Rational design in functional hydrogels towards biotherapeutics

Yang, Yang; Ren, Yuqing; Song, Wei; Yu, Bohong; Liu, Hongzhuo

doi:10.1016/j.matdes.2022.111086

Cited by 15 publications

(6 citation statements)

References 191 publications

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“…Adhesion : hydrogel matrices are known as inherently hydrated materials, and their adhesion depends on sparse and loose adhesive junctions that are surrounded by water ( Yang. et al, 2022 ).…”

Section: Hydrogels and Spinal Cord Repairmentioning

confidence: 99%

“…Most authors in their research even indicate some functional features of an ideal hydrogel: ➢ Colorless, odourless, absolutely non-toxic ( Marin et al, 2013 ); ➢ The highest capacity for biological degradation without toxic substances formation after degradation. For example, PLGA hydrogel, which was approved by the FDA, however, its degradation products (obtained in vivo ) turned out to be toxic, which significantly limits its clinical use ( Oliva et al, 2017 ); ➢ pH neutrality after swelling in water ( Li et al, 2018 ); ➢ The highest strength and stability in a swelling environment and during storage ( Bashir et al, 2020 ); ➢ Ability (if necessary) to rewet: hydrogel must be able to dehydrate the solution or retain it; depending on application requirements ( Ahmed, 2015 ; Yang et al, 2022 ); ➢ The greatest capacity for hydration (maximum equilibrium swelling) in physiological solution ( Bashir et al, 2020 ); ➢ The highest absorbency under load (AUL) ( Chai et al, 2017 ); ➢ Desired absorption rate (desired particle size and porosity) depending on application requirements ( Nicodemus and Bryant, 2008 ; Slaughter et al, 2009 ); ➢ The lowest soluble content and residual monomer ( Bashir et al, 2020 ); ➢ Photostability ( Bashir et al, 2020 ; Yang et al, 2022 ). …”

Section: Hydrogels and Spinal Cord Repairmentioning

confidence: 99%

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Modern advances in spinal cord regeneration: hydrogel combined with neural stem cells

Rybachuk,

Nesterenko,

Zhovannyk

2024

Front. Pharmacol.

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Severe spinal cord injuries (SCI) lead to loss of functional activity of the body below the injury site, affect a person’s ability to self-care and have a direct impact on performance. Due to the structural features and functional role of the spinal cord in the body, the consequences of SCI cannot be completely overcome at the expense of endogenous regenerative potential and, developing over time, lead to severe complications years after injury. Thus, the primary task of this type of injury treatment is to create artificial conditions for the regenerative growth of damaged nerve fibers through the area of the SCI. Solving this problem is possible using tissue neuroengineering involving the technology of replacing the natural tissue environment with synthetic matrices (for example, hydrogels) in combination with stem cells, in particular, neural/progenitor stem cells (NSPCs). This approach can provide maximum stimulation and support for the regenerative growth of axons of damaged neurons and their myelination. In this review, we consider the currently available options for improving the condition after SCI (use of NSC transplantation or/and replacement of the damaged area of the SCI with a matrix, specifically a hydrogel). We emphasise the expediency and effectiveness of the hydrogel matrix + NSCs complex system used for the reconstruction of spinal cord tissue after injury. Since such a complex approach (a combination of tissue engineering and cell therapy), in our opinion, allows not only to creation of conditions for supporting endogenous regeneration or mechanical reconstruction of the spinal cord, but also to strengthen endogenous regeneration, prevent the spread of the inflammatory process, and promote the restoration of lost reflex, motor and sensory functions of the injured area of spinal cord.

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Section: Hydrogels and Spinal Cord Repairmentioning

confidence: 99%

Section: Hydrogels and Spinal Cord Repairmentioning

confidence: 99%

Modern advances in spinal cord regeneration: hydrogel combined with neural stem cells

Rybachuk,

Nesterenko,

Zhovannyk

2024

Front. Pharmacol.

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“…When hydrogels are used as interface material between a bioelectronic device and biological tissue, controlling the adhesion to both parts is crucial. The abundant functional groups present on biological tissues such as hydroxyl, carboxylic acid, thiol and amino groups can be leveraged to anchor the hydrogel via chemical or physical bonds (Yang et al, 2022). Physical binding…”

Section: Adhesionmentioning

confidence: 99%

Integration of hydrogels in microfabrication processes for bioelectronic medicine: Progress and outlook

Saghir

Imenes

Schiavone

2023

Front. Bioeng. Biotechnol.

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Recent research aiming at the development of electroceuticals for the treatment of medical conditions such as degenerative diseases, cardiac arrhythmia and chronic pain, has given rise to microfabricated implanted bioelectronic devices capable of interacting with host biological tissues in synergistic modalities. Owing to their multimodal affinity to biological tissues, hydrogels have emerged as promising interface materials for bioelectronic devices. Here, we review the state-of-the-art and forefront in the techniques used by research groups for the integration of hydrogels into the microfabrication processes of bioelectronic devices, and present the manufacturability challenges to unlock their further clinical deployment.

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“…The last two decades have seen a growing trend towards a variety of advanced wound dressings, such as alginate dressings [3], polymeric film dressings [4], hydrocolloid dressings [5], and hydrogel dressings [6]. Of particular concern, hydrogel wound dressings are considered to be the most competitive advanced wound dressing material [7]. This is because, on the one hand, hydrogel wound dressings have created a big medical market [8].…”

Section: Introductionmentioning

confidence: 99%

Advances in Functional Hydrogel Wound Dressings: A Review

et al. 2023

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One of the most advanced, promising, and commercially viable research issues in the world of hydrogel dressing is gaining functionality to achieve improved therapeutic impact or even intelligent wound repair. In addition to the merits of ordinary hydrogel dressings, functional hydrogel dressings can adjust their chemical/physical properties to satisfy different wound types, carry out the corresponding reactions to actively create a healing environment conducive to wound repair, and can also control drug release to provide a long-lasting benefit. Although a lot of in-depth research has been conducted over the last few decades, very few studies have been properly summarized. In order to give researchers a basic blueprint for designing functional hydrogel dressings and to motivate them to develop ever-more intelligent wound dressings, we summarized the development of functional hydrogel dressings in recent years, as well as the current situation and future trends, in light of their preparation mechanisms and functional effects.

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Rational design in functional hydrogels towards biotherapeutics

Cited by 15 publications

References 191 publications

Modern advances in spinal cord regeneration: hydrogel combined with neural stem cells

Modern advances in spinal cord regeneration: hydrogel combined with neural stem cells

Integration of hydrogels in microfabrication processes for bioelectronic medicine: Progress and outlook

Advances in Functional Hydrogel Wound Dressings: A Review

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