Real-time tracking of source movement by Cherenkov emission imaging for high-dose-rate brachytherapy

Yogo, Katsunori; Tatsuno, Yuya; Shimo, Takahiro; Noguchi, Yasuhisa; Okudaira, Kuniyasu; Nozawa, Marika; Ishiyama, Hiromichi; Yasuda, Hiroshi; Oguchi, Hiroshi; Yamamoto, Seiichi

doi:10.1088/1748-0221/17/07/t07001

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…Figure 1(a) presents a schematic of the setup (Yogo et al 2020a(Yogo et al , 2021(Yogo et al , 2022. Pure water (Elix Advantage, Merck KGaA; Darmstadt, Germany) was used to eliminate contamination.…”

Section: Imaging Systemmentioning

confidence: 99%

Luminescence imaging of water irradiated by protons under FLASH radiation therapy conditions

Yogo

Kodaira²,

Kusumoto

et al. 2023

Phys. Med. Biol.

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Objective: FLASH radiation therapy with ultrahigh dose rates (UHDR) has the potential to reduce damage to normal tissue while maintaining anti-tumor efficacy. However, rapid and precise dose distribution measurements remain difficult for FLASH radiation therapy with proton beams. To solve this problem, we performed luminescence imaging of water following irradiation by a UHDR proton beam captured using a charge-coupled device camera. Approach: We used 60-MeV proton beams with dose rates of 0.03–837 Gy/s from a cyclotron. Therapeutic 139.3-MeV proton beams with dose rates of 0.45–4320 Gy/s delivered by a synchrotron-based proton therapy system were also tested. The luminescent light intensity induced by the UHDR beams was compared with that produced by conventional beams to compare the dose rate dependency of the light intensity and its profile. Main results: Luminescence images of water were clearly visualized under UHDR conditions, with significantly shorter exposure times than those with conventional beams. The light intensity was linearly proportional to the delivered dose, which is similar to that of conventional beams. No significant dose-rate dependency was observed for 0.03–837 Gy/s. The light-intensity profiles of the UHDR beams agreed with those of conventional beams. The results did not differ between accelerators (synchrotron or cyclotron) and beam energies. Significance: Luminescence imaging of water is achievable with UHDR proton beams as well as with conventional beams. The proposed method should be suitable for rapid and easy quality assurance investigations for proton FLASH therapy, because it facilitates real-time, filmless measurements of dose distributions, and is useful for rapid feedback. 

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Section: Imaging Systemmentioning

confidence: 99%

Luminescence imaging of water irradiated by protons under FLASH radiation therapy conditions

Yogo

Kodaira²,

Kusumoto

et al. 2023

Phys. Med. Biol.

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“…Other potential uses of the REA localization capability is in Radioisotope Identification (RIID) in health safety and national security [6]. Various detectors have been used in radioactive source localization [7][8][9][10][11][12][13][14]: radiosensitive films, at panel detectors (Electronic Portal Imaging Device (EPID)), gamma camera, photon counting detectors, scintillators, and others. Typically the detector is at a fixed position and radioactive sources are either static or moving.…”

Section: Introductionmentioning

confidence: 99%

Radioactive source localization employing resistive electrode array (REA) detector

Hoegele,

Zhang,

Grace Vasquez

et al. 2024

Biomed. Phys. Eng. Express

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Objective: In this feasibility study, we explore an application of a Resistive Electrode Array (REA) for localization of a radioactive point source. The inverse problem posed by multichannel REA detection is studied from mathematical perspective and involves the questions of the minimal configuration of the conductive leads that can achieve this goal. The basic configuration consists of a circularly shaped REA with four opposite electrical lead-pairs at its perimeter.Approach: A robust mathematical reconstruction method for a 3D radioactive source relative to the REA is presented. The characteristic empirical Green's function for the detector response of the REA is determined by numerically solving Laplace equations with appropriate boundary conditions. Based on this model, Monte Carlo simulations of the inverse problem with Gaussian noise are performed and the overall accuracy of the localization is investigated.Main results: The results show a 3D error distribution of localization which is uniform in the (x,y)-plane of the REA and strongly correlated in the orthogonal z-axis. The overall accuracy decreases with higher distance of the source to the detector which is intuitive due to approximate flux dependence following the inverse square law. Further, a saturation in accuracy regarding the number of electrical leads and a linear dependence of the reconstruction error on the measurement noise level are observed.Significance: A broad range of REA detector configurations and their characteristics are investigated by this study for radioactive source localization allowing diverse practical applications with detector diameters ranging from millimeters to meters.

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“…Several research studies have shown promising results and potential clinical impact for use of in-vivo source tracking for prostate [ 9 , 10 , 11 , 12 , 13 , 14 ], gyno [ 15 ] and general HDR applications [ 16 , 17 , 18 , 19 ]. Some of these studies have adopted silicon diodes, in the form of single devices, linear or 2D arrays showing positive results in source tracking [ 15 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Characterization of an Active CMOS Pad Detector for Tracking and Dosimetry in HDR Brachytherapy

Bui,

Large,

Poder

et al. 2024

Sensors

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We assessed the accuracy of a prototype radiation detector with a built in CMOS amplifier for use in dosimetry for high dose rate brachytherapy. The detectors were fabricated on two substrates of epitaxial high resistivity silicon. The radiation detection performance of prototypes has been tested by ion beam induced charge (IBIC) microscopy using a 5.5 MeV alpha particle microbeam. We also carried out the HDR Ir-192 radiation source tracking at different depths and angular dose dependence in a water equivalent phantom. The detectors show sensitivities spanning from (5.8 ± 0.021) × 10−8 to (3.6 ± 0.14) × 10−8 nC Gy−1 mCi−1 mm−2. The depth variation of the dose is within 5% with that calculated by TG-43. Higher discrepancies are recorded for 2 mm and 7 mm depths due to the scattering of secondary particles and the perturbation of the radiation field induced in the ceramic/golden package. Dwell positions and dwell time are reconstructed within ±1 mm and 20 ms, respectively. The prototype detectors provide an unprecedented sensitivity thanks to its monolithic amplification stage. Future investigation of this technology will include the optimisation of the packaging technique.

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Real-time tracking of source movement by Cherenkov emission imaging for high-dose-rate brachytherapy

Cited by 3 publications

References 33 publications

Luminescence imaging of water irradiated by protons under FLASH radiation therapy conditions

Luminescence imaging of water irradiated by protons under FLASH radiation therapy conditions

Radioactive source localization employing resistive electrode array (REA) detector

Preliminary Characterization of an Active CMOS Pad Detector for Tracking and Dosimetry in HDR Brachytherapy

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