Rattlesnake venom components in the control of experimental autoimmune encephalomyelitis: Immunomodulatory properties potentiated by silica SBA-15

Sant’Anna, Morena Brazil; Giardini, Aline Carolina; Lopes, Flávia Souza Ribeiro; Kimura, Louise F.; Chacur, Marucia; Pagano, Rosana L.; Zambelli, Vanessa O.; Sant’Anna, Osvaldo A.; Picolo, Gisele

doi:10.1016/j.toxicon.2020.04.054

Cited by 1 publication

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“…It was also noted that this nanosystem helped to improve the efficacy of CTX to treat multiple sclerosis because it reduced the proliferation of peripheral T helper cells 17 that characterize autoimmune, inflammatory diseases and cancer [ 20 ]. Crotalphine is a 14 amino acid analgesic peptide that, like CTX, trapped in SBA-15 MSNs was capable of increasing its therapeutic action, attenuating the inflammation induced by EAE because it reduced the immunoreactivity of Egr-1 markers, microglia/macrophages and astrocytes [ 101 ]. This information indicates the nanobiotechnological potential of both macromolecules and their protection and transport system, against the treatment of neurodegenerative diseases, control of sensitivity, motor alterations, atrophy, and loss of motor function [ 101 ].…”

Section: Nanosystems and Nanocarriersmentioning

confidence: 99%

“…Crotalphine is a 14 amino acid analgesic peptide that, like CTX, trapped in SBA-15 MSNs was capable of increasing its therapeutic action, attenuating the inflammation induced by EAE because it reduced the immunoreactivity of Egr-1 markers, microglia/macrophages and astrocytes [ 101 ]. This information indicates the nanobiotechnological potential of both macromolecules and their protection and transport system, against the treatment of neurodegenerative diseases, control of sensitivity, motor alterations, atrophy, and loss of motor function [ 101 ]. Another study revealed that CTX-SBA-15 MSNs have a long-lasting contraceptive effect, as this nanoencapsulated system releases the CTX polypeptide in a controlled manner, which could be beneficial for use as new oral or injectable contraceptives [ 36 ].…”

Section: Nanosystems and Nanocarriersmentioning

confidence: 99%

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Nanobiotechnology with Therapeutically Relevant Macromolecules from Animal Venoms: Venoms, Toxins, and Antimicrobial Peptides

et al. 2022

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Some diseases of uncontrolled proliferation such as cancer, as well as infectious diseases, are the main cause of death in the world, and their causative agents have rapidly developed resistance to the various existing treatments, making them even more dangerous. Thereby, the discovery of new therapeutic agents is a challenge promoted by the World Health Organization (WHO). Biomacromolecules, isolated or synthesized from a natural template, have therapeutic properties which have not yet been fully studied, and represent an unexplored potential in the search for new drugs. These substances, starting from conglomerates of proteins and other substances such as animal venoms, or from minor substances such as bioactive peptides, help fight diseases or counteract harmful effects. The high effectiveness of these biomacromolecules makes them promising substances for obtaining new drugs; however, their low bioavailability or stability in biological systems is a challenge to be overcome in the coming years with the help of nanotechnology. The objective of this review article is to describe the relationship between the structure and function of biomacromolecules of animal origin that have applications already described using nanotechnology and targeted delivery.

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Section: Nanosystems and Nanocarriersmentioning

confidence: 99%