Reactive Oxygen Species Generation and Atherosclerosis

Nowak, Witold; Deng, Jiacheng; Ruan, Xiong Z.; Xu, Qingbo

doi:10.1161/atvbaha.117.309228

Cited by 136 publications

(97 citation statements)

References 124 publications

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“…In the meantime, the recruitment of SMCs is vital to stabilize the newly formed endothelium 32, 39, 40, 41, 42. In this study, we have demonstrated that the inclusion of 7A, especially the phosphorylated version 7Ap, significantly increased endothelialization.…”

Section: Discussionmentioning

confidence: 53%

Histone Deacetylase 7‐Derived Peptides Play a Vital Role in Vascular Repair and Regeneration

et al. 2018

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Cardiovascular disease is a leading cause of morbidity and mortality globally. Accumulating evidence indicates that local resident stem/progenitor cells play an important role in vascular regeneration. Recently, it is demonstrated that a histone deacetylase 7‐derived 7‐amino acid peptide (7A, MHSPGAD) is critical in modulating the mobilization and orientated differentiation of these stem/progenitor cells. Here, its therapeutic efficacy in vascular repair and regeneration is evaluated. In vitro functional analyses reveal that the 7A peptide, in particular phosphorylated 7A (7Ap, MH[pSer]PGAD), could increase stem cell antigen‐1 positive (Sca1+) vascular progenitor cell (VPC) migration and differentiation toward an endothelial cell lineage. Furthermore, local delivery of 7A as well as 7Ap could enhance angiogenesis and ameliorate vascular injury in ischaemic tissues; these findings are confirmed in a femoral artery injury model and a hindlimb ischaemia model, respectively. Importantly, sustained delivery of 7A, especially 7Ap, from tissue‐engineered vascular grafts could attract Sca1+‐VPC cells into the grafts, contributing to endothelialization and intima/media formation in the vascular graft. These results suggest that this novel type of peptides has great translational potential in vascular regenerative medicine.

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Section: Discussionmentioning

confidence: 53%

Histone Deacetylase 7‐Derived Peptides Play a Vital Role in Vascular Repair and Regeneration

et al. 2018

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“…26 These apparent dual roles of ROS again teach us a renewed recognition of physiologically relevant ROS as a significant endogenous signaling molecule, providing a clue for the development of better therapeutic strategies aiming at reducing pathological ROS (eg, isoform-or site-specific inhibitors of NADPH oxidase). See a review by Nowak et al 27 for further discussion on cell-specific roles of ROS.…”

Section: Reactive Oxygen Speciesmentioning

confidence: 99%

Endothelial Functions

Godo

Shimokawa

2017

ATVB

394

258

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e108T he endothelium plays important roles in modulating vascular tone by synthesizing and releasing an array of endothelium-derived relaxing factors, including vasodilator prostaglandins, NO, and endothelium-dependent hyperpolarization (EDH) factors, as well as endothelium-derived contracting factors.1,2 Such redundant mechanisms, like endogenous hyperglycemic hormones, are advantageous for ensuring proper maintenance of vascular tone under pathological conditions, where one of the vasoactive factor-mediated responses is compromised favoring a vasoconstrictor, prothrombotic, and proinflammatory state. Endothelial dysfunction is mainly caused by reduced production or action of endothelium-derived relaxing factors and could be an initial step toward cardiovascular disease.1 Indeed, evaluation of endothelial functions in humans has attracted much attention in the clinical settings because it serves as an excellent surrogate marker of cardiovascular events. For instance, endothelial dysfunction, as evaluated by impaired flow-mediated dilation of the brachial artery or digital reactive hyperemia index in peripheral arterial tonometry, is associated with future cardiovascular events in patients with coronary artery disease, 3-5 and 1-SD decrease in flow-mediated dilation or reactive hyperemia index is associated with doubling of cardiovascular event risk. 6 These observations suggest that endothelial function in peripheral vascular beds could predict future cardiovascular events.In this review, we will sum up the current advances and trends in the research on endothelial functions from bench to bedside with particular focus on recent publications in Arteriosclerosis, Thrombosis, and Vascular Biology. Earlier highlights of the journal on endothelial biology are extensively summarized in some review articles. 7-9 Emerging Modulators of Endothelial Functions Shear StressAs Lüscher and Corti 10 described in an editorial, flow is the signal of life. This physical force is sensed by the endothelium lining internal surface of the whole cardiovascular system to be translated into numerous downstream signaling pathways in a moment to moment manner in response to diverse physiological demands in the body. Indeed, shear stress is one of the important physiological cues that make endothelial cells synthesize and release endothelium-derived relaxing factors to cause relaxation of underlying vascular smooth muscle and vasodilatation. In this context, novel mechanisms of endothelial mechanotransduction in health and disease have been unveiled and summarized in a review series published recently in Arteriosclerosis, Thrombosis, and Vascular Biology. 11,12 Briefly, Zhou et al 12 emphasized the distinct roles of atheroprotective laminar or pulsatile shear stress versus atheroprone oscillatory shear stress or disturbed flow and discussed in detail the underlying molecular mechanisms that are dependent on these patterns of flow. Abe and Berk 11 further reviewed the current knowledge on the dual roles of shear stress with emphasis plac...

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“…Reactive oxygen species (ROS) is the term to indicate components that can cause oxidative stress. It includes oxygen radicals such as superoxide, hydroxyl radicals, and oxidants such as hydrogen peroxide (H 2 O 2 ) and singlet oxygen . A high level of ROS can cause oxidative modification of major cellular macromolecules (i.e., carbohydrates, lipids, proteins, and DNA).…”

Section: Disease Symptom‐associated Signals As Potential Adrs Triggersmentioning

confidence: 99%

Autonomous Drug Release Systems with Disease Symptom‐Associated Triggers

Xiong

Niu

et al. 2020

Advanced Intelligent Systems

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Many biophysical and biochemical properties of pathogenic tissues are different from those of healthy tissues. These disease symptom‐associated properties include pH, reduction–oxidation conditions, enzyme generation and expression, blood glucose concentration, mechanical stiffness and strain, and temperature. Autonomous drug release that uses one or more of these disease symptom‐associated properties as the release trigger minimizes the delay in treatments and allows for the release of medications with precisely controlled amounts and with desired spatiotemporal patterns. Herein, a comprehensive assessment of current research progress on autonomous drug release systems (ADRS) is provided. The representative symptoms‐associated properties that can be potentially used as the endogenous stimuli are introduced. The autonomous drug systems that utilize these symptom‐associated signals as the endogenous stimulation signals are discussed, followed by the discussion of current challenges and opportunities in this field, as well as possible future directions in ADRS.

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Reactive Oxygen Species Generation and Atherosclerosis

Cited by 136 publications

References 124 publications

Histone Deacetylase 7‐Derived Peptides Play a Vital Role in Vascular Repair and Regeneration

Histone Deacetylase 7‐Derived Peptides Play a Vital Role in Vascular Repair and Regeneration

Endothelial Functions

Autonomous Drug Release Systems with Disease Symptom‐Associated Triggers

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