Realgar nanoparticle-based microcapsules: preparation and in-vitro/in-vivo characterizations

Shi, Feng; Zhang, Yongtai; Omari‐Siaw, Emmanuel

doi:10.1111/jphp.12314

Cited by 14 publications

(7 citation statements)

References 20 publications

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“…The optimal CuA‐SEN was morphologically homogenous and spherical or elliptical (Figure d) in shape with the absence of aggregation when observed under TEM. The average DS, PDI and ZP produced were 48.83 ± 1.06 nm, 0.232 ± 0.14 and −29.92 ± 1.66 mV (Table ), respectively.…”

Section: Resultsmentioning

confidence: 98%

“…The disappearance of characteristic peaks of cuminaldehyde might be ascribed to the overlapping of drug peaks with that of the excipients. [61] Physical characteristics of optimal CuA-SEN The optimal CuA-SEN was morphologically homogenous and spherical or elliptical (Figure 3d) in shape [36,73] with the absence of aggregation when observed under TEM. The average DS, PDI and ZP produced were 48.83 AE 1.06 nm, 0.232 AE 0.14 and À29.92 AE 1.66 mV (Table 2), respectively.…”

Section: Characterisation Of Cua-senmentioning

confidence: 99%

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Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice

Adu‐Frimpong

Wei

Firempong

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Cuminaldehyde self‐emulsified nanoemulsion (CuA‐SEN) was prepared and optimised to improve its oral bioavailability and antihepatotoxicity. Methods Cuminaldehyde self‐emulsified nanoemulsion was developed through the self‐nanoemulsification method using Box–Behnken Design (BBD) tool while appropriate physicochemical indices were evaluated. The optimised CuA‐SEN was characterised via droplet size (DS), morphology, polydispersity index (PDI), zeta potential (ZP), entrapment efficiency, in‐vitro release, and pharmacokinetic studies while its antihepatotoxicity was evaluated. Key findings Cuminaldehyde self‐emulsified nanoemulsion with acceptable characteristics (mean DS‐48.83 ± 1.06 nm; PDI‐0.232 ± 0.140; ZP‐29.92 ± 1.66 mV; EE‐91.51 ± 0.44%; and drug‐loading capacity (DL)‐9.77 ± 0.75%) was formulated. In‐vitro drug release of CuA‐SEN significantly increased with an oral relative bioavailability of 171.02%. Oral administration of CuA‐SEN to CCl4‐induced hepatotoxicity mice markedly increased the levels of superoxide dismutase, glutathione and catalase in serum. Also, CuA‐SEN reduced the levels of tumour necrosis factor‐alpha and interleukin‐6 in both serum and liver tissues while aspartate aminotransferase, alanine aminotransferase and malonaldehyde levels were significantly decreased. Conclusions These findings showed that the improved bioavailability of cuminaldehyde via SEN provided an effective approach for enhancing antioxidation, anti‐inflammation and antihepatotoxicity of the drug.

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Section: Resultsmentioning

confidence: 98%

Section: Characterisation Of Cua-senmentioning

confidence: 99%

Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice

Adu‐Frimpong

Wei

Firempong

et al. 2019

Journal of Pharmacy and Pharmacology

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“…[77]. Additional, RBS has the same effect for other cancer cells, such as H22 cancer cells in mice [1]. …”

Section: The Antitumor Effect and Application Of Realgar Bioleaching mentioning

confidence: 99%

“…Realgar, a traditional Chinese medicine, has been applied for more than 1800 years [1] to treat skin diseases by ancient Chinese doctors. Recent studies have indicated that realgar has an obvious anticancer effect in the clinic, especially on hematological cancer.…”

Section: Introductionmentioning

confidence: 99%

Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent

Chen

Yan

et al. 2017

Biol Res

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Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetra-sulfide (As4S4). Currently, realgar has been confirmed the antitumor activities, both in vitro and in vivo, of realgar extracted using Acidithiobacillus ferrooxidans (A. ferrooxidans). Bioleaching, a new technology to greatly improve the use rate of arsenic extraction from realgar using bacteria, is a novel methodology that addressed a limitation of the traditional method for realgar preparation. The present systematic review reports on the research progress in realgar bioleaching and its antitumor mechanism as an anticancer agent. A total of 93 research articles that report on the biological activity of extracts from realgar using bacteria and its preparation were presented in this review. The realgar bioleaching solution (RBS) works by inducing apoptosis when it is used to treat tumor cells in vitro and in vivo. When it is used to treat animal model organisms in vivo, such as mice and Caenorhabditis elegans, tumor tissues grew more slowly, with mass necrosis. Meanwhile, the agent also showed obvious inhibition of tumor cell growth. Bioleaching technology greatly improves the utilization of realgar and is a novel methodology to improve the traditional method.

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“…As described in our previous study, the ball milling equipment (PM 100, Retsch, German) was used to formulate the realgar powder into the realgar nanoparticles (RN, mean size 85.4 AE 3.5 nm), which were further converted into the RN-based microcapsules (RNM) to improve the stability. The RNM exhibited a considerably higher release of As 2 S 2 , bioavailability, and antitumor efficacy than the crude realgar did (Shi et al, 2015). The FMO unit was processed using a high-pressure homogenization method.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a micro/nanotechnology based multi-unit drug delivery system for a Chinese medicine Niuhuang Xingxiao Wan and assessment of its antitumor efficacy

Feng

Zhang

Yang

2015

International Journal of Pharmaceutics

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Realgar nanoparticle-based microcapsules: preparation and in-vitro/in-vivo characterizations

Abstract: The developed RNM demonstrated a greater potential as a delivery system for realgar.

Cited by 14 publications

References 20 publications

Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice

Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice

Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent

Preparation of a micro/nanotechnology based multi-unit drug delivery system for a Chinese medicine Niuhuang Xingxiao Wan and assessment of its antitumor efficacy

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