Reactions to Bioabsorbable Suture Thread Embedded in Rat Subcutaneous Tissue

Abstract

We examined the subcutaneous tissue reactions in rats to bioabsorbable suture thread using histopathological methods. Using Wister rats, Vicryl ® , a bioabsorbable suture thread, was embedded into the subcutaneous tissue and histopathological examination was carried out after 4 weeks. Cholesterin crystals were used for the control. Furthermore, immunohistochemistry for CD68 was done. Histopathological examination showed proliferation of granulation tissues in both experimental and control groups. The majority of cells in the granulation tissues were macrophages and giant cells. Fibroblasts were also observed in the proliferating granulation tissues surrounding the embedded bioabsorbable suture thread. Immunohistochemistry revealed that macrophages and giant cells were positive to CD68. The results suggest that the embedded bioabsorbable suture thread is not only fabricated to undergo absorption but also for phagocytosis by macrophages and foreign body giant cells.

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“…The modified sericin thread is more readily absorbed by the tissues after surgery, reducing the need for secondary surgery. Vicryl thread 89,90 is an absorbable suture made of modified polylactic acid (PLA) and sericin. It is gradually absorbed into the tissue after surgery, reducing irritation and inflammatory reactions and eliminating the need for secondary thread removal after surgery.…”