{Re^IIICl₃} Core Complexes with Bifunctional Single Amino Acid Chelates

Abstract

The reactions of the Re(V) starting material [ReO(PPh(3))(2)Cl(3)] with ligands of the type XN(Y)Z [X = Y = 2-pyridylmethyl, Z = -CH(2)CO(2)Et (L(1)Et), -CH(2)CH(2)CO(2)Et (L(2)Et), -CH(2)CH(2)CH(2)CH(2)CH(NHCO(2)Bu(t))CO(2)H (L(3)H); X = 2-pyridylmethyl, Y = 2-(1-methylimidazolyl)methyl, Z = -CH(2)CO(2)Et (L(4)Et)] yielded the Re(III) trichloride complexes of the type [ReCl(3)(L(n)R)]. The complexes are mononuclear, paramagnetic species with a facial geometry of the chloride ligands. The nitrogen donors of the tridentate L(n)()R ligands complete the distorted octahedral coordination spheres of the complexes. Crystal data: [ReCl(3)(L(1)Et)] (1), monoclinic, C2/m, a = 16.088(3) A, b = 9.980(2) A, c = 12.829(2) A, beta = 91.384(3) degrees, Z = 4, D(calc) = 1.967 g/cm(-)(3); [ReCl(3)(L(4)Et)] (4), monoclinic, C2/c, a = 22.880(1) A, b = 7.4926(4) A, c = 22.560(1) A, beta = 94.186(1) degrees, Z = 8, D(calc) = 2.001 g/cm(-3).

The Chemistry of Technetium–Water Complexes within the Manganese Triad: Challenges and Perspectives

“…So-called single amino acid chelates (SAAC) were incorporated in the targeting fMLF sequence and then used for in vitro screening. [96][97][98] A selection of the discussed targeting agents are shown in Scheme 6.…”

Functionalised Tris(pyrazolyl)methane Ligands and Re(CO)3 Complexes Thereof

“…[30][31][32] This is interesting for therapeutic as well as diagnostic purposes as rhenium has two isotopes with favourable β-emitting properties ( 188 Re, t ½ = 16.9 h, E β = 2.1 MeV; 186 Re, t ½ = 3.78 d, E β = 1.07 MeV, E γ = 137 keV) and additionally, the Re(CO) 3 core resembles the diagnostically important 99m Tc(CO) 3 core. [18,[33][34][35][36][37][38] For the attachment of the ligands to e.g. a polymeric backbone, an additional functional group has to be present in the molecule.…”

Microwave-Assisted Synthesis of Organometallic Complexes of 99mTc(CO)3 and Re(CO)3: Its Application to Radiopharmaceuticals

“…7,8) In the synthesis of 99m Tc(CO) 3 -PAMA complexes, PAMA has been incorporated as an ester form in a reaction with a bioactive ligand, followed by hydrolysis of the resulting intermediate, and subsequent formation of a chelate with the metal ion by heating. However, it was pointed out that decomposition of the bioactive ligand during the hydrolysis and the long reaction process decrease the chemical yield and reproducibility.…”