2007
DOI: 10.1111/j.1365-2443.2007.01089.x
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RBP2 is an MRG15 complex component and down‐regulates intragenic histone H3 lysine 4 methylation

Abstract: MRG15 is a conserved chromodomain protein that associates with histone deacetylases (HDACs

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Cited by 92 publications
(116 citation statements)
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“…Some other proteins or modifications might participate in the regulation of splicing events of Tpm1, Prm1, and Prm2 mRNAs. Because MRG15 can interact with HAT, HDAC complexes, and other histone modifications, such as methylated H4K20, localization of MRG15 on the genome may be regulated by not only H3K36me3 but also, other histone modifications and/or protein complexes (13)(14)(15)(16)(17)(18)(19)(20)(21)26). PTBPs are known to antagonize exon definition; therefore, those retained sequences could be recognized as an exon on the absence of MRG15 (44).…”
Section: Discussionmentioning
confidence: 99%
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“…Some other proteins or modifications might participate in the regulation of splicing events of Tpm1, Prm1, and Prm2 mRNAs. Because MRG15 can interact with HAT, HDAC complexes, and other histone modifications, such as methylated H4K20, localization of MRG15 on the genome may be regulated by not only H3K36me3 but also, other histone modifications and/or protein complexes (13)(14)(15)(16)(17)(18)(19)(20)(21)26). PTBPs are known to antagonize exon definition; therefore, those retained sequences could be recognized as an exon on the absence of MRG15 (44).…”
Section: Discussionmentioning
confidence: 99%
“…During spermatogenesis, histone H4 is highly acetylated before replacement of nucleosomal proteins from histones to TNPs to protamines (27). Because MRG15 is found in both HAT and HDAC complexes (13)(14)(15)(16)(17)(18)(19)(20)(21), MRG15 may be essential for postmeiotic events. To investigate whether MRG15 is involved in histone acetylation in postmeiotic spermatogenesis, acetylated histones were analyzed.…”
Section: Spermatogenesis In Mrg15mentioning
confidence: 99%
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“…KDM5 family members contain an evolutionarily conserved JmjC domain and were found to possess histone demethylase activities that target histone H3 lysine 4 (3,11,14,17,22). As trimethylation at this site (H3K4me3) is highly associated with transcriptional start sites of actively transcribed genes, KDM5 members are thought to regulate the expression of genes encoding developmental regulators.…”
mentioning
confidence: 99%
“…It is widely accepted that the histone-modifying enzymes are assembled into multisubunit complexes that enable the coordinated action of distinct activities to efficiently regulate chromatin remodeling (23,24). Human KDM5A has been identified in SIN3B-containing histone deacetylase (HDAC) 2 complexes (22), suggesting that its demethylation activity is tightly linked with histone deacetylation processes. The SIN3B-HDAC complex also contains MRG15, a chromodomain protein that binds to H3 methylatedat lysine 36 (H3K36me) (25), implying functional interplay between H3K4me3 and H3K36me.…”
mentioning
confidence: 99%