Reactivity of selenium-containing compounds with myeloperoxidase-derived chlorinating oxidants: Second-order rate constants and implications for biological damage

Carroll, Luke; Pattison, David I.; Fu, Shanlin; Schiesser, Carl H.; Davies, Michael J.; Hawkins, Clare L.

doi:10.1016/j.freeradbiomed.2015.03.029

Cited by 24 publications

(19 citation statements)

References 58 publications

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“…This suggests that there may have been a residual effect from the previous supplementation with the micronutrient in these individuals, thus justifying the sustained neutrophil count. Thus we can say that, as noted by other authors, 22,31,32 selenium usage is able to perform a beneficial role on the viability of neutrophils in patients undergoing conditions of increased oxidative stress, such as the patients we studied. It is noteworthy that new studies should be conducted to assess the function of these cells and identify whether this supplementation influences the chemotaxis and digestion of the material phagocytosed by the cell.…”

Section: Discussionsupporting

confidence: 76%

Impact of Selenium Supplementation in Neutropenia and Immunoglobulin Production in Childhood Cancer Patients

Rocha

Vieira

Beltrame

et al. 2016

Journal of Medicinal Food

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Essential to human health, selenium (Se) has enzymatic functions of fundamental importance to human biology due to its effects on DNA damage repair, its antioxidant properties, and cancer prevention. The best studied relationships between Se and the immune system is its role in the functions of neutrophils and of lymphocytes. Despite these observations, it is not yet clear by which mechanism Se is able to modify the immune status. This was a double-blind, crossover study: Group 1 received Se and Group 2 received placebo (30 days). After this, Group 1 received placebo and Group 2 received Se (30 days). Every 30 days, blood samples were collected for white blood cell count, red blood cell count, and Ig level measurement (IgA, IgG, IgE, IgM). Of the 36 patients, 17 were suffering from leukemia/lymphomas (LL) and 19 from solid tumors (ST). In the ST group's leukogram, a significant increase in neutrophils was observed after Se usage (P = .0192). During the analyzed period, Se minimized the triggering of neutropenia cases in both groups. IgA and IgG levels in ST patients were significantly higher than those identified in LL patients after Se usage (P = .0051 and P = .0055). For IgA, a significant increase in its production, after Se usage, was observed in the ST group when compared to the LL (P = .0011). The same did not occur to the IgM and IgE immunoglobulins. In our study, the supplementation with Se reduced the neutropenic cases (LL and ST patients) and reduced IgG and IgA levels in LL and increased in ST group.

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Section: Discussionsupporting

confidence: 76%

Impact of Selenium Supplementation in Neutropenia and Immunoglobulin Production in Childhood Cancer Patients

Rocha

Vieira

Beltrame

et al. 2016

Journal of Medicinal Food

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“…Selenium-containing compounds, including selenomethionine (SeMet) and 1,4-anhydro-5-seleno-D-talitol (SeTal), are potential candidates to limit oxidative damage during inflammation in vivo , on account of their high reactivity with a number of key biological oxidants, including HOCl, HOBr, HOSCN, N- chloramines, H 2 O 2 and peroxynitrous acid (ONOOH) [7], [8], [9], [10], [11]. The second-order rate constants for these reactions are some of the highest reported for biologically relevant reactions [7], [8], [9], [10], [11].…”

Section: Introductionmentioning

confidence: 99%

“…The second-order rate constants for these reactions are some of the highest reported for biologically relevant reactions [7], [8], [9], [10], [11]. The reaction of SeMet with oxidants results primarily in the formation of selenomethionine selenoxide (SeMetO), which can be subsequently reduced by thiols such as glutathione (GSH) (Reaction 1) [7], [11], [12], [13], [14], [15].…”

Section: Introductionmentioning

confidence: 99%

“…The reaction of SeMet with oxidants results primarily in the formation of selenomethionine selenoxide (SeMetO), which can be subsequently reduced by thiols such as glutathione (GSH) (Reaction (1)) [7], [11], [14], [15], [16], [17]. Other selenoxides formed on reaction of Se compounds with H 2 O 2 , can also be reduced by GSH, regenerating the parent Se compound and forming GSSG [18], [19], which provides a pathway for potentially catalytic oxidant scavenging.

