Real-time assessment of hepatic function is related to clinical outcome in critically ill patients after polytrauma

Dresing, K.; Armstrong, Victor W.; Leip, Casper-Lennart; Streit, Frank; Burchardi, H.; Stürmer, K M; Oellerich, Michael

doi:10.1016/j.clinbiochem.2007.06.013

Cited by 8 publications

(9 citation statements)

References 44 publications

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“…Bogner et al [36] P-coh 58 -10] is significantly higher in nonsurvivors at 72 h post injury Gouel-Chéron et al [53] P-cc 100 -10] is significantly higher in nonsurvivors when detectable on days 1 + 2 Heizmann et al [52] R-cc 195 37 (19%) 42 d N [IL-10] tends towards lower levels in nonsurvivors; not significant Maier et al [27] P-coh 251 29 (12%) In-hospital AUC ROC 0.51 N [IL-10] is not predictive for non-survival Neidhardt et al [54] P-cc 417 -10] is significantly increased in nonsurvivors on days 1 + 3 Sherry et al [14] R-cc 66 -10] is not related to non-survival Sousa et al [51] P [26] P-coh 30…”

Section: Il-6mentioning

confidence: 99%

“…] is significantly higher in nonsurvivors at 0 + 6 h Cuschieri et al [34] P-coh 152 4 (5%) In-hospital N [IL-6] is not significantly higher in nonsurvivors Dresing et al [26] P [62] P-cc 42 11 (26%) In-hospital > 400 pg/mL has a sensitivity of 100% Y [IL-6] > 400 pg/mL is significantly correlated with non-survival Yagmur et al [63] P-cc 99…”

Section: Il-6mentioning

confidence: 99%

“…6 Dresing et al [26] 2004 P-coh 30 IL-6; TNF- 13% 19% 7 Egger et al [38] 2004 P-coh 26 IL-6, -8 35% 8…”

Section: Tnf-amentioning

confidence: 99%

“…Keel et al [41] 2009 P-coh 83 IL-6 40% 12% 20 Lausevic et al [33] 2008 P-coh 65 IL-6, -10 62% 55% 51% 21 Lausevic et al [29] 2010 P-coh 65 IL-6, -10 63% 51% 22 Law et al [42] 1994 P-coh 13 IL-6, -8; TNF- 46% 23% 23 Lendemans et al [13] 2004 P-coh 16 IL-6, -10; TNF- 56% 24 Liener et al [43] 2002 P-coh 94 IL-8 0% 0% 0% 19% 25 Livingston et al [44] 1988 P-coh 20 IFN-γ 30% 15% 26 Maier et al [27] 2007 P-coh 251 IL-6, -8, -10 34% 12% 27 Meade et al [45] 1994 P-coh 25 IL-6, -8; TNF- 36% 28 Menges et al [50] 1999 P-coh 68 IL-10, -1; TNF- 25% 25% 1% 29 Mommsen et al [30] 2009 P-coh 55 IL-18 42% 13% 13% 30 Neidhardt et al [54] 1997 P-cc 417 (137) IL-10 5% 11% 22% 22% 31 Oberholzer et al [46] 2000 P-coh 1276 IL-6, IL-10 14% 40% 7% 32 Partrick et al [56] 1996 P-cc 27 (6) IL-6, -8 33% 7% 33…”

mentioning

confidence: 99%

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Predictive value of cytokines for developing complications after polytrauma

Dekker

Krijnen

Schipper

2016

WJCCM

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AIM:To investigate posttraumatic cytokine alterations and their value for predicting complications and mortality in polytraumatized patients. METHODS:Studies on the use of specific cytokines to predict the development of complications and mortality were identified in MEDLINE, EMBASE, Web of Science and the Cochrane Library. Of included studies, relevant data were extracted and study quality was scored. RESULTS:Forty-two studies published between 1988 and 2015 were identified, including 28 cohort studies and 14 "nested" case-control studies. Most studies investigated the cytokines interleukin (IL)-6, IL-8, IL-10 and tumor necrosis factor (TNF-a). IL-6 seems related to muliorgan dysfunction syndrome, multiorgan failure (MOF) and mortality; IL-8 appears altered in acute respiratory distress syndrome, MOF and mortality; IL-10 alterations seem to precede sepsis and MOF; and TNF-a seems related to MOF. CONCLUSION:Cytokine secretion patterns appear to be different for patients developing complications when compared to patients with uneventful posttraumatic course. More research is needed to strengthen the evidence for clinical relevance of these cytokines.

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Section: Il-6mentioning

confidence: 99%

Section: Il-6mentioning

confidence: 99%

“…6 Dresing et al [26] 2004 P-coh 30 IL-6; TNF- 13% 19% 7 Egger et al [38] 2004 P-coh 26 IL-6, -8 35% 8…”

Section: Tnf-amentioning

confidence: 99%

mentioning

confidence: 99%

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Predictive value of cytokines for developing complications after polytrauma

Dekker

Krijnen

Schipper

2016

WJCCM

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“…This test has been used in several studies as a quantitative index of hepatic functions [30]. It has been reported that the hepatic metabolism of Lidocaïne to Monoethylglycinexylidide (MEGX) is the basis of dynamic tests of liver function and that it is more discriminatory and recognizes early damage to the liver than con ventional individual liver function tests and it shows a good cor relation with severity of liver injuries [31][32][33].…”

Section: Liver Ischemia-reperfusionmentioning

confidence: 99%

Effect of Myrtus Communis L. Extracts on Attenuation of Liver Normothermic Ischemia-Reperfusion Injury

Ferchichi¹

2012

J Transplant Technol

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The Common Myrtle (Myrtus communis L.) is rich in antioxidants, particularly in anthocyanin. It was recognized for its anti-inflammatory and anti-thrombotic effects.The aim of our work is to evaluate the effect of Common Myrtle on a model of hepatic ischemia-reperfusion in Rat.Two morphs were chosen: white fruit Myrtle and black fruit Myrtle. Within each morph, fruit and leaf were separated and obtained extract were used to determine their effects on the hepatic model of ischemia-reperfusion.Our work was conducted in three steps (1) Induction of hepatic ischemia (90 minutes) in Wistar Rat (2) injection of the Myrtle extract during 15 minutes before reperfusion (3) and reperfusion (2 hours).To evaluate the effect of Myrtle on ischemia-reperfusion, we have monitored transaminases levels, Monoethylglycinexylidide (MEGX) concentrations (to assess the liver metabolic capacity) and Malondialdehyde (MDA) concentration.The determination of total phenol extracts of Myrtle showed a significant difference between black fruit Myrtle (11.3 µg/ml), white fruit (27 µg/ml) and black fruit Myrtle leaves (94.3 µg/ml). The latter presented the highest antioxidant activity (86.54%).With the extract from the white fruit of Myrtle, we noted a decrease of AST and ALT, respectively, 1321 U/I and 773 U/I compared with I/R group was 5757 U/I and 5404 U/I and an increase in the MEGX concentrations and decrease in MDA.The testing of extracts of Myrtle in a model of hepatic ischemia showed a difference in the protective power against damage of ischemia-reperfusion, by origin and type of fruit (black or white).

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