“…Indeed, the most remarkable cytotoxic effects throughout our project have been detected in ER BC models in vitro, which roughly reflect the characteristics of luminal BCC in vivo, a widespread aggressive tumor in women [87,129,130,[138][139][140][141]145]. Interestingly, these findings are consistent with many reports showing for ruthenium complexes significant antiproliferative effects against specific subtypes of BC [124]. Thus, starting from these data, to expand knowledge for an optimal Ru-based candidate drugs development as chemotherapeutic options, we have next focused on selected in vitro models of BC-i.e., MCF-7, CG-5, MDA-MB-231, MDA-MB-468, and MDA-MB-436 cell lines-with distinct phenotypic and/or genotypic features, and different replicative and/or invasive potential.…”