Real time in vitro studies of doxorubicin release from PHEMA nanoparticles

Chouhan, Raje; Bajpai, Anjali

doi:10.1186/1477-3155-7-5

Cited by 95 publications

(48 citation statements)

References 42 publications

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“…The amount of INN released increases with increasing percent loading. Similar results were reported previously by us and others for different drug-release system [27][28][29].…”

Section: Effect Of % Loading On Drug Releasesupporting

confidence: 81%

pH- and Thermo-Sensitive Co-polymers Based on a Hyperbranched Polymers Core as Encapsulation and Release Carriers for Guest Molecules

Jiang

Sun

Zhu

et al. 2011

Designed Monomers and Polymers

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Hyperbranched poly(3-ethyl-3-(hydroxymethyl)oxetane) (HPBO), modified by S-1-dodecyl-S -(α,α -dimethyl-α -acetic acid) trithiocarbonate (DMP) to form a RAFT macroinitiator, and then two monomers, 2-(dimethylamino)ethyl-methacrylate (DMAEMA) and acrylic acid (AA), were polymerized to obtain novel pH-and thermo-sensitive polymers with a hyperbranched polymer core. These polymers exhibited phase transitions in response to pH and temperature. They were possible to harvest a bioactive molecule, indometacin, from solution using the phase transition of these pH-and thermo-sensitive polymers. Various parameters, such as percent loading of drugs, pH, temperature and nature of the release media on the release profiles, were investigated. The resultant polymer carriers can potentially be used for the controlled release of the anti-inflammatory drug indometacin.

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“…The amount of INN released increases with increasing percent loading. Similar results were reported previously by us and others for different drug-release system [27][28][29].…”

Section: Effect Of % Loading On Drug Releasesupporting

confidence: 81%

pH- and Thermo-Sensitive Co-polymers Based on a Hyperbranched Polymers Core as Encapsulation and Release Carriers for Guest Molecules

Jiang

Sun

Zhu

et al. 2011

Designed Monomers and Polymers

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“…21 Spectrum band 5 of SPC-CHL-PE-DOX appeared stronger in comparison to that of SPC-CHL-DOX. The peak was indicative of the presence of SPC in the mixture.…”

mentioning

confidence: 99%

Doxorubicin-loaded phosphatidylethanolamine-conjugated nanoliposomes: in vitro characterization and their accumulation in liver, kidneys, and lungs in rats

Mukherjee¹

2010

IJN

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Introduction: Phosphatidylethanolamine (PE)-conjugated nanoliposomes were developed, characterized, and investigated for their accumulation in liver, kidneys, and lungs in rats. Methods: Drug-excipient interaction was studied using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), surface morphology by field emission scanning electron microscopy, elemental analysis by energy dispersive X-ray (EDX) analysis, zeta potential and size distribution using a Zetasizer and particle size analyzer, and in vitro drug release by dialysis membrane. In vivo accumulation of liposomes in tissues was also studied. Results: No chemical reaction was observed between drug and excipients. EDX study confirmed PE-conjugation in liposomes. Doxorubicin-loaded liposomes (DOX-L) and PE-conjugated doxorubicin-loaded liposomes (DOX-PEL) were of smooth surface and homogenously distributed in nanosize range (32-37 nm) with a negative surface charge. Loading efficiencies were 49.25% ± 1.05% and 52.98% ± 3.22% respectively, for DOX-L and DOX-PEL. In vitro drug release study showed 69.91% ± 1.05% and 77.07% ± 1.02% doxorubicin released, from DOX-L and DOX-PEL, respectively, in nine hours. Fluorescence microscopic study showed that liposomes were well distributed in liver, lungs, and kidneys. Conclusion: Data suggests that PE-conjugated nanoliposomes released the drug in a sustained manner and were capable of distributing them in various organs. This may be used for cell/ tissue targeting, attaching specific antibodies to PE.

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“…The negative potentials of nGO flakes decreased upon DOX incorporation because DOX passivates the oxygen-containing functional groups on the nGO flakes; furthermore, the amine groups in DOX may neutralize the negative charges on nGO surfaces (Supplementary Figure S4B). 34 cPEG incorporation further changed the zeta potential of nGO@DOX flakes to positive polarity, which may be due to the additional incorporation of amine groups from the chitosan matrix. 35 The effects of cPEG incorporation on the EE and LC of DOX were also evaluated (Supplementary Figure S4C).…”

Section: Resultsmentioning

confidence: 99%

Easy on-demand self-assembly of lateral nanodimensional hybrid graphene oxide flakes for near-infrared-induced chemothermal therapy

Thapa

Byeon

et al. 2017

NPG Asia Mater

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Near-infrared (NIR)-induced chemothermal doxorubicin (DOX) release for anticancer activity was demonstrated using DOX-incorporated fully lateral nanodimensional graphene oxide (nGO) flakes layered with chitosan-polyethylene glycol (PEG) conjugate (nGO@DOX-cPEG) from a single-pass gas-phase self-assembly. Unlike most previously reported graphene oxide-based drug carriers, the proposed processing method introduced a fully nanoscale (both in lateral dimension and thickness) configuration without multistep wet physicochemical processes that enhance the drug-loading capacity and NIR-induced heat generation resulting from the increased surface area. The accumulation of nGO@DOX-cPEG flakes in prostate cancer cells enhanced apoptotic phenomena via the combined effects of DOX release and heat generation upon NIR irradiation. The combined anticancer effects were verified through in vivo assessment with better safety profiles than free DOX. The proposed strategy warrants continuous assembly of multimodal nanocarriers for the efficient treatment of prostate cancers and may be a promising candidate for advanced drug delivery systems.

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Real time in vitro studies of doxorubicin release from PHEMA nanoparticles

Cited by 95 publications

References 42 publications

pH- and Thermo-Sensitive Co-polymers Based on a Hyperbranched Polymers Core as Encapsulation and Release Carriers for Guest Molecules

pH- and Thermo-Sensitive Co-polymers Based on a Hyperbranched Polymers Core as Encapsulation and Release Carriers for Guest Molecules

Doxorubicin-loaded phosphatidylethanolamine-conjugated nanoliposomes: in vitro characterization and their accumulation in liver, kidneys, and lungs in rats

Easy on-demand self-assembly of lateral nanodimensional hybrid graphene oxide flakes for near-infrared-induced chemothermal therapy

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