Real-time fMRI neurofeedback: application in patients with substance use disorder

Karch, Susanne; Keeser, Daniel; Paolini, Marco; Hümmer, Sebastian; Konrád, J; Haller, D; Kirsch, V.; Koller, G.; Kupka, M.; Blautzik, Janusch; Pogarell, Oliver

doi:10.1055/s-0035-1558015

Cited by 1 publication

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“…These three studies on eating behavior lacked control groups. Other studies found that heavy drinkers could regulate individualized brain regions associated with craving (Karch et al, 2015) or the ventral striatum (Kirsch, Gruber, Ruf, Kiefer, & Kirsch, 2016) resulting in either a marginal reduction in craving or no effect on craving, respectively. Both studies included placebo-nf conditions.…”

Section: Behavioral Effects Of Fmri-nf In Clinical Populationsmentioning

confidence: 99%

“…Reduction of cue-induced craving through realtime neurofeedback in nicotine use PMC premotor cortex Harmelech et al, (2015) Hohenfeld, C., Nellessen, N., Dogan, I., Kuhn, H., Müller, C., Papa, F., et al (2017). Cognitive improvement and brain changes after real-time functional MRI neurofeedback PHC parahippocampal cortex Hui et al, (2014); Xie et al, Karch, S., Keeser, D., Hümmer, S., Paolini, M., Kirsch, V., Karali, T., et al (2015). Modulation of craving related brain responses using real-time fMRI in patients with alcohol Kim et al, (2015) Kirsch, M., Gruber, I., Ruf, M., Kiefer, F., & Kirsch, P. (2016).…”

Section: Fcmentioning

confidence: 99%

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Neurofeedback with fMRI: A critical systematic review

et al. 2018

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Neurofeedback relying on functional magnetic resonance imaging (fMRI-nf) heralds new prospects for self-regulating brain and behavior. Here we provide the first comprehensive review of the fMRI-nf literature and the first systematic database of fMRI-nf findings. We synthesize information from 99 fMRI-nf experiments-the bulk of currently available data. The vast majority of fMRI-nf findings suggest that self-regulation of specific brain signatures seems viable; however, replication of concomitant behavioral outcomes remains sparse. To disentangle placebo influences and establish the specific effects of neurofeedback, we highlight the need for double-blind placebo-controlled studies alongside rigorous and standardized statistical analyses. Before fMRI-nf can join the clinical armamentarium, research must first confirm the sustainability, transferability, and feasibility of fMRI-nf in patients as well as in healthy individuals. Whereas modulating specific brain activity promises to mold cognition, emotion, thought, and action, reducing complex mental health issues to circumscribed brain regions may represent a tenuous goal. We can certainly change brain activity with fMRI-nf. However, it remains unclear whether such changes translate into meaningful behavioral improvements in the clinical domain.

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Section: Behavioral Effects Of Fmri-nf In Clinical Populationsmentioning

confidence: 99%