Real-time and in situ visualizing the details of mitochondrial fragmentation with a leakage-free fluorescent probe in living cells

Meng, Fanqing; Liu, Tiantian; Lv, Qing; He, Junyi; Niu, Jie; Gao, Peng; Yu, Xiaoqiang

doi:10.1016/j.snb.2023.134328

Sensors and Actuators B: Chemical

2023

DOI: 10.1016/j.snb.2023.134328

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Real-time and in situ visualizing the details of mitochondrial fragmentation with a leakage-free fluorescent probe in living cells

Fanqing Meng

Tiantian Liu

Qing Lv

et al.

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2024

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Substitution Effects on Subcellular Organelle Localization in Live‐cell Imaging

Ghorpade,

Soppina,

Kanvah

2024

ChemBioChem

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A series of D‐p‐A indole‐containing fluorescent probes were developed followed by an investigation of their photophysical properties and compounds' suitability for subcellular imaging in living cells. We demonstrate that the preference for mitochondrial localization was lost when morpholine was substituted, resulting in the accumulation of the molecule in the lysosomes. However, interestingly, the presence of a nitro group led to their localization within the lipid droplets despite the presence of the morpholine pendant. We also showcase the probes' sensitivity to pH, the influence of added chloroquine, and the temperature response on the changes in fluorescence intensity within lysosomes. The design of the probes with strong intramolecular charge transfer and substantial Stokes shift could facilitate extensive application in various cellular lysosomal models and contribute to a better understanding of the mechanisms involved in stimuli‐responsive diseases.

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Substitution Effects on Subcellular Organelle Localization in Live‐cell Imaging

Ghorpade,

Soppina,

Kanvah

2024

ChemBioChem

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show abstract

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Real-time and in situ visualizing the details of mitochondrial fragmentation with a leakage-free fluorescent probe in living cells

Cited by 1 publication

References 39 publications

Substitution Effects on Subcellular Organelle Localization in Live‐cell Imaging

Substitution Effects on Subcellular Organelle Localization in Live‐cell Imaging

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