Reactive oxygen species production by blood neutrophils of patients with laryngeal carcinoma and antioxidative enzyme activity in their blood

High perioperative level of oxidative stress as a prognostic tool for identifying patients with a high risk of recurrence of head and neck squamous cell carcinoma

“…Increased activity of antioxidative enzymes (AOE) in patients with advanced cancer of the head and neck has already been reported by Sabitha and Szuster-Ciesielska [5,17]. In accord with our findings, Szuster-Ciesielska found elevated serum GPx activity in T3/4 patients.…”

“…Intensification of antioxidative defense mechanisms is an adequate response to the profoundly elevated levels of oxidative stress that occur in advanced cancer. In addition, Szuster-Ciesielska et al [17] reported a correlation of plasma AOE activity with tumor stage in laryngeal cancer. Our results partly support her findings.…”

Myeloid-Derived Suppressor Cells in Human Cancer

“…An increased production of ROS has emerged as one of the main characteristics of MDSCs in both tumor-bearing mice and patients with cancer. 14,20,34,[55][56][57][58][59] Inhibition of ROS production by MDSCs in vitro completely abrogated the suppressive effect of these cells from mice and patients with cancer. 14,34,56…”

The emerging role of myeloid-derived suppressor cells in lung diseases

“…MDSCs in both tumour-bearing mice and patients with cancer produce ROS and inhibition of ROS production diminished the suppressive effect of MDSCs [35][36][37][38]. It has been further shown that ligation of integrins, expressed on MDSCs, contribute to increased ROS production following the interaction of MDSCs with T-cells [39].…”