Reactive oxygen species (ROS)-responsive ferrocene-polymer-based nanoparticles for controlled release of drugs

Na, Yoonhee; Lee, Jin Hyung; Woo, Jiseob; Ahn, Sukyung; Lee, Eun‐Hye; Choi, Won Il; Sung, Daekyung

doi:10.1039/c9tb02533b

Cited by 52 publications

(40 citation statements)

References 47 publications

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“…It was found from Figure 5 that the material developed by the BS does not have any effect on the generation of oxygen. At the same time, some types of polymer matrix [45,46] are involved in oxygen production. At the same time, as shown in [38], additives to the polymer matrix impair the mechanical properties of hydrogels; in our case (Figure 3), the mechanical properties practically do not depend on the mass content of nanoparticles, and strict control of the viscoelastic properties of composites for various tasks is carried out even at polymer synthesis stage.…”

Section: Discussionmentioning

confidence: 99%

New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

et al. 2021

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The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms of biomolecules has been studied. All variants of the composites significantly inhibited the division of E. coli bacteria and caused them to detach from the substrate. It was revealed that the surfaces of a composite material based on borosiloxane and ZnO NPs do not inhibit the growth and division of mammalians cells. It is shown in the work that the positive effect of the incorporation of ZnO NPs into borosiloxane can reach 100% or more, provided that the viscoelastic properties of borosiloxane with nanoparticles are retained.

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Section: Discussionmentioning

confidence: 99%

New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

et al. 2021

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“…Finally, the unloaded IB was purified by ultrafiltration at 2000 rpm for 15 min using Amicon Ultra-15 centrifugal filters (molecular weight cut-off: 100 kDa). The loading content and the loading efficiency of the nanoparticles were characterized by high-performance liquid chromatography of unloaded IB [ 30 ] and then calculated using the following equations [ 31 ]:…”

Section: Methodsmentioning

confidence: 99%

Facile Solvent-Free Preparation of Antioxidant Idebenone-Loaded Nanoparticles for Efficient Wound Healing

Yang

Kim

et al. 2022

Pharmaceutics

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The excessive production of reactive oxygen species (ROS) causes harmful effects, including biomolecular damage and inflammation. ROS due to ultraviolet rays, blue light, and fine dust harm the skin, causing urban-related aging. Therefore, a strong antioxidant that relieves oxidative stress in the skin and removes ROS is required. Idebenone (IB) is a powerful antioxidant but is poorly soluble and thus has low solubility in water, resulting in low bioavailability. In this study, IB-loaded nanoparticles (IB@NPs) were synthesized by loading IB without an organic solvent into nanoparticles that can provide high loading efficiency and stability for solubilization. Indeed, the synthesized IB@NPs exhibited long-term stability through dynamic light scattering, methylene blue staining, and redispersion assays, and IB@NPs prepared with a 5 wt% IB loading content were found to be optimal. The antioxidant activity of IB@NPs evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay was significantly higher than that of unloaded IB. In addition, IB@NPs showed excellent biocompatibility, inhibited oxidative damage to mouse NIH-3T3 fibroblasts, and reduced intracellular ROS generation according to an in vitro DPPH antioxidant assay. Most notably, IB@NPs significantly promoted wound healing in vitro, as demonstrated by scratch assays. Therefore, as carriers with excellent stability, IB@NPs have potential cosmetic and pharmaceutical applications.

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“…The hydrodynamic diameter, polydispersity index (PDI), and zeta potential of ASTA@Lec NSs with different loaded ASTA content were characterized by DLS measurements using a Zetasizer instrument (ELSZ-2000, Otsuka, Osaka, Japan). Loading content (LC) of ASTA was determined using the following equation: 29 LC wt% ð Þ (2)…”

Section: Characterization Of Asta@lec Nsmentioning

confidence: 99%

<p>Potential Antioxidant and Wound Healing Effect of Nano-Liposol with High Loading Amount of Astaxanthin</p>

Oh¹,

Lee²,

Sung³

et al. 2020

IJN

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Background: Astaxanthin (ASTA), a carotenoid, is a strong antioxidant. However, its application in functional foods, pharmaceuticals, and cosmetics remains limited due to its low aqueous solubility and stability. Several different encapsulating materials have been used to improve the stability and bioavailability of ASTA; however, the currently investigated nano-carriers for ASTA require additional improvements with regard to their loading capacity and stability. Methods: In this study, we developed lecithin nano-liposol (Lec NS) as a novel carrier of ASTA using a simple emulsion evaporation method. The physicochemical characteristics including hydrodynamic diameter, polydispersity index, surface charge and morphology were analyzed by DLS and TEM. The antioxidant activity of the ASTA-loaded Lec NS (ASTA@Lec NS) was evaluated using a DPPH radical scavenging assay and in vitro antioxidant assay. The study of in vitro wound healing efficacy was carried out to observe the beneficial effect of antioxidant activity of ASTA@Lec NS on cell migration. Results: ASTA@Lec NS showed improved stability and efficacy owing to improved aqueous solubility of ASTA inside Lec NS. Both in situ and in vitro antioxidant activities of ASTA@Lec NS were higher than that of bare ASTA and Lec NS. It also exhibited strong wound healing efficacy by regulation of ROS level in in vitro cell model. Conclusion: This study revealed that the encapsulation of ASTA into Lec NS using a wet phase transfer enhanced its physiological stability and bioavailability for effective scavenging of reactive oxygen species.

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Reactive oxygen species (ROS)-responsive ferrocene-polymer-based nanoparticles for controlled release of drugs

Abstract: Ferrocene-containing nanoparticles show reversible redox activity that could trigger drug release mediated by reactive oxygen species (ROS).

Cited by 52 publications

References 47 publications

New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

Facile Solvent-Free Preparation of Antioxidant Idebenone-Loaded Nanoparticles for Efficient Wound Healing

<p>Potential Antioxidant and Wound Healing Effect of Nano-Liposol with High Loading Amount of Astaxanthin</p>

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