Ratiometric fluorescent nanoprobes for visual detection: Design principles and recent advances - A review

Bigdeli, Arafeh; Ghasemi, Forough; Abbasi-Moayed, Samira; Shahrajabian, Maryam; Fahimi-Kashani, Nafiseh; Jafarinejad, Somayeh; Nejad, Mohammad Amin Farahmand; Hormozi-Nezhad, M. Reza

doi:10.1016/j.aca.2019.06.035

Cited by 296 publications

(135 citation statements)

References 185 publications

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“…Because of these merits, there have been successful instances of the application of the fluorescent technique in clinical diagnostics, biotechnology, biochemistry and molecular biology, materials and environmental sciences (Mason 1999). It has been used for the monitoring of diverse groups of analytes including heavy metal ions, explosives, peptides, and pesticides (Bigdeli et al 2019).…”

Section: The Fluorescence Colourimetric and Ratiometric Optical Detmentioning

confidence: 99%

“…The ratiometric detection approach has been put in place to overcome some sensitivity difficulties usually encountered in optical detection (e.g. interference from a variety of analyte-independent factors, including instrumental parameters, the probe's microenvironment, the probe's local concentration, and photobleaching) (Bigdeli et al 2019;Lee et al 2015). Ratiometric fluorescence detection method affords the possibility of simultaneous recording of two measurable signals in the presence and absence of analyte (Grynkiewicz et al 1985).…”

Section: The Fluorescence Colourimetric and Ratiometric Optical Detmentioning

confidence: 99%

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Fluorescent, colourimetric, and ratiometric probes based on diverse fluorophore motifs for mercuric(II) ion (Hg2+) sensing: highlights from 2011 to 2019

Aderinto

2020

Chem. Pap.

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Though it has not been shown to deliver any biological importance, mercuric(II) ion (Hg 2+) is a deleterious cation which poses grievous effects to the human body and/or the ecosystem, hence, the need for its sensitive and selective monitoring in both environmental and biological systems. Over the years, there has been a great deal of work in the use of fluorescent, colourimetric, and/or ratiometric probes for Hg 2+ recognition. Essentially, the purpose of this review article is to give an overview of the advances made in the constructions of such probes based on the works reported in the period from 2011 to 2019. Discussion in this review work has been tailored to the kinds of fluorophore scaffolds used for the constructions of the probes reported. Selected examples of probes under each fluorophore subcategory were discussed with mentions of the typically determined parameters in an analytical sensing operation, including modulation in fluorescence intensity, optimal pH, detection limit, and association constant. The environmental and biological application ends of the probes were also touched where necessary. Important generalisations and conclusions were given at the end of the review. This review article highlights 196 references. Keywords Mercuric(II) ion (Hg 2+) • Fluorescent probes • Colourimetric probes • Ratiometric probes • Hg 2+-selective probes • Sensing

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Section: The Fluorescence Colourimetric and Ratiometric Optical Detmentioning

confidence: 99%

Section: The Fluorescence Colourimetric and Ratiometric Optical Detmentioning

confidence: 99%

Fluorescent, colourimetric, and ratiometric probes based on diverse fluorophore motifs for mercuric(II) ion (Hg2+) sensing: highlights from 2011 to 2019

Aderinto

2020

Chem. Pap.

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“…Electrons are transferred from the highest occupied molecular orbital (HOMO) of the acceptor (or donor) to the semi-occupied molecular orbital (SOMO) of the fluorophore (or acceptor), resulting in fluorescence quenching. However, if the non-bonded electron pair of the donor is combined with the analyte, the redox potential of the donor increases, and the HOMO energy is lower than the fluorophore, which will cause the fluorescence to be switched on, and that limits the PET process [19,20].…”

Section: Photoinduced Electron Transfer (Pet)mentioning

confidence: 99%

Biological nanoscale fluorescent probes: From structure and performance to bioimaging

Wan

Zhang

et al. 2020

Reviews in Analytical Chemistry

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In recent years, nanomaterials have attracted lots of attention from researchers due to their unique properties. Nanometer fluorescent materials, such as organic dyes, semiconductor quantum dots (QDs), metal nano-clusters (MNCs), carbon dots (CDs), etc., are widely used in biological imaging due to their high sensitivity, short response time, and excellent accuracy. Nanometer fluorescent probes can not only perform in vitro imaging of organisms but also achieve in vivo imaging. This provides medical staff with great convenience in cancer treatment. Combined with contemporary medical methods, faster and more effective treatment of cancer is achievable. This article explains the response mechanism of three-nanometer fluorescent probes: the principle of induced electron transfer (PET), the principle of fluorescence resonance energy transfer (FRET), and the principle of intramolecular charge transfer (ICT), showing the semiconductor QDs, precious MNCs, and CDs. The excellent performance of the three kinds of nano fluorescent materials in biological imaging is highlighted, and the application of these three kinds of nano fluorescent probes in targeted biological imaging is also introduced. Nanometer fluorescent materials will show their significance in the field of biomedicine.

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“…In reference mode, a fluorescence channel without a signal change in the presence of target analytes acts as a reference and another channel with signal increase/decrease/shift upon analyte's presence as a signal reporter. In dynamic mode, two dynamic channels with signal changes in opposite or same directions with the exist of analytes were applied [76]. Fluorescent organic dyes [77], lanthanide elements [78], and quantum dots [79,80] could be employed to design RF-based sensors.…”

Section: Ratiometric Measurementmentioning

confidence: 99%

Recent advances in fluorescence probes based on carbon dots for sensing and speciation of heavy metals

2020

Nanophotonics

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Heavy metal (HM) pollution is a major global concern. Carbon dots (CDs) have demonstrated unique properties as sensing platforms for HMs detection. This review summarizes the progress made in recent years in fluorescence methods to determine HMs and their species using CDs. First, the strategies to synthesize and purify CDs are reviewed. The photoluminescence principles of CDs and their sensing mechanisms as HMs sensors are then summarized. The binding strategies between CDs and HMs are proposed to provide salient principles to design desirable CD-based HMs sensors. The preparation and merits of “turn-on” and ratiometric CDs for HMs detection with higher accuracy are discussed compared with commonly used “turn-off” sensors. Subsequently, the progress on detecting single HM ions, multi-HMs, and different metal species in solution, and the development of gel/solid-state sensor platforms such as paper-based devices, sensor arrays, hydrogels, polymer films, and ion-imprinted polymers are critically accessed. Furthermore, the advances in the cell, bacterial, plant, and animal bioimaging of HMs with CDs as promising bioimaging reagents are presented. Finally, the challenges and prospects of CDs as HMs sensors in future investigations are discussed.

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Ratiometric fluorescent nanoprobes for visual detection: Design principles and recent advances - A review

Cited by 296 publications

References 185 publications

Fluorescent, colourimetric, and ratiometric probes based on diverse fluorophore motifs for mercuric(II) ion (Hg2+) sensing: highlights from 2011 to 2019

Fluorescent, colourimetric, and ratiometric probes based on diverse fluorophore motifs for mercuric(II) ion (Hg2+) sensing: highlights from 2011 to 2019

Biological nanoscale fluorescent probes: From structure and performance to bioimaging

Recent advances in fluorescence probes based on carbon dots for sensing and speciation of heavy metals

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