Rationale and design for the CARDIOVIT Study (Cardiovit, Atherosclerotic vascular disease and hypeRhomocysteinemia:an epiDemiological study in Indians, additionally evaluating the effect of Oral VITamin supplementation)

Abstract

CARDIOVIT is one of the first and largest studies in India to provide insight into the prevalence of hypertHcy, its association with AVD and conventional risk factors and the role of multivitamins in reducing it.

Role of Zinc and Selenium in Oxidative Stress and Immunosenescence: Implications for Healthy Aging and Longevity

“…In agreement with the protective role of selenium a Sweden study performed in 668 elderly subjects showed that persons with serum Se in the lowest quartile had 43% and 56% increased risk for all-cause and cardiovascular mortality, respectively (Alehagen et al 2016). This confirms the reduced incidence of cardiovascular diseases observed in previous studies after supplementation with selenium combined in multivitamins supplements (Czernichow et al 2005;Shenoy et al 2006). There is also evidence that a number of HIV-positive patients suffer from deficiencies in vitamins including selenium (Coodley 1995).…”

Isolated abducens nerve palsy with hyperhomocysteinemia: Association and outcomes

“…Population based randomized trials such as CARDIOVIT study,[7] are underway to investigate the association of hyperhomocysteinemia with systemic vaso-occlusive diseases. Until conclusive data is available it is recommended to investigate and treat for hyperhomocysteinemia in cases of vaso-occlusive diseases.…”

Hyperhomocysteinemia and Low Methionine Stress Are Risk Factors for Central Retinal Venous Occlusion in an Indian Population

“…Similar reports stating a high prevalence of HHcys in the Indian population are available. [31][32][33][34][35] Young Asian Indian men settled in the United States and Europe have also been reported to exhibit HHcys. 36 -39 In our study, methionine was significantly lower (P ϭ 0.001) in the patients with CRVO, with no significant change in the levels of cysteine and glutathione, showing that there is probably a defect in the transmethylation pathway rather than transsulfuration pathway.…”