2009
DOI: 10.3945/jn.109.105858
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Rats Fed Fructose-Enriched Diets Have Characteristics of Nonalcoholic Hepatic Steatosis

Abstract: Nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease are increasing in adults and are likely to be increasing in children. Both conditions are hepatic manifestations of metabolic syndrome. Experimental animals fed fructose-enriched diets are widely recognized as good models for metabolic syndrome. However, few reports have described the hepatic pathology of these experimental animals. In this study, 5-wk-old Wistar specific pathogen-free rats, which are a normal strain, were fed experimenta… Show more

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Cited by 171 publications
(147 citation statements)
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“…The non significant changes in different nutritional parameters in the present study are similar to the results reported by Kawasaki et al (2009) and Al-Okbi et al (2013) when rats fed similar high fructose diets without a glucosamine injection were compared with balanced diets. The significant reduction in final body weight, body weight gain and food efficiency ratio on administration of Nigella crude oil agreed with previous results (Al-Okbi et al, 1997;Houcher et al, 2007).…”
Section: Discussionsupporting
confidence: 80%
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“…The non significant changes in different nutritional parameters in the present study are similar to the results reported by Kawasaki et al (2009) and Al-Okbi et al (2013) when rats fed similar high fructose diets without a glucosamine injection were compared with balanced diets. The significant reduction in final body weight, body weight gain and food efficiency ratio on administration of Nigella crude oil agreed with previous results (Al-Okbi et al, 1997;Houcher et al, 2007).…”
Section: Discussionsupporting
confidence: 80%
“…Rats with MHRS showed a significant elevation in all liver fat with dyslipidemia which may be due to feeding high fructose as described by Kawasaki et al (2009) andAl-Okbi et al (2013). Nigella sativa oil showed previously to produce a hepatoprotective effect in rats (Al-Suhaimi, 2012) which was confirmed by the work of Al-Okbi et al (2013), who reported its protective effect against steatohepatitis.…”
Section: Discussionsupporting
confidence: 71%
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“…Skala degenerasi lemak kemudian dihitung secara semikuantitatif dalam 5 lapang pandang berbeda dengan kriteria penilaian adalah skor 0=tidak terdapat hepatosit yang mengalami degenerasi lemak; skor 1=<10% hepatosit yang mengalami degenerasi lemak; skor 2=10-33% hepatosit mengalami degenerasi lemak; skor 3=34-66% hepatosit yang mengalami degenerasi lemak; skor 4=>66-100% hepatosit yang mengalami degenerasi lemak. 11 Data diuji dengan one way ANOVA dan post-hoc LSD. Hipotesis bermakna bila p<0,050.…”
Section: Metodeunclassified