résultats démontrent une corrélation entre la SUV max et le grand axe tumoral, qui représente un indicateur de l'agressivité tumorale. La TEP a une bonne VPN pour la stadification ganglionnaire lombo-aortique dans les stades localement avancés. Elle reste cependant insuffisante pour prédire l'atteinte ganglionnaire pelvienne et ne permet pas d'éviter la lymphadénectomie dans les stades précoces.

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Rate of Para-Aortic Lymph Node Micrometastasis in Patients with Locally Advanced Cervical Cancer

Cited by 3 publications

References 14 publications

Discrepancies between clinical staging and surgicopathologic findings in early‐stage cervical cancer and prognostic significance

Discrepancies between clinical staging and surgicopathologic findings in early‐stage cervical cancer and prognostic significance

Evaluation of short‐ and long‐term efficacy of chemoradiotherapy for advanced cervical cancer using HSP70 protein combined with multimodal MRI

Valeur pronostique de la TEP/TDM dans le bilan initial du cancer du col utérin : SUVmax de la tumeur primitive et stadification ganglionnaire

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