Reactions Involving Oxygenases

Gamenara, Daniela; Seoane, Gustavo; Saenz‐Méndez, Patricia; Marı́a, Pablo Domı́nguez de

doi:10.1002/9781118409343.ch4

Cited by 1 publication

(2 citation statements)

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“…Due to the stability of this enzyme, its crystal structure has been obtained, and its catalytic mechanism has been elucidated. The first crystal structure of phenylacetone monooxygenases not only provides deep insight into the mechanism of enzymatic Baeyer–Villiger oxidations but also enables structure-guided protein engineering to broaden the substrates scope . Phenylacetone monooxygenases mostly accept aromatic ketones such as phenylacetone and 4-hydroxyacetophenone; however, they are not able to oxidize cyclohexanone .…”

Section: Homogeneous Oxygenase-catalyzed Oxygenationsmentioning

confidence: 99%

“…Phenylacetone monooxygenases mostly accept aromatic ketones such as phenylacetone and 4-hydroxyacetophenone; however, they are not able to oxidize cyclohexanone . Comprehensive reviews on BVMOs catalysis, including their application in organic synthesis and the elucidation of their crystal structure as well as mechanistic studies, are available. − Therefore, this part will only give an overview of representative synthetic applications of BVMOs and present some of the latest interesting findings.…”

Section: Homogeneous Oxygenase-catalyzed Oxygenationsmentioning

confidence: 99%

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Homogeneous Oxygenase Catalysis

et al. 2018

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Oxygenases-catalyzed reductive activation of molecular oxygen and incorporation of O atoms into an organic molecule is undoubtedly one of the most attractive research areas. Typically, these oxygenation reactions proceed with high selectivity and reactivity, which is seldom found in its "biomimetic" chemocatalytic counterparts. Furthermore, enzymatic oxygenation can avoid undesired overoxidation, which is frequently observed in (industrial) chemical transformation. Therefore, it is not surprising that tremendous attention has been paid to enzymatic oxygenation. Their application in organic synthesis has been steadily growing over the years. The goal of the present Review is to provide a handy reference for chemists interested in using homogeneous oxygenase catalysis and those interested in discovering new types of biomimetic oxidations and oxygenations with dioxygen. In this Review, we will review the recent advances in in homogeneous oxygenase catalysis to reveal the great achievements and potentials in this field.

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Section: Homogeneous Oxygenase-catalyzed Oxygenationsmentioning

confidence: 99%