2023
DOI: 10.1038/s41422-022-00752-5
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RBP–RNA interactions in the control of autoimmunity and autoinflammation

Abstract: Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory responses toward self-components, contributing to various autoimmune diseases and autoinflammatory diseases. RNA-binding proteins (RBPs) are essential for immune cell development and function, mainly via exerting post-transcriptional regulation of RNA metabolism and function. Functional dysregulation of RBPs and abnormities in RNA metabolism are closely associated with multiple autoimmune or autoinflammatory disorders. Distinc… Show more

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Cited by 36 publications
(14 citation statements)
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“…HEK293 T cells were used to produce lentivirus according to a previously developed protocol. 3 Specifically, 600 ng of backbone plasmid, 400 ng of PAX2 plasmid, and 200 ng of VSV-G plasmid were codelivered into HEK293 T cells in 12well plates with 3.6 μL of PEI (1 μg/μL, Polysciences, 24765-1). Conditioned medium containing lentivirus was collected 48 h post-transfection and used immediately to infect cells or frozen at −80 °C.…”
Section: ■ Concluding Remarksmentioning
confidence: 99%
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“…HEK293 T cells were used to produce lentivirus according to a previously developed protocol. 3 Specifically, 600 ng of backbone plasmid, 400 ng of PAX2 plasmid, and 200 ng of VSV-G plasmid were codelivered into HEK293 T cells in 12well plates with 3.6 μL of PEI (1 μg/μL, Polysciences, 24765-1). Conditioned medium containing lentivirus was collected 48 h post-transfection and used immediately to infect cells or frozen at −80 °C.…”
Section: ■ Concluding Remarksmentioning
confidence: 99%
“…2 Molecular regulation mediated by RNA−RBP interactions is essential to cellular homeostasis and normal physiology, and perturbations of such interactions can cause cellular dysfunction and disease such as autoimmunity and cancer. 3,4 Targeting RNA−RBP interactions has become a promising avenue for disease treatment. 5 Canonical RBPs contain RNA-binding domains (RBDs) that bind RNA substrates by recognizing specific nucleotide sequences or regulatory elements.…”
Section: ■ Introductionmentioning
confidence: 99%
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“…In a broad sense, the RBP roles of hnRNPs establish them as a lynchpin in regulating the expressions of specific genes associated with autoimmune disorders, especially in coordination with mRNAs and lncRNAs (Liu & Cao, 2023; Lodde et al, 2023). On the one hand, hnRNPs may play critical parts in RNA metabolisms and mediate the pathogenesis of autoimmune diseases by targeting the phenotype‐specific susceptibility or functional genes.…”
Section: Hnrnps Regulate Gene Expressions Contributing To Inflammatio...mentioning
confidence: 99%
“…Given their critical role in post-transcriptional gene regulation, the dysregulation of their functions has been implicated in various diseases and pathological conditions, including neurodegenerative diseases and neurological disorders [ 28 , 29 , 30 , 31 , 32 , 33 ], various cancers [ 23 , 34 , 35 , 36 , 37 ], autoimmune diseases [ 38 , 39 ], viral infection and/or replication [ 40 , 41 , 42 , 43 , 44 ] and inflammatory disorders [ 45 , 46 , 47 , 48 ]. Much attention has therefore been paid to better understanding their involvement in molecular and cellular events and processes, and their relationship with human physio(patho)logy.…”
Section: Introductionmentioning
confidence: 99%