Rationale, design, methodology and hospital characteristics of the first gulf acute heart failure registry (gulf care)

Abstract

Background:There is paucity of data on heart failure (HF) in the Gulf Middle East. The present paper describes the rationale, design, methodology and hospital characteristics of the first Gulf acute heart failure registry (Gulf CARE).Materials and Methods:Gulf CARE is a prospective, multicenter, multinational registry of patients >18 year of age admitted with diagnosis of acute HF (AHF). The data collected included demographics, clinical characteristics, etiology, precipitating factors, management and outcomes of patients admitted with AHF. In addition, data about hospital readmission rates, procedures and mortality at 3 months and 1-year follow-up were recorded. Hospital characteristics and care provider details were collected. Data were entered in a dedicated website using an electronic case record form.Results:A total of 5005 consecutive patients were enrolled from February 14, 2012 to November 13, 2012. Forty-seven hospitals in 7 Gulf States (Oman, Saudi Arabia, Yemen, Kuwait, United Gulf Emirates, Qatar and Bahrain) participated in the project. The majority of hospitals were community hospitals (46%; 22/47) followed by non-University teaching (32%; 15/47 and University hospitals (17%). Most of the hospitals had intensive or coronary care unit facilities (93%; 44/47) with 59% (28/47) having catheterization laboratory facilities. However, only 29% (14/47) had a dedicated HF clinic facility. Most patients (71%) were cared for by a cardiologist.Conclusions:Gulf CARE is the first prospective registry of AHF in the Middle East, intending to provide a unique insight into the demographics, etiology, management and outcomes of AHF in the Middle East. HF management in the Middle East is predominantly provided by cardiologists. The data obtained from this registry will help the local clinicians to identify the deficiencies in HF management as well as provide a platform to implement evidence based preventive and treatment strategies to reduce the burden of HF in this region.

The importance of the First Jordanian Percutaneous Coronary Intervention Registry

“…[56] The mean age of patients in this heart failure registry was a decade younger with a high prevalence of diabetes mellitus (DM) when compared to their Western counterparts, which is also consistent with the findings from Gulf RACE and Gulf RACE-2 registries. [34]…”

“…[67] The Gulf Registry of Acute Coronary Events (Gulf RACE) (conducted in 2007 and included 8169 patients) and Gulf RACE-2 (conducted in 2009 and included 7939 patients) were on Middle Eastern patients and from the GCC states, namely, Bahrain, Saudi Arabia, Kuwait, Qatar, Oman, the United Arab Emirates, and Yemen. [3] Gulf RACE-2 had 1-year follow-up.…”

Incidence and impact of cardiorenal anaemia syndrome on all‐cause mortality in acute heart failure patients stratified by left ventricular ejection fraction in the Middle East

“…5 Briefly, men and women ≥ 18 year of age, admitted (from 14 February 2012 to 14 November 2012) to the participating hospitals with an admission diagnosis of AHF, were recruited. The registry design, methods, and collected clinical variables have been described elsewhere.…”

Myocardial reverse remodeling: how far can we rewind?

“…Apparently, the phosphorylation of cMyBP-C is able to modulate diastolic function (10, 41, 222, 237) (Fig. 3) by enhancing cardiac lusitropy whereas the absence of phosphorylation depresses lusitropy (226). cMyBP-C can be phosphorylated by different kinases known to be altered in HFpEF, including PKA (77), PKC (270), and CaMK-II (202).…”