Reactive X (where X = O, N, S, C, Cl, Br, and I) species nanomedicine

Wang, Keyi; Mao, Weipu; Song, Xinran; Chen, Ming; Feng, Wei; Peng, Bo; Chen, Yu

doi:10.1039/d2cs00435f

Cited by 11 publications

(2 citation statements)

References 681 publications

(880 reference statements)

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“…The catalytic ability of nanoparticles toward biochemical reactions enables their various medical applications, including biological detection, disease diagnosis, and therapy, usually known as catalytic nanomedicine . In recent decades, catalytic nanomedicines have attracted significant attention because they can potentially alleviate the shortcomings of conventional small molecule drugs, such as high dosage, poor targeting, severe toxicity, side effects, and susceptibility to drug resistance.…”

Section: Free Radical Mechanismmentioning

confidence: 99%

“…Although the free radical mechanism has been widely accepted in the study of catalytic nanomedicine, it has several weak points in terms of its experimental evidence and its ability to understand the substance selectivity for nanoparticle-catalyzed reactions. Instead, these weak points do not exist in the surface chemistry mechanism, which will be discussed in detail below.…”

Section: Free Radical Mechanismmentioning

confidence: 99%

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Nonradical Surface Chemistry Mechanisms for Catalytic Nanoparticles

Zheng,

Wang,

Xingfa

2024

J. Phys. Chem. Lett.

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Section: Free Radical Mechanismmentioning

confidence: 99%

Section: Free Radical Mechanismmentioning

confidence: 99%

Nonradical Surface Chemistry Mechanisms for Catalytic Nanoparticles

Zheng,

Wang,

Xingfa

2024

J. Phys. Chem. Lett.

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Near Infrared‐Fluorescent Dinuclear Iridium(III) Nanoparticles for Immunogenic Sonodynamic Therapy

Tang,

Cui,

Wang

et al. 2024

Advanced Materials

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Dinuclear iridium(III) complexes activated by light‐inducible spatiotemporal control are emerging as promising candidates for cancer therapy. However, broader applications of current light‐activated dinuclear iridium(III) complexes are limited by the ineffective tissue penetration and undesirable feedback on guidance activation. Here, an ultrasound (US) triggered near infrared‐fluorescent dinuclear iridium(III) nanoparticle, NanoIr, is first reported to precisely and spatiotemporally inhibit tumor growth. It is demonstrated that reactive oxygen species can be generated by NanoIr upon exposure to US irradiation (NanoIr + US), thereby inducing immunogenic cell death. When combined with cisplatin, NanoIr + US elicits synergistic effects in patient‐derived tumor xenograft mice models of ovarian cancer. This work first provides a design of dinuclear iridium(III) nanoparticles for immunogenic sonodynamic therapy.

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A Se Nanoparticle/MgFe‐LDH Composite Nanosheet as a Multifunctional Platform for Osteosarcoma Eradication, Antibacterial and Bone Reconstruction

Bian,

Zhao,

et al. 2024

Advanced Science

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Despite advances in treating osteosarcoma, postoperative tumor recurrence, periprosthetic infection, and critical bone defects remain critical concerns. Herein, the growth of selenium nanoparticles (SeNPs) onto MgFe‐LDH nanosheets (LDH) is reported to develop a multifunctional nanocomposite (LDH/Se) and further modification of the nanocomposite on a bioactive glass scaffold (BGS) to obtain a versatile platform (BGS@LDH/Se) for comprehensive postoperative osteosarcoma management. The uniform dispersion of negatively charged SeNPs on the LDH surface restrains toxicity‐inducing aggregation and inactivation, thus enhancing superoxide dismutase (SOD) activation and superoxide anion radical (·O2−)‐H2O2 conversion. Meanwhile, Fe3+ within the LDH nanosheets can be reduced to Fe2+ by depleting glutathione (GSH) in the tumor microenvironments (TME), which can catalyze H2O2 into highly toxic reactive oxygen species. More importantly, incorporating SeNPs significantly promotes the anti‐bacterial and osteogenic properties of BGS@LDH/Se. Thus, the developed BGS@LDH/Se platform can simultaneously inhibit tumor recurrence and periprosthetic infection as well as promote bone regeneration, thus holding great potential for postoperative “one‐stop‐shop” management of patients who need osteosarcoma resection and scaffold implantation.

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Reactive X (where X = O, N, S, C, Cl, Br, and I) species nanomedicine

Abstract: Reactive oxygen, nitrogen, sulfur, carbonyl, chlorine, bromine, and iodine species (RXS, X = O, N, S, C, Cl, Br, and I) play important roles in normal physiological processes through governing cell signaling, immune balance, and tissue homeostasis.

Cited by 11 publications

References 681 publications

Nonradical Surface Chemistry Mechanisms for Catalytic Nanoparticles

Nonradical Surface Chemistry Mechanisms for Catalytic Nanoparticles

Near Infrared‐Fluorescent Dinuclear Iridium(III) Nanoparticles for Immunogenic Sonodynamic Therapy

A Se Nanoparticle/MgFe‐LDH Composite Nanosheet as a Multifunctional Platform for Osteosarcoma Eradication, Antibacterial and Bone Reconstruction

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