Reactive compatibilizer mediated precise synthesis and application of stimuli responsive polysaccharides-polycaprolactone amphiphilic co-network gels

Bera, Anupam; Nutan, Bhingaradiya; Jewrajka, Suresh K.

doi:10.1016/j.polymer.2016.07.033

Cited by 34 publications

(29 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The introduction of these hydrophobic segments reduces the amount of water absorbed in equilibrium by APCNs when these materials are placed in aqueous media, but, more importantly, it also constitutes the driving force for the nanophase separation of APCNs in water. The formation of a hydrophobic nanophase and a hydrophilic one within aqueous APCNs is their most characteristic property, forming the basis for their emerging applications as materials for use as antifouling coatings (size of hydrophobic and hydrophilic domains not large enough to allow strong adherence of bacteria), and as matrices for the delivery of both hydrophobic and hydrophilic drugs . Especially hydrophobic drugs can benefit from a sustained release from the nanometer‐sized hydrophobic domains within the hydrophilic network.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Amphiphilic Polymer Conetworks Based on Interconnected Hydrophobic Star Block Copolymers: Synthesis and Characterization

Kepola

Kyriacou

Patrickios

et al. 2017

Macromolecular Symposia

View full text Add to dashboard Cite

Summary Herein we report on the preparation and structural characterization of six amphiphilic polymer conetworks (APCN) based on end‐linked amphiphilic “core‐first” star block copolymers, comprising methyl methacrylate and 2‐(dimethylamino)ethyl methacrylate as the monomer repeating units in the hydrophobic and hydrophilic blocks, respectively. The various APCNs differed either in the arm composition or in the arm molecular weight. APCN synthesis was accomplished via the one‐pot, sequential group transfer polymerization (GTP) of cross‐linker, hydrophobic monomer, hydrophilic monomer, and cross‐linker again. The soluble precursors to the APCNs, i.e., the star homopolymers, the star block copolymers and the initial cross‐linker cores, were characterized in terms of their composition, size and size dispersity. The degrees of swelling in tetrahydrofuran were found to increase with the molecular weight of the arms of the stars of the APCNs, whereas the degrees of swelling in water increased with the content in hydrophilic units in the arms of the constituting stars. Small‐angle neutron scattering (SANS) indicated that most APCNs nanophase separated in D2O. The structure and size of the hydrophobic domains determined by fitting the SANS data to an appropriate model could be correlated with the molecular architecture of the APCNs. Finally, polarized light microscopy showed that all APCNs were birefringent both in water and in the dried state.

show abstract

Section: Introductionmentioning

confidence: 99%

“…More hydrophobic APCN samples swell less in water, thus exposing any defects to only a smaller extent, favoring morphologies with longer‐range order. Such more regular morphologies will result in APCNs better‐suited for all above‐mentioned applications …”

Section: Introductionmentioning

confidence: 99%

Amphiphilic Polymer Conetworks Based on Interconnected Hydrophobic Star Block Copolymers: Synthesis and Characterization

Kepola

Kyriacou

Patrickios

et al. 2017

Macromolecular Symposia

View full text Add to dashboard Cite

show abstract

“…The selection of this polyester was motivated by the fact that it is a biocompatible and hydrolytically or enzymatically degradable material. It is well-known that the use of PCL-based polymer materials is widespread in the biomedical field, such as in scaffolds [ 22 ] or amphiphilic co-networks [ 23 , 24 , 25 ]. In addition, its main degradation product (6-hydroxyhexanoic acid) is easily transformed into adipic acid [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Biodegradable and Biocompatible Thermoplastic Poly(Ester-Urethane)s Based on Poly(ε-Caprolactone) and Novel 1,3-Propanediol Bis(4-Isocyanatobenzoate) Diisocyanate: Synthesis and Characterization

et al. 2022

View full text Add to dashboard Cite

A series of non-toxic biodegradable and biocompatible polyurethanes bearing p-aminobenzoate moieties are presented. The introduction of this attractive motif was carried out by the synthesis of a novel isocyanate. These biodegradable polymers were chemically and physically characterized by several techniques and methods including bioassay and water uptake measurements. The molecular weight of the soft segment (poly-ε-caprolactone, PCL) and hard segment crystallinity dictated the mechanical behavior and water uptake. The behavior of short PCL-based polyurethanes was elastomeric, whilst increasing the molecular weight of the soft segment led to plastic polyurethanes. Water uptake was hindered for long PCL due to the crystallization of the soft segment within the polyurethane matrix. Furthermore, two different types of chain extender, hydrolyzable and non-hydrolyzable, were also evaluated: polyurethanes based on hydrolyzable chain extenders reached higher molecular weights, thus leading to a better performance than their unhydrolyzable counterparts. The good cell adhesion and cytotoxicity results demonstrated the cell viability of human osteoblasts on the surfaces of these non-toxic biodegradable polyurethanes.

show abstract

“…However, PCL and mixed with natural polymer with the help of some reactive biocompatible such as halide terminated PEG and PDMAEMA‐ b ‐PNIPAM. [ 195,196 ] It has excellent mechanical properties, such as young's modulus, impact strength, elongation, and tensile strength. In the body, polycaprolactone is degraded by the lipase enzyme and acidic pH.…”

Section: Biomaterials To Fabricate Antiadhesion Barriersmentioning

confidence: 99%

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Chandel

Shimizu

Hasegawa

et al. 2021

Macromolecular Bioscience

Self Cite

View full text Add to dashboard Cite

Postoperative peritoneal adhesion (PPA) is a prevalent incidence that generally happens during the healing process of traumatized tissues. It causes multiple severe complications such as intestinal obstruction, chronic abdominal pain, and female infertility. To prevent PPA, several antiadhesion materials and drug delivery systems composed of biomaterials are used clinically, and clinical antiadhesive is one of the important applications nowadays. In addition to several commercially available materials, like film, spray, injectable hydrogel, powder, or solution type have been energetically studied based on natural and synthetic biomaterials such as alginate, hyaluronan, cellulose, starch, chondroitin sulfate, polyethylene glycol, polylactic acid, etc. Moreover, many kinds of animal adhesion models, such as cecum abrasion models and unitary horn models, are developed to evaluate new materials’ efficacy. A new animal adhesion model based on hepatectomy and conventional animal adhesion models is recently developed and a new adhesion barrier by this new model is also developed. In summary, many kinds of materials and animal models are studied; thus, it is quite important to overview this field's current progress. Here, PPA is reviewed in terms of the species of biomaterials and animal models and several problems to be solved to develop better antiadhesion materials in the future are discussed.

show abstract

Reactive compatibilizer mediated precise synthesis and application of stimuli responsive polysaccharides-polycaprolactone amphiphilic co-network gels

Cited by 34 publications

References 43 publications

Amphiphilic Polymer Conetworks Based on Interconnected Hydrophobic Star Block Copolymers: Synthesis and Characterization

Amphiphilic Polymer Conetworks Based on Interconnected Hydrophobic Star Block Copolymers: Synthesis and Characterization

Biodegradable and Biocompatible Thermoplastic Poly(Ester-Urethane)s Based on Poly(ε-Caprolactone) and Novel 1,3-Propanediol Bis(4-Isocyanatobenzoate) Diisocyanate: Synthesis and Characterization

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Contact Info

Product

Resources

About