Reactive thrombocytosis in pulmonary tuberculosis.

Abstract

SUMMARY The incidence of reactive thrombocytosis in active pulmonary tuberculosis was studied in 122 patients. Thrombocytosis was common, platelet counts often exceeding I x 1012/1. A significant inverse correlation was noted between the mean platelet volume and the platelet count (r = -0 54, p < 0 0001). Interval estimation suggested that this relation was non-linear. Further studies were done in a small group of six patients. Platelet survival was considerably shortened, the platelets aggregated excessively in vitro, serum concentrations of thrombopoiesis stimulating activity were raised, and serotonin uptake and release were within normal limits. The degree of thrombocytosis correlated significantly with the degree of inflammation measured by the erythrocyte sedimentation rate (r = 0 40, p < 0 003) and serum C-reactive protein concentration (r = 0 35, p <0-008).Thrombocytosis occurs in many chronic inflammatory diseases, including tuberculosis.' 4 The precise stimulus for increased platelet production in reactive thrombocytosis is not clear, but it is associated with increased numbers of small megakaryocytes in the marrow,4 6 which show reduced nuclear ploidy.5 The platelets are also small,7-9 but it has recently been suggested, that this may simply reflect the thrombocytosis, as there is normally an inverse correlation between the number and volume of platelets. "' The present study was done to define reactive thrombocytosis in acute tuberculosis with particular reference to the association between the volume and number of platelets, their survival, and certain aspects of their function. Patients and methodsOne hundred and twenty two patients with pulmonary tuberculosis were studied; most were of black or mixed racial origin. Twenty were newly diagnosed and about to begin antituberculous treatment, 82 had been diagnosed recently and were already being treated, and 20 were nearing the end of a six month course of treatmeilt. A full blood count was done-in

Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis

“…Thrombocytosis in tuberculosis patients also correlates well with markers of inflammation such as serum C-reactive protein and erythrocyte sedimentation rate [19]. Platelets also show increased aggregability and mediators of thrombopoiesis are increased.…”

Comparison of platelet count in tuberculosis spine to other spine pathology

“…Although thrombocytosis and pulmonary tuberculosis has been described in literature its diagnostic significance in TB spondylitis is not well researched [9]. In fact current literature reviews do not even mention platelets count in TB spondylitis as a consideration [5,7,17].…”

“…Haematological findings from lymphocytosis, anaemia, a raised ESR and CRP are found in active tuberculosis [7,8]. Baynes et al [9] noted reactive thrombocytosis in pulmonary TB. While HIV has been shown to cause thrombocytopaenia [10].…”

The Frequency Of JAK2 V617F Gen Mutation And Its Associations With Whole Blood Count Parameters

“…Demir eksikliği bir reaktif trombositoz nedenidir. Demir eksikliği anemisi; yaşa ve cinse göre farklı etiyolojik sebeplere bağlı gelişen, eritrositlerde hipokromi ve mikrositoz, serum demirinin düşmesi ve total demir bağla-ma kapasitesinin artması ile karakterize ve dünyada en sık karşılaşılan anemidir [33]. PV'da eritrosit morfolojisi normal olmakla birlikte demir eksikliliğinin eşlik ettiği olgularda değişiklikler izlenir.…”