Real-time liquid crystal-based creatinine sensor using a micro-patterned flexible substrate

Lin, Chih-Teng; Hsu, Wen-Tung; Hwang, Shug-June

doi:10.1080/02678292.2021.1897889

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…Therefore, the parameters of the fluid used to prepare the LC-aqueous interface within the microchannel should be elaborately chosen. Furthermore, in order to simplify the fabrication process of the microwell structure, Lin and coworkers used soft lithography techniques to prepare PDMS-based microwell structure with SU-8 photoresist master mold [77]. After filling the microwell structure with LCs, a microfluidic channel was placed on the substrate to introduce analytes into the sensing surface using a micropump for detection.…”

Section: Fabrication Of Lc-aqueous Interface Within Microfluidic Channelsmentioning

confidence: 99%

Applications of Microfluidics in Liquid Crystal-Based Biosensors

2021

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Liquid crystals (LCs) with stimuli-responsive configuration transition and optical anisotropic properties have attracted enormous interest in the development of simple and label-free biosensors. The combination of microfluidics and the LCs offers great advantages over traditional LC-based biosensors including small sample consumption, fast analysis and low cost. Moreover, microfluidic techniques provide a promising tool to fabricate uniform and reproducible LC-based sensing platforms. In this review, we emphasize the recent development of microfluidics in the fabrication and integration of LC-based biosensors, including LC planar sensing platforms and LC droplets. Fabrication and integration of LC-based planar platforms with microfluidics for biosensing applications are first introduced. The generation and entrapment of monodisperse LC droplets with different microfluidic structures, as well as their applications in the detection of chemical and biological species, are then summarized. Finally, the challenges and future perspectives of the development of LC-based microfluidic biosensors are proposed. This review will promote the understanding of microfluidic techniques in LC-based biosensors and facilitate the development of LC-based microfluidic biosensing devices with high performance.

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Section: Fabrication Of Lc-aqueous Interface Within Microfluidic Channelsmentioning

confidence: 99%

Applications of Microfluidics in Liquid Crystal-Based Biosensors

2021

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“…Birefringent liquid crystals (LCs) are sensitive to the influence of environmental fields which change the effective refractive index of LC molecules and alter their optical properties. LC-based biosensors combine the advantages of high sensitivity, good repeatability, and good biocompatibility, so they have recently attracted considerable attention and are extensively used in physical sensing [ 11 , 12 ], chemical sensing [ 13 , 14 ], and biological sensing [ 15 , 16 ]. Cholesteric liquid crystals (CLCs) with natural periodicity can be regarded as one-dimensional photonic bandgap materials with central wavelength

and bandwidth

, where

is average refractive index, Δn is the birefringence of the LC host, and p is CLC pitch length.…”

Section: Introductionmentioning

confidence: 99%

Alcohol Selective Optical Sensor Based on Porous Cholesteric Liquid Crystal Polymer Networks

et al. 2022

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A responsive hydrogen-bonded cholesteric liquid crystal polymer (CLCP) film with controlled porosity was fabricated as an optical sensor to distinguish between methanol and ethanol in alcohol solutions. To facilitate responding the alcohols, porosity was generated by removing the nonreactive liquid crystal agent, and the hydrogen bridges of CLCP were broken. The sensitivities of CLCPs to ethanol and methanol were obtained by monitoring the wavelength shifts of the transmission spectrum at different alcohol concentrations and ratios of methanol/ethanol. Changes in the central wavelength of the CLCP network transmission spectrum allowed the methanol–ethanol ratio to be discriminated. A linear relationship between wavelength shift of CLCP networks and alcohol concentration was obtained experimentally, and the sensor characteristics were explored. The sensitivities of the CLCPs were 1.35 and 0.18 nm/% to ethanol and methanol, respectively. The sensing sensitivity of cholesteric networks to alcohol molecules increased as the methanol–ethanol ratio declined. Therefore, CLCP could act as a stimuli-responsive material to distinguish the concentrations of acetone and ethanol in mixed solutions. Furthermore, the impact of UV intensity for curing a CLC mixture on the sensing sensitivity to the different alcohol concentrations was also studied. The higher UV intensity could enhance the sensitivity to alcohol molecules and distinguishing ability between methanol and ethanol.

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“…In addition, liquid crystals (LCs) have recently drawn much attention due to their distinct optical characteristics and long range orientational order. Many researchers have exploited LCs as a signal transducer for label-free detection of biomolecules [ 25 , 26 , 27 , 28 , 29 , 30 ]. To analyse the fate of transferred protein, after μCP we utilized the LCs orientational response towards patterned protein on a DMOAP-coated slide, which yields optical readouts that are visible to the naked eye under crossed polarizers.…”

Section: Introductionmentioning

confidence: 99%

Aptamer-Based Gold Nanoparticles–PDMS Composite Stamps as a Platform for Micro-Contact Printing

2022

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In the present study, a functional template made up of in situ synthesised gold nanoparticles (AuNPs) is prepared on polydimethylsiloxane (PDMS) for patterning of target protein onto the desired solid substrates. Unlike previous studies in which bioreceptor probes are randomly attached to the PDMS stamp through electrostatic interactions, herein, we propose an AuNPs–PDMS stamp, which provides a surface for the attachment of thiol-modified biorecognition probes to link to the stamp surface through a dative bond with a single anchoring point based on thiol chemistry. By using this platform, we have developed the ability for microcontact printing (µCP) to selectively capture and transfer target protein onto solid surfaces for detection purposes. After µCP, we also investigated whether liquid crystals (LCs) could be used as a label-free approach for identifying transfer protein. Our reported approach provides promise for biosensing of various analytes.

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Real-time liquid crystal-based creatinine sensor using a micro-patterned flexible substrate

Cited by 8 publications

References 32 publications

Applications of Microfluidics in Liquid Crystal-Based Biosensors

Applications of Microfluidics in Liquid Crystal-Based Biosensors

Alcohol Selective Optical Sensor Based on Porous Cholesteric Liquid Crystal Polymer Networks

Aptamer-Based Gold Nanoparticles–PDMS Composite Stamps as a Platform for Micro-Contact Printing

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