italicSeMetO + 2 italicGSH \to italicSeMet + italicGSSG + H_{2} O

…”

Section: Introductionmentioning

confidence: 99%

“…There is evidence that other Se compounds, including ebselen, selenocystamine and diselenides, can interact with TrxR [22], [23], which allows catalytic reduction of peroxides and ONOOH [21], [22], [23]. This detoxification pathway may extend to MPO-derived oxidants, including HOCl and N -chloramines, that react rapidly with the Se compounds SeMet and SeTal, forming selenoxides [11].

italicSeMetO + italicNADPH \overset{italicTr italicxR}{\to} italicSeMet + {NADP}^{+} + H_{2} O

…”

Section: Introductionmentioning

confidence: 99%

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Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes

Carroll

Pattison

et al. 2017

Redox Biology

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Myeloperoxidase produces strong oxidants during the immune response to destroy invading pathogens. However, these oxidants can also cause tissue damage, which contributes to the development of numerous inflammatory diseases. Selenium containing compounds, including selenomethionine (SeMet) and 1,4-anhydro-5-seleno-D-talitol (SeTal), react rapidly with different MPO-derived oxidants to form the respective selenoxides (SeMetO and SeTalO). This study investigates the susceptibility of these selenoxides to undergo reduction back to the parent compounds by intracellular reducing systems, including glutathione (GSH) and the glutathione reductase and thioredoxin reductase systems. GSH is shown to reduce SeMetO and SeTalO, with consequent formation of GSSG with apparent second order rate constants, k2, in the range 103–104 M−1 s−1. Glutathione reductase reduces both SeMetO and SeTalO at the expense of NADPH via formation of GSSG, whereas thioredoxin reductase acts only on SeMetO. The presence of SeMet and SeTal also increased the rate at which NADPH was consumed by the glutathione reductase system in the presence of N-chloramines. In contrast, the presence of SeMet and SeTal reduced the rate of NADPH consumption by the thioredoxin reductase system after addition of N-chloramines, consistent with the rapid formation of selenoxides, but only slow reduction by thioredoxin reductase. These results support a potential role of seleno compounds to act as catalytic scavengers of MPO-derived oxidants, particularly in the presence of glutathione reductase and NADPH, assuming that sufficient plasma levels of the parent selenoether can be achieved in vivo following supplementation.

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A review on environmental selenium issues

Gebreeyessus

Zewge

2018

SN Appl. Sci.

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Selenium is an essential element since it is necessary for metabolism and is also toxic to the living things if it is consumed above the desirable limit. For instance, up to 40 µg per d of dietary selenium is essential for human health; however, consumption of a little over 400 µg per d could result in adverse physiological problems. In the environment, selenium occurs in different species; of which selenate and selenite are its most toxic forms accounting for 95% of selenium toxicity. Though, selenium fortification is important for normal human physiology in selenium deficient environments, it needs to be minimized or removed from selenium rich environmental media. Thus, its quantification is significantly important to control per limit. Currently there is advancement in the detection and quantification of selenium in environmental including the use of a Hydride Generating Atomic Absorption Spectroscopy. Due to the excess occurrences of selenium in different locations the removal techniques from geogenic or anthropogenic sources include microbial metabolism, phytoremediation, sorption, membrane separation, coagulation, ion exchange and catalytic reduction. Most of all, the microbial removal is applied in drinking water supply and in selenium recovery from wastewater sludge. Though current selenium removal from sorption studies reported better efficiency, phytoremediation appears attractive due to its field scale application advantage. However, the fate of selenium following phytoremediation remains unaddressed.

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Reactivity of selenium-containing compounds with myeloperoxidase-derived chlorinating oxidants: Second-order rate constants and implications for biological damage

Cited by 24 publications

References 58 publications

Impact of Selenium Supplementation in Neutropenia and Immunoglobulin Production in Childhood Cancer Patients

Impact of Selenium Supplementation in Neutropenia and Immunoglobulin Production in Childhood Cancer Patients

Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes

A review on environmental selenium issues

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