2020
DOI: 10.1093/ajcp/aqaa227
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Reactive Eosinophil Proliferations in Tissue and the Lymphocytic Variant of Hypereosinophilic Syndrome

Abstract: Objectives The 2019 Society for Hematopathology and European Association for Haematopathology Workshop reviewed the spectrum of neoplastic, nonneoplastic, and borderline entities associated with reactive eosinophilia in tissue. Methods The workshop panel reviewed 46 cases covered in 2 workshop sessions. Results The 46 cases were presented with their consensus… Show more

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Cited by 16 publications
(16 citation statements)
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“…Patients with LV-HES rarely suffer from palpable purpura and the indurated plaques described in the presented case [30]. In doubtful cases, staining with TFH markers on lymph node biopsy should aid the correct diagnosis [29]. Unfortunately, at that time, such immunofluorescence markers for TFH cells were unavailable in the hospital where the patient was treated.…”
Section: Discussionmentioning
confidence: 85%
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“…Patients with LV-HES rarely suffer from palpable purpura and the indurated plaques described in the presented case [30]. In doubtful cases, staining with TFH markers on lymph node biopsy should aid the correct diagnosis [29]. Unfortunately, at that time, such immunofluorescence markers for TFH cells were unavailable in the hospital where the patient was treated.…”
Section: Discussionmentioning
confidence: 85%
“…Most patients have elevated IgE [28]. Skin histology is often uncharacteristic, and morphologic changes in the lymph nodes could mimic AITL [29]. Thus, the differential diagnosis with AITL is not always easy.…”
Section: Discussionmentioning
confidence: 99%
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“…Nevertheless, further investigation of non-invasive indicators reflecting active intrarenal inflammation is still needed (21). Eosinophilia is a common manifestation of IgG4-RD and is believed to be a sign of an enhanced immune response (19,22). Renal eosinophilic infiltration is also frequently observed pathologically in IgG4-RKD.…”
Section: Discussionmentioning
confidence: 99%
“…parasitic infections, autoimmune diseases, atopy, or drugs) and other explanations for organ dysfunction. 1 Confirming HES requires a combination of blood and bone marrow morphological review, cytogenetics, flow cytometry and T-cell clonality studies. 2 The lymphocyte variant of HES subtype (L-HES) is a reactive HES characterised by an immunophenotypically aberrant clonal T-cell population that overproduces eosinophil-promoting cytokines, such as interleukin-4 (IL-4) and IL-5.…”
mentioning
confidence: 99%