Reactive Eccrine Syringofibroadenoma Associated With Basal Cell Carcinoma: A Histologic Mimicker of Fibroepithelioma of Pinkus

Hays, Joshua P.; Malone, C. Helen; Goodwin, Brandon; Wagner, Richard F.

doi:10.1097/dss.0000000000001308

Cited by 9 publications

(7 citation statements)

References 4 publications

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“…15 However, other cases were reported in association with porocarcinoma 16 and basal cell carcinoma. 17 To date, this is the first case of a ESFA tumor associated with Merkel cell carcinoma excision scar. Table 1 summarizes the clinical and pathological characteristics of reported cases of reactive ESFA associated with cutaneous malignancies.…”

Section: Discussionmentioning

confidence: 85%

Reactive Eccrine Syringofibroadenoma (ESFA) in Association With a Merkel Cell Carcinoma Excision Scar

Salah

Czelusta

Sánchez³

2022

The American Journal of Dermatopathology

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:Eccrine syringofibroadenoma (ESFA) is a rare benign skin adnexal lesion of the acrosyringium of eccrine sweat ducts. Reactive ESFA, a subtype of ESFA, is usually associated with non-neoplastic cutaneous dermatoses or neoplastic skin tumors. Clinically, the lesions can be solitary or multiple, pink, or skin-colored coalescing papules or nodules of variable sizes. Histopathologically, this tumor is composed of numerous anastomosing cords of monomorphic cuboidal epithelial cells with eccrine duct formation. The association of reactive ESFA with benign conditions, such as psoriasis, diabetic polyneuropathy, scars, and leprosy, has been reported. However, the association of reactive ESFA with malignant tumors is extremely rare, with very few cases reported in the literature. We present a case of a 72-year-old woman who developed reactive ESFA associated with Merkel cell carcinoma excision scar. The ESFA tumors developed in the area of the surgical graft 10 months after the Merkel cell carcinoma had been excised. New ESFA tumors have continued to appear in the scar on a yearly basis while, so far, has been no recurrence of the original tumor. However, the presence of new tumor growths in the area suggested the possibility of recurrence of the Merkel cell carcinoma. That possibility was enhanced by the fact that PET scans revealed hypermetabolic activity in the ESFA papules.

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Section: Discussionmentioning

confidence: 85%

Reactive Eccrine Syringofibroadenoma (ESFA) in Association With a Merkel Cell Carcinoma Excision Scar

Salah

Czelusta

Sánchez³

2022

The American Journal of Dermatopathology

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“…The common subtypes include solitary ESFA, multiple ESFA associated with hidrotic ectodermal dysplasia, multiple ESFA without associated cutaneous findings, unilateral linear ESFA, and reactive ESFA. ESFA could be reactive to ulcer, scar, venous stasis, bullous pemphigoid, eccrine poroma, and squamous cell carcinoma 3 …”

Section: Discussionmentioning

confidence: 99%

Cobblestone‐like plaques on the cicatricial lower extremity resembling elephantiasis

et al. 2023

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“…Reactive ESFA, first described in 1997 by French 5 is a rare ESFA subtype associated with various inflammatory dermatoses or neoplasms. Venous stasis and ulceration is the most common dermatoses reported to be associated with ESFA 6 , and others include trauma, hyperkeratotic eczema, burn scars, lichen planus, elephantiasis, bullous pemphigoid, eccrine poroma, and hidroacanthoma simplex 4,6 . Even among the rare cases of reactive ESFA, ESFA associated with malignant neoplasm is extremely rare and there have been only 18 cases including the present case in the literature to date (Table 1) 3,4,6-16 .…”

Section: Discussionmentioning

confidence: 99%

Eccrine Syringofibroadenoma Associated with Bowen's Disease: A Case Report and Review of the Literature

2020

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Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal neoplasm which usually manifests as a solitary nodule on the extremities of elderly patients. Few case reports have described an association between ESFA and carcinomas including squamous cell carcinoma, porocarcinoma, and basal cell carcinoma. A 66-year-old male presented with a pruritic, erythematous brownish solitary plaque with crusted and verrucous surface on the extensor side of the right thigh. The lesion developed 6 to 7 years ago, and had been growing slowly. Biopsy revealed anastomosing epithelial strands which were composed of 2 areas: the upper area consisting of dysplastic cells with prominent nucleoli and abundant mitoses, and the lower area consisting of oval and round cells, and occasionally small luminal ducts. Dysplastic cells comprised almost the entire epidermis but did not invade into the dermis. Benign syringofibroadenomatous lesion surrounded the dysplastic cells in the lowermost portion of the epidermis. Although it is still unclear whether ESFA undergoes malignant transformation or it is a reactive change to carcinoma, complete excision should be performed to prevent malignant transformation with unknown risk. (Ann Dermatol 32(1) 57∼63, 2020

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Reactive Eccrine Syringofibroadenoma Associated With Basal Cell Carcinoma: A Histologic Mimicker of Fibroepithelioma of Pinkus

Cited by 9 publications

References 4 publications

Reactive Eccrine Syringofibroadenoma (ESFA) in Association With a Merkel Cell Carcinoma Excision Scar

Reactive Eccrine Syringofibroadenoma (ESFA) in Association With a Merkel Cell Carcinoma Excision Scar

Cobblestone‐like plaques on the cicatricial lower extremity resembling elephantiasis

Eccrine Syringofibroadenoma Associated with Bowen's Disease: A Case Report and Review of the Literature

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