RdxA Diversity and Mutations Associated with Metronidazole Resistance of
            <i>Helicobacter pylori</i>

Gong, Yanan; Zhai, Kangle; Sun, Lu; He, Lihua; Wang, Hairui; Guo, Yafei; Zhang, Jianzhong

doi:10.1128/spectrum.03903-22

Cited by 13 publications

(3 citation statements)

References 37 publications

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“…RdxA protein of H. pylori catalyses the reduction of metronidazole to form hydroxylamine which is a potent mutagen that is toxic to H. pylori . Mutation in rdxA leads to the development of metronidazole resistance [ 25 ]. Cathelicidin (LL-37) and Tilapia piscidin (TP4) showed similar HADDOCK score of −94.2 kcal/mol and −93.5 kcal/mol, respectively to RdxA protein.…”

Section: Resultsmentioning

confidence: 99%

Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach

Hanafiah,

Abd Aziz,

Md Nesran

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach

Hanafiah,

Abd Aziz,

Md Nesran

et al. 2024

Heliyon

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“…Metronidazole resistance in H. pylori is primarily due to decreased drug activation mediated by mutations in RdxA gene which encodes an oxygen-insensitive NAD(P)H nitroreductase. 70 71 72 73 74 75 76 Mutations involving the FrxA gene were also reported. 35 74 77 However, metronidazole resistance was observed in H. pylori isolates without the loss of functional RdxA and FrxA, suggesting that other factors are involved in metronidazole resistance.…”

Section: Molecular Mechanisms Of Antibiotic Resistancementioning

confidence: 99%

Antibiotic Resistance of Helicobacter pylori: Mechanisms and Clinical Implications

Hasanuzzaman,

Bang,

Gong

2024

J Korean Med Sci

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Helicobacter pylori is a pathogenic bacterium associated with various gastrointestinal diseases, including chronic gastritis, peptic ulcers, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. The increasing rates of H. pylori antibiotic resistance and the emergence of multidrug-resistant strains pose significant challenges to its treatment. This comprehensive review explores the mechanisms underlying the resistance of H. pylori to commonly used antibiotics and the clinical implications of antibiotic resistance. Additionally, potential strategies for overcoming antibiotic resistance are discussed. These approaches aim to improve the treatment outcomes of H. pylori infections while minimizing the development of antibiotic resistance. The continuous evolution of treatment perspectives and ongoing research in this field are crucial for effectively combating this challenging infection.

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“…Knowledge of molecular mechanisms of antibiotic resistance could help to develop new strategies [22]. Increasing resistance to metronidazole negatively affects the effectivity of H. pylori eradication, and an increase of the dose is recommended to overcome the high level of resistance [23][24][25]. The inclusion of nitazoxanide in the main clarithromycin-based treatment regimen leads to the success of eradication therapy [26].…”

Section: Geographic Distribution Of Helicobacter Pylori Resistance To...mentioning

confidence: 99%

Epidemiology of Helicobacter pylori Resistance to Antibiotics (A Narrative Review)

Mladenova

2023

Antibiotics

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Helicobacter pylori (H. pylori) is the most common bacterial infection worldwide and one of the main etiological factors of chronic gastritis, peptic ulcer disease, and stomach neoplasms. The mass application of antibiotics without testing, especially during the last years of the pandemic of SARS-CoV-2, could lead to a dramatic increase in antibiotic resistance and reduced effectiveness of eradication regimens for H. pylori infection. The epidemiology of H. pylori resistance to antibiotics still has unclear mechanisms. Antibiotic policy should be intensified to optimize treatment, and regular monitoring of resistance of H. pylori in different geographical regions should be conducted. Individualized treatment according to susceptibility testing is strongly advisable, and the best treatment regimens should be selected. The mutations in the genes encoding the antibiotic target protein are significant risk factors for H. pylori resistance. Iatrogenic errors in diagnosis and prescribing treatment for the failure of H. pylori eradication are other important risk factors. The low level of awareness and compliance with the correct treatment influence the rate of H. pylori resistance. Epidemiological surveillance of antibiotic resistance and the adoption of new treatment strategies are needed. The discovery of an efficient vaccine against H. pylori could reduce the pressure of the world’s growing antibiotic resistance.

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RdxA Diversity and Mutations Associated with Metronidazole Resistance of Helicobacter pylori

Cited by 13 publications

References 37 publications

Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach

Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach

Antibiotic Resistance of Helicobacter pylori: Mechanisms and Clinical Implications

Epidemiology of Helicobacter pylori Resistance to Antibiotics (A Narrative Review)

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