The structure of 16-26 O is investigated within the relativistic mean field (RMF) as well as high-energy nuclear collisions. The reaction cross-sections of 16-24 O +12 C around 1 GeV are calculated within the multiple scattering theory, where the multiple integrals are evaluated by Monte Carlo method as well as by the optical limit approximation of the Glauber model. In-medium effects are investigated within the optical limit, where it is found to be important in order to get reliable information about nuclear radii and density distributions. The reaction cross-sections indicate to a halo structure for 23 O . This neutron halo is also found in the rms matter radii and nuclear densities especially when Fermi shape is used in the optical limit, including in-medium effects, in extracting the parameters of the density distributions from the experimental reaction cross-sections.