Rational Estimation of the Optimum Amount of Non‐Fibrous Disintegrant Applying Percolation Theory for Binary fast Disintegrating Formulation

Roller compaction of different pseudopolymorphic forms of Theophylline: Effect on compressibility and tablet properties

“…whether direct compaction or roller compaction was used). In a previous work of our research group (Krausbauer et al, 2008) geometrical description of heterogeneous ensembles like pharmaceutical formulations for solid dosage forms were taken into account in order to calculate the percolation thresholds of such disordered particulate systems. Geometrical phase transitions are independent of chemical properties of the components and percolation theory is the most suitable tool to predict and simulate these transitions.…”

Materials Science Tetrahedron—A Useful Tool for Pharmaceutical Research and Development

“…Appropriate processes can be readily developed based on such understanding to deliver desired performance. Following its initial introduction to pharmaceutical literature in 1980s,94, 95 the percolation theory has been shown useful in understanding powder compaction behavior of mixtures and in guiding tablet formulation design 96–104. More extensive applications of the percolation theory should contribute enormously to scientific formulation and process development.…”

Effects of compatibilizers on the mechanical properties and interfacial tension of polypropylene and poly(lactic acid) blends

“…[3][4][5] Blending of biodegradable polymers induces gradual decomposition of conventional polymers and the phenomenon is named at biodisintegration. [6][7][8][9][10][11] Poly(lactic acid) (PLA) is an unstable material which can be decomposed easily by various types of impurities. It especially reacts with water and it is converted to lactic acid, and the lactic acid is biodegraded by microbes.…”